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Registry of Toxic Effects of Chemical Substances (RTECS)

Sodium sulfite (2:1)

RTECS #

WE2150000

CAS #

7757-83-7; 10579-83-6; 68135-69-3

Updated

July 2011

Molecular Weight

126.04

Molecular Formula

O3S·2Na

Synonyms

Anhydrous sodium sulfite
Disodium sulfite
Exsiccated sodium sulfite
Natriumsulfit (German)
Sodium sulfite
Sodium sulfite anhydrous
Sodium sulphite
Sulftech
Sulfurous acid, disodium salt
Sulfurous acid, sodium salt (1:2)
S-WAT

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisother cell types/mouse25 mg/LENVRAL 9,84,1975
Cytogenetic Analysisother cell types/domestic animal250 mg/LENVRAL 9,84,1975
Cytogenetic Analysisother cell types/cattle250 mg/LENVRAL 9,84,1975
mutation in microorganisms/Other microorganisms600 ppm (-enzymatic activation step)POASAD 34,114,1953
other mutation test systemslymphocyte/human100 µmol/LCHRTBC 4,211,1973
sperm morphologyother cell types/mouse25 mg/LENVRAL 9,84,1975
sperm morphologyother cell types/domestic animal250 mg/LENVRAL 9,84,1975
sperm morphologyother cell types/cattle250 mg/LENVRAL 9,84,1975

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 11 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
intraperitoneal/mouse lethal dose (50 percent kill): 950 mg/kgENTOX* ,64,2005
intravenous/cat lowest published lethal dose: 400 mg/kgAHYGAJ 57,87,1906
intravenous/guinea pig lowest published lethal dose: 200 mg/kgHBAMAK 4,1289,1935
intravenous/mouse lethal dose (50 percent kill): 175 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes
JPETAB 101,101,1951
oral/mouse lethal dose (50 percent kill): 820 mg/kgTRENAF 27,159,1976
oral/rabbit lowest published lethal dose: 2825 mg/kgAHYGAJ 57,87,1906
oral/rat lethal dose (50 percent kill): 3560 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Skin and Appendages: Other: Hair
IJTOFN 19,349,2000
subcutaneous/cat lowest published lethal dose: 1300 mg/kgHBAMAK 4,1289,1935
subcutaneous/Dog lowest published lethal dose: 1300 mg/kgHBAMAK 4,1289,1935
subcutaneous/guinea pig lowest published lethal dose: 600 mg/kgHBAMAK 4,1289,1935
subcutaneous/rabbit lowest published lethal dose: 600 mg/kgAHYGAJ 57,87,1906

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 54,131,1992
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 54,131,1992
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 54,131,1992
TOXICOLOGY REVIEWIJTOFN 22,63,2003
TOXICOLOGY REVIEWENTOX* -,64,2005
TOXICOLOGY REVIEWENTOX* -,113,2005

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,321,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X5886; Number of Industries 177; Total Number of Facilities 31580; Number of Occupations 116; Total Number of Employees Exposed 309663; Total Number of Female Employees Exposed 122038

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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