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Registry of Toxic Effects of Chemical Substances (RTECS)

Sodium sulfide

RTECS #

WE1900000

CAS #

16721-80-5; 1310-76-5

Updated

May 2008

Molecular Weight

56.06

Molecular Formula

HNaS

Synonyms

Sodium bisulfide
Sodium hydrogen sulfide
Sodium hydrosulfide
Sodium mercaptan
Sodium mercaptide
Sodium sulfhydrate

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium2 µmol/plate (+enzymatic activation step)MUREAV 90,91,1981
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster50 mmol/LMUREAV 90,91,1981
sex chromosome loss and nondisjunctionmultiple/Drosophila melanogaster2000 ppmACBIEF 14(52),48,1985

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 18 mg/kgBehavioral: ComaDCTODJ 1,327,1978
intraperitoneal/rat lethal dose (50 percent kill): 14600 µg/kgBCPCA6 38,973,1989
oral/rat lowest published toxic dose: 1.85 µg/kgGastrointestinal: Other changesTXCYAC 241,11,2007
subcutaneous/mouse lethal dose (50 percent kill): 200 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Lung, Thorax, or Respiration: Respiratory stimulation

Lung, Thorax, or Respiration: Other changes
JJPAAZ 3,99,1954

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 35 mg/kg/5D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)
NRTXDN 11,93,1990
intraperitoneal/rat lowest published toxic dose: 67500 µg/kg/3D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)
NRTXDN 11,93,1990

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83515; Number of Industries 18; Total Number of Facilities 577; Number of Occupations 34; Total Number of Employees Exposed 12517; Total Number of Female Employees Exposed 4278
National Occupational Hazard Survey 1974Hazard Code 83515; Number of Industries 5; Total Number of Facilities 94; Number of Occupations 10; Total Number of Employees Exposed 359

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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