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Registry of Toxic Effects of Chemical Substances (RTECS)

Spinosad

RTECS #

WG9110000

CAS #

168316-95-8

Updated

October 2010

Molecular Weight

1477.96

Molecular Formula

C41H65NO10·C42H67NO10

Synonyms

Spinosad technical

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 2025 mg/kg (90D male/90D prior to copulation)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Uterus, cervix, vagina
FEREAC 67,60923,2002
unreported route/mammal (species unspecified) 2.68 mg/kg (multigenerations)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
FEREAC 66,1594,2001
unreported route/mammal (species unspecified) 100 mg/kg (multigenerations)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
FEREAC 64,28364,1999

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >5.18 mg/m3HBPTO* 1,140,2001
oral/duck lethal dose (50 percent kill): >2000 mg/kgHBPTO* 1,140,2001
oral/mouse lethal dose (50 percent kill): >5000 mg/kgFEREAC 70,41730,2005
oral/quail lethal dose (50 percent kill): >2000 mg/kgHBPTO* 1,140,2001
oral/rat lethal dose (50 percent kill): 3738 mg/kgFEREAC 69,35024,2004
oral/rat lethal dose (50 percent kill): 3.738 mg/kgReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
FEREAC 70,41730,2005
skin/rabbit lethal dose (50 percent kill): >5000 mg/kgFEREAC 70,41730,2005
skin/rat lethal dose (50 percent kill): 2800 mg/kgFEREAC 64,51453,1999

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 875.7 mg/kg/90D- intermittentLiver: Other changes

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 67,60923,2002
oral/mouse lowest published toxic dose: 2025 mg/kg/90D- intermittentCardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
FEREAC 67,60923,2002
oral/mouse lowest published toxic dose: 1876.9 mg/kg/13W- intermittentBlood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOSCF2 65,276,2002
oral/mouse lowest published toxic dose: 7260 mg/kg/44D- intermittentLiver: Multiple effects

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOSCF2 65,276,2002
oral/rat lowest published toxic dose: 3084.9 mg/kg/13W- intermittentLiver: Other changes

Gastrointestinal: Changes in structure or function of exocrine pancreas

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TOSCF2 65,288,2002
oral/rat lowest published toxic dose: 9492 mg/kg/5W- intermittentLiver: Multiple effects

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOSCF2 65,288,2002
oral/rat lowest published toxic dose: 6165 mg/kg/90D- intermittentEndocrine: Adrenal cortex hypoplasiaFEREAC 67,60923,2002

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTOXIA6 49,413,2007
TOXICOLOGY REVIEWFEREAC 71,11519,2006
TOXICOLOGY REVIEWFEREAC 72,13168,2007
TOXICOLOGY REVIEWFEREAC 72,68534,2007
TOXICOLOGY REVIEWFEREAC 72,49651,2007
TOXICOLOGY REVIEWJTPAE7 21,9,2008
TOXICOLOGY REVIEWFEREAC 74,48402,2009

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESActive registrationRBREV* -,393,1998
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