Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Silicic acid, tetraethyl ester

RTECS #

VV9450000

CAS #

78-10-4

Updated

September 201

Molecular Weight

208.37

Molecular Formula

C8H20O4Si

Synonyms

Ethyl orthosilicate
Ethyl silicate
Ethyl silicate (ACGIH:OSHA)
Etylu krzemian (Polish)
Silane, tetraethoxy-
Silicate d'ethyle (French)
Silicate tetraethylique (French)
TEOS
Tetraethoxysilane
Tetraethyl orthosilicate
Tetraethylsilikat (Czech)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /guinea pig 2500 ppm/2H severeJIHTAB 22,288,1940
eye /human 3000 ppmJIHTAB 22,288,1940
eye /rabbit 100 mg mildUCDS** 7/23/1970
eye /rabbit 500 mg/24H mild85JCAE -,1231,1986
skin /rabbit 500 mg/24H moderateUCDS** 7/23/1970

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: >5.9 gm/m3/3HBehavioral: Ataxia

Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Changes in structure or function of salivary glands
TPKVAL 5,192,1963
inhalation/guinea pig Lowest published lethal concentration: 10 gm/m3/3HPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Eye: Corneal damage

Behavioral: Tremor
TPKVAL 5,192,1963
inhalation/guinea pig Lowest published lethal concentration: 21 gm/m3/2HBrain and Coverings: Changes in circulation

Behavioral: Ataxia

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 5,192,1963
inhalation/guinea pig Lowest published lethal concentration: 700 ppm/6HBehavioral: General anesthetic

Lung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Interstitial nephritis
JIHTAB 22,288,1940
inhalation/mammal (species unspecified) Lowest published lethal concentration: 4500 mg/m3Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Fatty liver degeneration

Blood: Other changes
TPKVAL 3,81,1961
inhalation/mammal (species unspecified) Lowest published lethal concentration: 4.5 gm/m3Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
TPKVAL 3,81,1961
inhalation/mammal (species unspecified) lowest published toxic concentration: 3.2 gm/m3TPKVAL 3,81,1961
inhalation/mouse lethal concentration (50 percent kill): 30 gm/m3Behavioral: Ataxia

Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Changes in structure or function of salivary glands
TPKVAL 5,192,1963
inhalation/mouse Lowest published lethal concentration: 20 gm/m3Kidney, Ureter, and Bladder: Interstitial nephritis

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
TPKVAL 5,192,1963
inhalation/mouse Lowest published lethal concentration: 50 gm/m3/2HBehavioral: Toxic psychosis

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis
TPKVAL 3,18,1961
inhalation/mouse Lowest published lethal concentration: 10 gm/m3/2HBrain and Coverings: Changes in circulation

Brain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)
TPKVAL 3,18,1961
inhalation/mouse Lowest published lethal concentration: 30 gm/m3/2HLiver: Other changes

Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney

Blood: Changes in spleen
TPKVAL 3,18,1961
inhalation/mouse Lowest published lethal concentration: 20 gm/m3/2HCardiac: Other changes

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Respiratory obstruction
TPKVAL 3,18,1961
inhalation/mouse Lowest published lethal concentration: 60 gm/m3Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor
TPKVAL 5,192,1963
inhalation/mouse Lowest published lethal concentration: 1 gm/m3/2HBehavioral: General anesthetic

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 5,192,1963
inhalation/rat Lowest published lethal concentration: 9 gm/m3/4HLiver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Normocytic anemia
TPKVAL 3,10,1961
inhalation/rat lowest published toxic concentration: 21 gm/m3/2HEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Dyspnea
TPKVAL 3,10,1961
inhalation/rat Lowest published lethal concentration: 21 gm/m3/3HVascular: Other changes

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Acute pulmonary edema
TPKVAL 3,10,1961
inhalation/rat Lowest published lethal concentration: 1 gm/m3/2HLiver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Hemorrhage
TPKVAL 5,192,1963
inhalation/rat Lowest published lethal concentration: 1000 ppm/4HJIHTAB 31,343,1949
inhalation/rat lowest published toxic concentration: >5.9 gm/m3/3HPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor
TPKVAL 5,192,1963
inhalation/rat Lowest published lethal concentration: 21 gm/m3/2HBrain and Coverings: Changes in circulation

