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Sodium iodide

RTECS #: WB6475000

CAS #: 7681-82-5


UPDATE: February 2006 MW: 149.89 MF: INa


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Ioduril
  2. Jodid sodny (Czech)
  3. Natriumjodid (German)
  1. Sodium iodine
  2. Sodium monoiodide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg/24 hour moderate 28ZPAK -,21,1972
skin
rabbit
500 mg/24 hour moderate 28ZPAK -,21,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
woman
lowest published toxic dose: 9,240 mg/kg (1-43 week pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Other postnatal measures or effects
ADCHAK 38,526,1963


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published lethal concentration: 50,000 mg/m3/2 hour N/R VCVN5* -,404,1989
intraperitoneal
mouse
lethal dose (50 percent kill): 430 mg/kg N/R PSEBAA 115,551,1964
intraperitoneal
rat
lowest published toxic dose: 600 g( intermittent)/kg Endocrine: Evidence of thyroid hypofunction FATOAO 45,96,1982
intravenous
dog
lowest published lethal dose: 760 mg/kg N/R HBAMAK 4,1289,1935
intravenous
rat
lethal dose (50 percent kill): 1,060 mg/kg N/R AEPPAE 222,584,1954
oral
man
lowest published toxic dose: 100 L/kg/14 day- intermittent Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
CLECAP 28,283,1988
oral
mouse
lethal dose (50 percent kill): 1,000 mg/kg N/R VCVN5* -,404,1989
oral
rat
lethal dose (50 percent kill): 4,340 mg/kg N/R 28ZPAK -,21,1972
oral
rat
lowest published lethal dose: 1,600 mg/kg N/R VCVN5* -,404,1989
oral
rabbit
lowest published lethal dose: 2,362 mg/kg N/R JPETAB 30,407,1927


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 64,267 g/kg/14 week- continuous Endocrine: Changes in thyroid weight

Blood: Other changes
JTEHD6 32,89,1991
oral
rat
lowest published toxic dose: 84 gm/kg/28 day- continuous Skin and Appendages: Other glands

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
PSEBAA 114,341,1963
oral
rat
lowest published toxic dose: 7,497 mg/kg/90 day- continuous Endocrine: Changes in thyroid weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
ACEDAB 69,321,1972
oral
rat
lowest published toxic dose: 6,715.5 mg/kg/121 day- continuous Endocrine: Changes in thyroid weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
ACEDAB 69,321,1972
oral
rat
lowest published toxic dose: 840 mg/kg/12 week- continuous Endocrine: Other changes EJEND* 137,89,1997
oral
rat
lowest published toxic dose: 140 mg/kg/2 week- intermittent Liver: Changes in liver weight TOXID9 72,284,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 69120;
Number of Industries 7;
Total Number of Facilities 529;
Number of Occupations 9;
Total Number of Employees Exposed 6,918
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 69120;
Number of Industries 14;
Total Number of Facilities 1,773;
Number of Occupations 27;
Total Number of Employees Exposed 63,333;
Total Number of Female Employees Exposed 49,362


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948-
ADCHAK Archives of Disease in Childhood. (British Medical Journal, POB 560B, Kennebunkport, ME 04046) V.1- 1926-
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
CLECAP Clinical Endocrinology (Oxford). (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1972-
EJEND* European journal of endocrinology (European journal of endocrinology, Bristol, UK : BioScientifica Ltd.) V.130- 1994-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used as an expectorant, iodine supplement, actinobacillosis and actinomycosis agent

RTECS Compound Description:
   Reproductive Effector
   Human Data
   Primary Irritant

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