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Silicic acid, tetraethyl ester

RTECS #: VV9450000

CAS #: 78-10-4

UPDATE: May 2009 MW: 208.37 MF: C8H20O4Si


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Ethyl orthosilicate
  2. Ethyl silicate
  3. Ethyl silicate (ACGIH:OSHA)
  4. Etylu krzemian (Polish)
  5. Silane, tetraethoxy -
  6. Silicate d'ethyle (French)
  1. Silicate tetraethylique (French)
  2. TEOS
  3. Tetraethoxysilane
  4. Tetraethyl orthosilicate
  5. Tetraethylsilikat (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
guinea pig 		2,500 ppm/2 hour severe JIHTAB 22,288,1940
eye
human 		3,000 ppm severe JIHTAB 22,288,1940
eye
rabbit 		100 mg mild UCDS** 7/23/1970
eye
rabbit 		500 mg/24 hour mild 85JCAE -,1231,1986
skin
rabbit 		500 mg/24 hour moderate UCDS** 7/23/1970


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published lethal concentration: 700 ppm/6 hour Behavioral: General anesthetic

Lung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Interstitial nephritis 		JIHTAB 22,288,1940
inhalation
guinea pig 		lowest published toxic concentration: >5.9 gm/m3/3 hour Behavioral: Ataxia

Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Changes in structure or function of salivary glands 		TPKVAL 5,192,1963
inhalation
guinea pig 		lowest published lethal concentration: 10 gm/m3/3 hour Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Eye: Corneal damage

Behavioral: Tremor 		TPKVAL 5,192,1963
inhalation
guinea pig 		lowest published lethal concentration: 21 gm/m3/2 hour Brain and Coverings: Changes in circulation

Behavioral: Ataxia

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		TPKVAL 5,192,1963
inhalation
mammal (species unspecified) 		lowest published lethal concentration: 4,500 mg/m3 Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Fatty liver degeneration

Blood: Other changes 		TPKVAL 3,81,1961
inhalation
mammal (species unspecified) 		lowest published lethal concentration: 4.5 gm/m3 Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi 		TPKVAL 3,81,1961
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 3.2 gm/m3 N/R TPKVAL 3,81,1961
inhalation
mouse 		lowest published lethal concentration: 1 gm/m3/2 hour Behavioral: General anesthetic

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		TPKVAL 5,192,1963
inhalation
mouse 		lethal concentration : 10 gm/m3/2 hour Brain and Coverings: Changes in circulation

Brain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity) 		TPKVAL 3,18,1961
inhalation
mouse 		lethal concentration : 20 gm/m3/2 hour Cardiac: Other changes

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Respiratory obstruction 		TPKVAL 3,18,1961
inhalation
mouse 		lethal concentration : 30 gm/m3/2 hour Liver: Other changes

Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney

Blood: Changes in spleen 		TPKVAL 3,18,1961
inhalation
mouse 		lethal concentration : 50 gm/m3/2 hour Behavioral: Toxic psychosis

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis 		TPKVAL 3,18,1961
inhalation
mouse 		lethal concentration : 60 gm/m3 Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor 		TPKVAL 5,192,1963
inhalation
mouse 		lethal concentration (50 percent kill): 30 gm/m3 Behavioral: Ataxia

Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Changes in structure or function of salivary glands 		TPKVAL 5,192,1963
inhalation
mouse 		lowest published lethal concentration: 20 gm/m3 Kidney, Ureter, and Bladder: Interstitial nephritis

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count 		TPKVAL 5,192,1963
inhalation
rat 		lowest published lethal concentration: 1,000 ppm/4 hour N/R JIHTAB 31,343,1949
inhalation
rat 		lowest published lethal concentration: 9 gm/m3/4 hour Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Normocytic anemia 		TPKVAL 3,10,1961
inhalation
rat 		lowest published toxic concentration: 21 gm/m3/2 hour Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Dyspnea 		TPKVAL 3,10,1961
inhalation
rat 		lowest published lethal concentration: 21 gm/m3/3 hour Vascular: Other changes

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Acute pulmonary edema 		TPKVAL 3,10,1961
inhalation
rat 		lowest published toxic concentration: >5.9 gm/m3/3 hour Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor 		TPKVAL 5,192,1963
inhalation
rat 		lowest published lethal concentration: 10 gm/m3/3 hour Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Eye: Corneal damage

Behavioral: Tremor 		TPKVAL 5,192,1963
inhalation
rat 		lowest published lethal concentration: 21 gm/m3/2 hour Brain and Coverings: Changes in circulation