Behavioral: Ataxia

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 5,192,1963
inhalation/rat Lowest published lethal concentration: 10 gm/m3/3HPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Eye: Corneal damage

Behavioral: Tremor
TPKVAL 5,192,1963
intraperitoneal/mouse lowest published lethal dose: 830 mg/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NEZAAQ 46,231,1991
intraperitoneal/rat lowest published lethal dose: 0.6 mL/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Acute pulmonary edema
TPKVAL 3,10,1961
intravenous/rabbit lowest published lethal dose: 0.02 mL/kgPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: General anesthetic

Behavioral: Tremor
TPKVAL 3,10,1961
intravenous/rabbit lowest published lethal dose: 0.2 mL/kgLung, Thorax, or Respiration: Other changes

Vascular: Structural changes in vessels

Blood: Hemorrhage
INMEAF 6,660,1937
intravenous/rabbit lowest published lethal dose: 400 mg/kgLung, Thorax, or Respiration: Pleural effusion

Kidney, Ureter, and Bladder: Interstitial nephritis

Blood: Other hemolysis with or without anemia
INMEAF 6,660,1937
intravenous/rat lowest published lethal dose: 0.6 mL/kgLung, Thorax, or Respiration: Other changes

Vascular: Structural changes in vessels

Blood: Hemorrhage
INMEAF 6,660,1937
oral/rat lowest published lethal dose: 2800 mg/kgKidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 18,425,1992
oral/rat lowest published toxic dose: 0.555 mg/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Kidney, Ureter, and Bladder: Other changes
FAATDF 18,425,1992
oral/rat lowest published lethal dose: 1000 mg/kgLiver: Fatty liver degeneration

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 3,10,1961
oral/rat lethal dose (50 percent kill): 6270 mg/kgJIHTAB 31,60,1949
skin/rabbit lethal dose (50 percent kill): 6300 µL/kgUCDS** 7/23/1970

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 200 ppm/6H/4W- intermittentOlfaction: Other olfaction effects

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ARTODN 68,277,1994
inhalation/mouse lowest published toxic concentration: 200 ppm/6H/2W- intermittentOlfaction: Other olfaction effects

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NEZAAQ 46,232,1991
inhalation/rat lowest published toxic concentration: 1.5 gm/m3/17D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 3,10,1961
inhalation/rat lowest published toxic concentration: 32 gm/m3/2D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTPKVAL 3,10,1961
inhalation/rat lowest published toxic concentration: 0.2 gm/m3/61D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Liver: Liver function tests impaired
TPKVAL 5,192,1963
inhalation/rat lowest published toxic concentration: 0.2 gm/m3/153D- intermittentBrain and Coverings: Other degenerative changes

Cardiac: Changes in coronary arteries

Blood: Changes in spleen
TPKVAL 5,192,1963
inhalation/rat lowest published toxic concentration: 1000 ppm/7H/3D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Hematuria

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JIHTAB 30,332,1948
oral/rat lowest published toxic dose: 1.11 mg/kg/2D- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Kidney, Ureter, and Bladder: Other changes
FAATDF 18,425,1992
oral/rat lowest published toxic dose: 2.22 mg/kg/4D- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Kidney, Ureter, and Bladder: Other changes
FAATDF 18,425,1992

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 100 ppm (850 mg/m3)DTLVS* 3,108,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 ppm (85 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 20 ppm (170 mg/m3);KZW 40 ppm (340 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 10 ppm (86 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 10 ppm (85 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 ppm (24 mg/m3), short term exposure limit 10 ppm (48 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 10 ppm (85 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 10 ppm (86 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 10 ppm (85 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 10 ppm (85 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 10 ppm (85 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 ppm (85 mg/m3);short term exposure limit 30 ppm (255 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 ppm (85 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 10 ppm (85 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 10 ppm (85 mg/m3); short term exposure limit 30 ppm (256 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 80 mg/m3, MAC(short term exposure limit) 250 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 20 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDceiling concentration 10 ppm (85 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 85 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 100 ppm (850 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 100 ppm (850 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 100 ppm (850 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 100 ppm (850 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 100 ppm (850 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 100 ppm (850 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYL SILICATE-air10H time-weighted average 10 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X4097; Number of Industries 22; Total Number of Facilities 721; Number of Occupations 26; Total Number of Employees Exposed 10422; Total Number of Female Employees Exposed 2566

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
TOP