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Registry of Toxic Effects of Chemical Substances (RTECS)

Silicic acid (H2SiO3), disodium salt

RTECS #

VV9275000

CAS #

6834-92-0

Updated

November 2008

Molecular Weight

122.07

Molecular Formula

O3Si·2Na

Synonyms

B-W
Crystamet
Disodium metasilicate
Disodium monosilicate
Metso 20
Metso beads 2048
Metso beads, drymet
Metso pentabead 20
Orthosil
Sodium metasilicate
Sodium metasilicate, anhydrous
Sodium silicate
Water glass

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /guinea pig 250 mg/24H moderateTXAPA9 31,481,1975
skin /human 250 mg/24H severeTXAPA9 31,481,1975
skin /mouse 4%/96HAJCDE* 13,133,2002
skin /rabbit 250 mg/24H severeTXAPA9 31,481,1975

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intratesticular/rat 9766 µg/kg (1D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductJRPFA4 7,21,1964
oral/rat 15 gm/kg (14W male/14W pre-3W after birth)Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
JANSAG 36,271,1973
subcutaneous/rat 9766 µg/kg (1D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductJRPFA4 7,21,1964

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/guinea pig lowest published lethal dose: 200 mg/kgJAMAAP 111,1925,1938
oral/Dog lowest published lethal dose: 250 mg/kgLung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
FCTXAV 14,78,1976
oral/man lowest published toxic dose: 1 mL/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Hematuria

Gastrointestinal: Nausea or vomiting
JJAMA* 17,55,1993
oral/mouse lethal dose (50 percent kill): 770 mg/kgGastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Ulceration or bleeding from duodeum

Gastrointestinal: Ulceration or bleeding from small intestine
TOLED5 31(Suppl),44,1986
oral/pig lowest published lethal dose: 250 mg/kgFCTXAV 14,78,1976
oral/rat lethal dose (50 percent kill): 1153 mg/kgGastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Ulceration or bleeding from duodeum

Gastrointestinal: Ulceration or bleeding from small intestine
TOLED5 31(Suppl),44,1986
oral/rat lethal dose (50 percent kill): >1000 mg/kgGastrointestinal: Other changesFEREAC 71,19436,2006

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 224 mg/kg/4W- continuousKidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Urine volume increased
PNASA6 65,872,1970

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWNTIS** PB-287-766
TOXICOLOGY REVIEWIJTOFN 24,103,2005
TOXICOLOGY REVIEWFEREAC 71,19436,2006

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,334,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80079; Number of Industries 281; Total Number of Facilities 59514; Number of Occupations 164; Total Number of Employees Exposed 971688; Total Number of Female Employees Exposed 275947
National Occupational Hazard Survey 1974Hazard Code 80079; Number of Industries 300; Total Number of Facilities 97326; Number of Occupations 154; Total Number of Employees Exposed 838120

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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