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Registry of Toxic Effects of Chemical Substances (RTECS)

Sodium(I) nitrate (1:1)

RTECS #

WC5600000

CAS #

7631-99-4

Updated

October 2012

Molecular Weight

85.00

Molecular Formula

NO3·Na

Synonyms

Chile saltpeter
Cubic niter
Nitrate de sodium (French)
Nitratine
Nitric acid, sodium salt
Soda niter
Sodium nitrate
Sodium saltpeter

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/rat78500 µg/kgMUREAV 155,121,1985
Cytogenetic Analysisoral/mouse7067 mg/kgMUREAV 155,121,1985
Cytogenetic Analysisfibroblast/hamster7200 mg/L/48HMUREAV 48,337,1977
Cytogenetic Analysislung/hamster5700 mg/LGMCRDC 27,95,1981
host-mediated assayembryo/hamster125 mg/kgMUREAV 66,149,1979
micronucleus testoral/hamster250 mg/kgMUREAV 66,149,1979
micronucleus testoral/mouse78500 µg/kgMUREAV 155,121,1985
morphological transformoral/rat13 gm/kg/6WCRNGDP 9,387,1988
morphological transformoral/hamster250 mg/kgMUREAV 66,149,1979
mutation in microorganisms/Other microorganisms1000 ppm (-enzymatic activation step)POASAD 34,114,1953
phage inhibition capacity/Escherichia coli133 µg/wellMUREAV 260,349,1991
sperm morphologyoral/mouse16800 mg/kg/2WMUREAV 204,689,1988
Unscheduled DNA SynthesisHeLa cell/human6 mmol/LAEMBAP 177,269,1984

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 16800 mg/kg (14D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)MUREAV 204,689,1988

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 100 gm/kg/2Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
FCTOD7 22,715,1984
oral/rat toxic dose: 1825 gm/kg/2Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Tumorigenic effects: Testicular tumors
FCTOD7 20,25,1982
oral/rat toxic dose: 913 gm/kg/2Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Tumorigenic effects: Testicular tumors
FCTOD7 20,25,1982

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 125 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
intraperitoneal/rat Lethal dose: >181 mg/kgTXAPA9 5,750,1963
intravenous/mouse lethal dose (50 percent kill): 175 mg/kgATXKA8 21,89,1965
oral/child lowest published lethal dose: 22500 µg/kgBlood: Methemoglobinemia- CarboxhemoglobinemiaJTCTDW 32,173,1994
oral/mouse lethal dose (50 percent kill): 3500 mg/kgVCVN5* -,49,1993
oral/pig lowest published toxic dose: 0.5 gm/kgBehavioral: Change in psychophysiological tests

Behavioral: Food intake (animal)

Blood: Methemoglobinemia- Carboxhemoglobinemia
GISAAA -,30,1993
oral/rabbit lethal dose (50 percent kill): 2680 mg/kgSOVEA7 27,246,1974
oral/rat lethal dose (50 percent kill): 1267 mg/kgGISAAA 46(12),66,1981
oral/rat lowest published toxic dose: 1600 mg/kgBlood: Methemoglobinemia- CarboxhemoglobinemiaTOVEFN (5),22,1996
oral/woman lowest published toxic dose: 14 mg/kgCardiac: Pulse rate increased without fall in BP

Lung, Thorax, or Respiration: Cyanosis

Blood: Methemoglobinemia- Carboxhemoglobinemia
JTCTDW 32,173,1994

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/pig lowest published toxic dose: 3.5 gm/kg/1W- continuousBlood: Methemoglobinemia- CarboxhemoglobinemiaGISAAA -,30,1993
oral/pig lowest published toxic dose: 28 gm/kg/8W- continuousGastrointestinal: GastritisGISAAA -,30,1993
oral/rat lowest published toxic dose: 1224 mg/kg/30D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
VCVN5* -,50,1989
oral/rat lowest published toxic dose: 3000 mg/kg/60D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FCTOD7 48,572,2010
oral/rat lowest published toxic dose: 6000 mg/kg/60D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Changes in testicular weight
FCTOD7 48,572,2010
oral/rat lowest published toxic dose: 118 gm/kg/39W- continuousLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOLED5 17,125,1983
oral/rat lowest published toxic dose: 386 gm/kg/61W- continuousLung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 6,199,1980

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTXAPA9 243,180,2010
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,318,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 69220; Number of Industries 249; Total Number of Facilities 40765; Number of Occupations 152; Total Number of Employees Exposed 557740; Total Number of Female Employees Exposed 110040
National Occupational Hazard Survey 1974Hazard Code 69220; Number of Industries 164; Total Number of Facilities 17916; Number of Occupations 119; Total Number of Employees Exposed 165980

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: SHE-clonal assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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