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Registry of Toxic Effects of Chemical Substances (RTECS)

Sodium monohydrogen phosphate (2:1:1)

RTECS #

WC4500000

CAS #

7558-79-4

Updated

July 2010

Molecular Weight

141.96

Molecular Formula

HO4P·2Na

Synonyms

Dibasic sodium phosphate
Disodium hydrogen phosphate
Disodium monohydrogen phosphate
Disodium orthophosphate
Disodium phosphate
Disodium phosphoric acid
Exsiccated sodium phosphate
Natriumphosphat (German)
Phosphoric acid, disodium salt
Soda phosphate
Sodium hydrogen phosphate
Sodium phosphate
Sodium phosphate, dibasic

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild28ZPAK -,16,1972
skin /rabbit 500 mg/24H mild28ZPAK -,16,1972

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intramuscular/rat lowest published lethal dose: 1 gm/kgBIZEA2 163,226,1925
intraperitoneal/rat lowest published lethal dose: 1 gm/kgBIZEA2 163,226,1925
intravenous/rabbit lowest published lethal dose: 1075 mg/kgBehavioral: TetanyHXPHAU 10,361,1950
intravenous/rat lowest published toxic dose: 8 mL/kgKidney, Ureter, and Bladder: Other changesJTPAE7 21,229,2008
oral/rat lethal dose (50 percent kill): 17000 mg/kgUSXXAM #6365129
subcutaneous/rat lowest published lethal dose: 1 gm/kgBIZEA2 163,226,1925

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intravenous/rat lowest published toxic dose: 3976 mg/kg/14D- intermittentKidney, Ureter, and Bladder: Changes primarily in glomeruli

Kidney, Ureter, and Bladder: Proteinuria
TOPADD 32,408,2004
intravenous/rat lowest published toxic dose: 1988 mg/kg/7D- intermittentKidney, Ureter, and Bladder: ProteinuriaTOPADD 32,408,2004
intravenous/rat lowest published toxic dose: 24 mL/kg/3D- intermittentKidney, Ureter, and Bladder: Changes primarily in glomeruli

Kidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Other changes
JTPAE7 21,229,2008
intravenous/rat lowest published toxic dose: 64 mL/kg/8D- intermittentKidney, Ureter, and Bladder: Changes primarily in glomeruli

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Changes in: Ca
JTPAE7 21,229,2008

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,318,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83514; Number of Industries 166; Total Number of Facilities 21015; Number of Occupations 135; Total Number of Employees Exposed 1230592; Total Number of Female Employees Exposed 912048
National Occupational Hazard Survey 1974Hazard Code 83514; Number of Industries 85; Total Number of Facilities 6564; Number of Occupations 60; Total Number of Employees Exposed 57176

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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