Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Sodium carbonate (2:1)

RTECS #

VZ4050000

CAS #

497-19-8; 1332-57-6

Updated

July 2011

Molecular Weight

105.99

Molecular Formula

CO3·2Na

Synonyms

Bisodium carbonate
Calcined soda
Carbonic acid, disodium salt
Crystol carbonate
Disodium carbonate
Snowlite 1
Soda ash
Sodium carbonate
Solvay soda

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg/24H moderate28ZPAK -,8,1972
eye /rabbit 100 mg/30S rinse mildTXCYAC 23,281,1982
eye /rabbit 50 mg severeGTPZAB 20(11),55,1976
skin /rabbit 500 mg/24H mild28ZPAK -,7,1972

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intrauterine/mouse 84800 ng/kg (4D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)JRPFA4 63,365,1981

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
eye/rabbit lowest published toxic dose: 25 mg/kgBehavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Cyanosis
VCVN1* -,38,1998
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 16 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
inhalation/guinea pig lethal concentration (50 percent kill): 800 mg/m3/2HLung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Other changes
ENVRAL 31,138,1983
inhalation/human lowest published toxic concentration: 40 mg/m3/1MEye: Lacrimation

Eye: Conjunctiva irritation
VCVN1* -,38,1998
inhalation/mammal (species unspecified) lowest published toxic concentration: 100 mg/m3/4HEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVN1* -,38,1998
inhalation/mouse lethal concentration (50 percent kill): 1200 mg/m3/2HLung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Other changes
ENVRAL 31,138,1983
inhalation/rat lethal concentration (50 percent kill): 2300 mg/m3/2HLung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Other changes
ENVRAL 31,138,1983
intraperitoneal/mouse lethal dose (50 percent kill): 117 mg/kgCOREAF 257,791,1963
oral/man lowest published lethal dose: 714 mg/kgBehavioral: General anesthetic

Gastrointestinal: Ulceration or bleeding from small intestine

Gastrointestinal: Other changes
YAKUD5 32,570,1990
oral/mouse lethal dose (50 percent kill): 6600 mg/kgGTPZAB 20(11),55,1976
oral/mouse lethal dose (50 percent kill): 6600 mg/kgOlfaction: Change in sensation of smell

Lung, Thorax, or Respiration: Dyspnea
VCVN1* -,37,1998
oral/rat lethal dose (50 percent kill): 4090 mg/kg28ZPAK -,8,1972
subcutaneous/mouse lethal dose (50 percent kill): 2210 mg/kgVCVN1* -,36,1998

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 16200 µg/m3/17W- intermittentOlfaction: Change in sensation of smell

Vascular: BP elevation not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory depression
GTPZAB 20(11),55,1976
inhalation/rat lowest published toxic concentration: 16.2 mg/m3/16W- intermittentOlfaction: Change in sensation of smell

Lung, Thorax, or Respiration: Emphysema

Immunological Including Allergic: Decrease in cellular immune response
VCVN1* -,38,1998

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWHUTOX* -,683,1996

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESUnsupportedRBREV* -,326,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 68850; Number of Industries 385; Total Number of Facilities 97764; Number of Occupations 220; Total Number of Employees Exposed 2001842; Total Number of Female Employees Exposed 761463
National Occupational Hazard Survey 1974Hazard Code 68850; Number of Industries 389; Total Number of Facilities 148455; Number of Occupations 193; Total Number of Employees Exposed 1143671

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
TOP