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Registry of Toxic Effects of Chemical Substances (RTECS)

Sodium

RTECS #

VY0686000

CAS #

7440-23-5

Updated

August 2009

Molecular Weight

22.99

Molecular Formula

Na

Synonyms

Natrium

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 4 gm/kg85IXA4 -,704,1948

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 1687.5 mg/kg/180D- continuousCardiac: Changes in heart weight

Gastrointestinal: Other changes

Blood: Changes in cell count (unspecified)
VCVN1* -,36,1988
oral/rat lowest published toxic dose: 1575 mg/kg/12W- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Metabolism (intermediary): Effect on mitochondrial function

Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS
VCVN1* -,36,1988
oral/rat lowest published toxic dose: 70552 mg/kg/4W- continuousCardiac: Other changes

Vascular: BP elevation not characterized in autonomic section

Kidney, Ureter, and Bladder: Changes in kidney weight
BJPCBM 152,903,2007
oral/rat lowest published toxic dose: 37481 mg/kg/2W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainBJPCBM 152,903,2007

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWENTOX* -,60,2005
TOXICOLOGY REVIEWHTOPA* 1,595,2002

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 68765; Number of Industries 179; Total Number of Facilities 23017; Number of Occupations 79; Total Number of Employees Exposed 262032; Total Number of Female Employees Exposed 34622
National Occupational Hazard Survey 1974Hazard Code 68765; Number of Industries 7; Total Number of Facilities 381; Number of Occupations 9; Total Number of Employees Exposed 3325

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #ID122
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