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Sodium bicarbonate (1:1)

RTECS #: VZ0950000

CAS #: 144-55-8


UPDATE: May 2008 MW: 84.01 MF: CHO3Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Baking soda
  2. Bicarbonate of soda
  3. Carbonic acid monosodium salt
  4. Col - evac
  5. Jusonin
  1. Monosodium carbonate
  2. NEUT
  3. Soda mint
  4. Sodium acid carbonate
  5. Sodium hydrogen carbonate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg/30S mild TXCYAC 23,281,1982
skin
human
30 mg/3 day- intermittent mild 85DKA8 -,127,1977


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
unscheduled DNA synthesis oral
rat
50,400 mg/kg/4 week- continuous CRNGDP 9,1203,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 40 mg/kg (7 day pregnant) Reproductive: Other developmental abnormalities POASAD 56,10,1976


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration : >900 mg/m3 N/R GTPZAB 33(5),30,1989
oral
infant
lowest published toxic dose: 1,260 mg/kg Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Urine volume increased

Nutritional and Gross Metabolic: Changes in: Na
AJDCAI 135,965,1981
oral
man
lowest published toxic dose: 20 mg/kg/5 day- intermittent Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Changes in: K

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
AJEMEN 12,57,1994
oral
mouse
lethal dose (50 percent kill): 3,360 mg/kg N/R GTPZAB 33(5),30,1989
oral
rat
lethal dose (50 percent kill): 4,220 mg/kg N/R TXAPA9 6,726,1964


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 77,200 g/kg/17 week Cardiac: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: Na
GTPZAB 33(5),30,1989
oral
domestic bird
lowest published toxic dose: 17,500 mg/kg/35 day- continuous Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Changes in: Cl

Nutritional and Gross Metabolic: Changes in: K
DCTODJ 28,245,2005
oral
domestic bird
lowest published toxic dose: 65,625 mg/kg/35 day- continuous Kidney, Ureter, and Bladder: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
DCTODJ 28,245,2005
oral
domestic bird
lowest published toxic dose: 175,000 mg/kg/35 day- continuous Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Behavioral: Fluid intake
DCTODJ 28,245,2005
oral
domestic bird
lowest published toxic dose: 175,000 mg/kg/35 day- continuous Cardiac: Cardiomyopathy including infarction

Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes
DCTODJ 28,245,2005
oral
domestic bird
lowest published toxic dose: 175,000 mg/kg/35 day- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
DCTODJ 28,245,2005
oral
domestic bird
lowest published toxic dose: 175,000 mg/kg/35 day- continuous Musculoskeletal: Joints

Musculoskeletal: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
DCTODJ 28,245,2005
oral
domestic bird
lowest published toxic dose: 350,000 mg/kg/35 day- continuous Kidney, Ureter, and Bladder: Structural or functional change in ureter

Kidney, Ureter, and Bladder: Changes in kidney weight

Blood: Changes in spleen
DCTODJ 28,245,2005
oral
domestic bird
lowest published toxic dose: 350,000 mg/kg/35 day- continuous Gastrointestinal: Other changes DCTODJ 28,245,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
JRPMAP 12,27,1974
TOXICOLOGY REVIEW
BPCEM* 17,237,2003
TOXICOLOGY REVIEW
ENTOX* -,60,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80069;
Number of Industries 158;
Total Number of Facilities 27,050;
Number of Occupations 111;
Total Number of Employees Exposed 236,575
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9090;
Number of Industries 1;
Total Number of Facilities 38;
Number of Occupations 4;
Total Number of Employees Exposed 1,325;
Total Number of Female Employees Exposed 1,035
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80069;
Number of Industries 206;
Total Number of Facilities 30,686;
Number of Occupations 169;
Total Number of Employees Exposed 881,879;
Total Number of Female Employees Exposed 416,265


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960-
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
BPCEM* Best Practice & Research Clinical Endocrinology and Metabolism (Elsevier Ltd.) V.13- 1999-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969-
POASAD Proceedings of the Oklahoma Academy of Science. (Oklahoma Academy of Science, c/o Executive Secretary-Treasurer, Southwestern Oklahoma State Univ., Weatherford, OK 73096) V.1- 1910/1920-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

FDA-over the counter and proprietary drug

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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