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Registry of Toxic Effects of Chemical Substances (RTECS)

Sodium chlorite

RTECS #

VZ4800000

CAS #

7758-19-2

Updated

October 2012

Molecular Weight

91.45

Molecular Formula

ClHO2·Na

Synonyms

Alcide LD
Chlorous acid, sodium salt (8CI,9CI)
Neo Silox D
Textile
Textone

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisfibroblast/hamster20 mg/LFCTOD7 22,623,1984
DNA inhibitionoral/rat84 mg/kg/12W-continuousJEPOEC 6(1),105,1985
micronucleus testintraperitoneal/mouse15 mg/kgFCTOD7 26,487,1988
mutation in microorganisms/Salmonella typhimurium300 µg/plate (-enzymatic activation step)FCTOD7 22,623,1984
sperm morphologyoral/rat660 mg/kg/66D-continuousENVRAL 42,238,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 160 mg/kg (8-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)EVHPAZ 46,25,1982
intraperitoneal/rat 80 mg/kg (8-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)EVHPAZ 46,25,1982
oral/mouse 22 gm/kg (1-21D preg/28D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)BECTA6 25,689,1980
oral/rat 2.1 gm/kg (10W male/10W pre-4W after birth)Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)

Reproductive: Effects on newborn: Physical
JJATDK 20,291,2000
oral/rat 8 gm/kg (10W male/10W pre-25D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)JJATDK 20,291,2000
oral/rat 9 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)JJATDK 20,291,2000
oral/rat 69 mg/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical
JJATDK 20,291,2000
oral/rat 800 mg/kg (8-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)EVHPAZ 46,25,1982
oral/rat 16 gm/kg (8-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)EVHPAZ 46,25,1982
oral/rat 660 mg/kg (66D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)ENVRAL 42,238,1987
oral/rat 1130 mg/kg (8W male/2W pre-3W after birth)Reproductive: Effects on newborn: Biochemical and metabolicTJADAB 35,43A,1987

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 29750 mg/kg/85W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
EVHPAZ 69,221,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 230 mg/m3/4HNTIS** OTS0534543
oral/guinea pig lethal dose (50 percent kill): 300 mg/kgGISAAA 45(4),6,1980
oral/guinea pig lethal dose (50 percent kill): 300 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVN1* -,36,1998
oral/man lowest published toxic dose: 143 mg/kgLung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
REFAE8 15,645,1993
oral/mouse lethal dose (50 percent kill): 350 mg/kgVCVN1* -,36,1998
oral/rat lethal dose (50 percent kill): 350 mg/kgVCVN1* -,36,1998
oral/rat lethal dose (50 percent kill): 165 mg/kgLiver: Jaundice, other or unclassified

Kidney, Ureter, and Bladder: Interstitial nephritis

Biochemical: Metabolism (intermediary): Other
YKYUA6 31,959,1980
oral/rat lowest published toxic dose: 200 mg/kgReproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glandsREPTED 6,491,1992
unreported route/mouse lowest published lethal dose: 300 mg/kgVCVN1* -,39,1998
unreported route/rat lowest published lethal dose: 300 mg/kgBehavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Cyanosis
VCVN1* -,39,1998

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 168 mg/kg/28D- continuousImmunological Including Allergic: Uncharacterized (multiple organ involvement)TOXID9 54,157,2000
oral/mouse lowest published toxic dose: 22 mg/kg/22D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTPTR* IMM-98005
oral/mouse lowest published toxic dose: 28 mg/kg/28D- intermittentEndocrine: Changes in spleen weightNTPTR* IMM-98005
oral/mouse lowest published toxic dose: 0.56 mg/kg/28D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Immunological Including Allergic: Decrease in cellular immune response
NTPTR* IMM-98005
oral/mouse lowest published toxic dose: 84 mg/kg/28D- intermittentBlood: Changes in cell count (unspecified)NTPTR* IMM-98005
oral/mouse lowest published toxic dose: 168 mg/kg/28D- intermittentImmunological Including Allergic: Increase in cellular immune responseNTPTR* IMM-98005
oral/rat lowest published toxic dose: 2730 mg/kg/10W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainJJATDK 20,291,2000
oral/rat lowest published toxic dose: 280 mg/kg/10W- continuousBehavioral: Fluid intakeJJATDK 20,291,2000
oral/rat lowest published toxic dose: 168 mg/kg/24W- intermittentCardiac: Cardiomyopathy including infarction

Liver: Changes in liver weight

Immunological Including Allergic: Decrease in cellular immune response
VCVN1* -,40,1988
oral/rat lowest published toxic dose: 365 mg/kg/1Y- continuousBlood: Pigmented or nucleated red blood cells

Blood: Changes in other cell count (unspecified)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JEPOEC 6(1),105,1985
oral/rat lowest published toxic dose: 182 gm/kg/26W- intermittentLiver: Liver function tests impaired

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
GISAAA 45(4),6,1980

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 52,145,1991
International Agency for Research on Cancer (IARC)Cancer Review:Human No Available DataIMEMDT 52,145,1991
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 52,145,1991
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,301,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81982; Number of Industries 20; Total Number of Facilities 532; Number of Occupations 27; Total Number of Employees Exposed 18585; Total Number of Female Employees Exposed 4817
National Occupational Hazard Survey 1974Hazard Code 81982; Number of Industries 8; Total Number of Facilities 129; Number of Occupations 13; Total Number of Employees Exposed 1968

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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