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Registry of Toxic Effects of Chemical Substances (RTECS)

Sodium sulfate (2:1)

RTECS #

WE1650000

CAS #

7757-82-6

Updated

July 2011

Molecular Weight

142.04

Molecular Formula

O4S·2Na

Synonyms

Bisodium sulfate
Dibasic sodium sulfate
Disodium monosulfate
Disodium sulfate
Kemol
Natriumsulfat (German)
Salt cake
Sodium sulfate anhydrous
Sodium sulphate
Sulfuric acid, disodium salt
Thenardite

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 14 gm/kg (8-12D pregnant)Reproductive: Effects on newborn: Other neonatal measures or effectsTCMUD8 6,361,1986
parenteral/mouse 60 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JPMSAE 62,1626,1973

Tumorigenic Data and References

Route/OrganismDoseEffectReference
subcutaneous/mouse lowest published toxic dose: 806 mg/kg/26W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
IVIVE4 1,39,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 73 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
intravenous/mouse lowest published lethal dose: 1220 mg/kgCLDND*
intravenous/rabbit lethal dose (50 percent kill): 1220 mg/kgNIIRDN -,1257,1990
oral/mouse lethal dose (50 percent kill): 5989 mg/kgENTOX* ,110,2005

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWENTOX* -,110,2005
TOXICOLOGY REVIEWNBREV* 5,1,1981

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,320,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81663; Number of Industries 311; Total Number of Facilities 68367; Number of Occupations 202; Total Number of Employees Exposed 1332131; Total Number of Female Employees Exposed 543877
National Occupational Hazard Survey 1974Hazard Code 81663; Number of Industries 311; Total Number of Facilities 94825; Number of Occupations 160; Total Number of Employees Exposed 866411

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8786
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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