Behavioral: Ataxia

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		TPKVAL 5,192,1963
inhalation
rat 		lowest published lethal concentration: 1 gm/m3/2 hour Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Hemorrhage 		TPKVAL 5,192,1963
intraperitoneal
mouse 		lowest published lethal dose: 830 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NEZAAQ 46,231,1991
intraperitoneal
rat 		lowest published lethal dose: 0.6 mL/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Acute pulmonary edema 		TPKVAL 3,10,1961
intravenous
rat 		lowest published lethal dose: 0.6 mL/kg Lung, Thorax, or Respiration: Other changes

Vascular: Structural changes in vessels

Blood: Hemorrhage 		INMEAF 6,660,1937
intravenous
rabbit 		lowest published lethal dose: 400 mg/kg Lung, Thorax, or Respiration: Pleural effusion

Kidney, Ureter, and Bladder: Interstitial nephritis

Blood: Other hemolysis with or without anemia 		INMEAF 6,660,1937
intravenous
rabbit 		lowest published lethal dose: 0.2 mL/kg Lung, Thorax, or Respiration: Other changes

Vascular: Structural changes in vessels

Blood: Hemorrhage 		INMEAF 6,660,1937
intravenous
rabbit 		lowest published lethal dose: 0.2 mL/kg Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: General anesthetic

Behavioral: Tremor 		TPKVAL 3,10,1961
oral
rat 		lethal dose (50 percent kill): 6,270 mg/kg N/R JIHTAB 31,60,1949
oral
rat 		lowest published lethal dose: 2,800 mg/kg Kidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 18,425,1992
oral
rat 		lowest published toxic dose: 0.555 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Kidney, Ureter, and Bladder: Other changes 		FAATDF 18,425,1992
oral
rat 		lowest published lethal dose: 1,000 mg/kg Liver: Fatty liver degeneration

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		TPKVAL 3,10,1961
skin
mouse 		lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation TPKVAL 5,192,1963
skin
rabbit 		lethal dose (50 percent kill): 6,300 µL/kg N/R UCDS** 7/23/1970
skin
rabbit 		lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation TPKVAL 5,192,1963


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 200 ppm/6 hour/4 week- intermittent Olfaction: Other olfaction effects

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		ARTODN 68,277,1994
inhalation
mouse 		lowest published toxic concentration: 200 ppm/6 hour/2 week- intermittent Olfaction: Other olfaction effects

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NEZAAQ 46,232,1991
inhalation
rat 		lowest published toxic concentration: 1,000 ppm/7 hour/3 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Hematuria

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JIHTAB 30,332,1948
inhalation
rat 		lowest published toxic concentration: 1.5 gm/m3/17 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TPKVAL 3,10,1961
inhalation
rat 		lowest published toxic concentration: 32 gm/m3/2 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TPKVAL 3,10,1961
inhalation
rat 		lowest published toxic concentration: 0.2 gm/m3/61 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Liver: Liver function tests impaired 		TPKVAL 5,192,1963
inhalation
rat 		lowest published toxic concentration: 0.2 gm/m3/153 day- intermittent Brain and Coverings: Other degenerative changes

Cardiac: Changes in coronary arteries

Blood: Changes in spleen 		TPKVAL 5,192,1963
oral
rat 		lowest published toxic dose: 1.11 mg/kg/2 day- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Kidney, Ureter, and Bladder: Other changes 		FAATDF 18,425,1992
oral
rat 		lowest published toxic dose: 2.22 mg/kg/4 day- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Kidney, Ureter, and Bladder: Other changes 		FAATDF 18,425,1992


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (850 mg/m3) DTLVS* 3,108,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (850 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (850 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (850 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (850 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (85 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (86 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 10 ppm (85 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 10 ppm (85 mg/m3), short term exposure limit 20 ppm (170 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 10 ppm (85 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 86 mg/m3 (10 mL/m3), 2005
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 10 ppm (85 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 10 ppm (85 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 ppm (85 mg/m3);
short term exposure limit 30 ppm (255 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 85 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 ppm (85 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 10 ppm (85 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (850 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 80 mg/m3, MAC(short term exposure limit) 250 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 20 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 10 ppm (85 mg/m3),KZG- week 10 ppm (85 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 100 ppm (850 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 10 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 10 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYL SILICATE-air 10 hour time-weighted average 10 ppm NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4097;
Number of Industries 22;
Total Number of Facilities 721;
Number of Occupations 26;
Total Number of Employees Exposed 10,422;
Total Number of Female Employees Exposed 2,566


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as mold binder for investment casting, and in corrosion-resistant coatings
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For publisher information, see IOHSA5.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as mold binder for investment casting, and in corrosion-resistant coatings

NIOSH PROFILE (ETHYL SILICATE), SRC, 12/79

RTECS Compound Description:
   Human Data
   Primary Irritant

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