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Silica, crystalline - cristobalite

RTECS #: VV7325000

CAS #: 14464-46-1


UPDATE: May 2009 MW: 60.09 MF: O2Si


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 43 - 63C
  2. Calcined diatomaceous earth
  3. Calcined diatomite
  4. Cristobalite
  5. Crysvarl
  1. Metacristobalite
  2. Silica, crystalline - cristobalite (ACGIH:OSHA)
  3. W 006
  4. WGL 300
  5. alpha - Crystobalite


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intrapleural
rat
lowest published toxic dose: 90 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease
JNCIAM 57,509,1976
intrapleural
rat
toxic dose : 100 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease
BJCAAI 41,908,1980


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 16 million particles per cubic foot/8 hour/17.9 year- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea
NTIS** PB246-697
intratracheal
rat
lowest published lethal dose: 200 mg/kg Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) BJIMAG 10,9,1953
intratracheal
rat
lowest published toxic dose: 10 mg/kg Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 195,155,2004
intratracheal
rat
lowest published toxic dose: 20 mg/kg Lung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 195,155,2004


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 70 mg/m3/5 hour/12 day- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Other changes
JEPOEC 17,99,1998
inhalation
mouse
lowest published toxic concentration: 43 mg/m3/5 hour/9 day- intermittent Lung, Thorax, or Respiration: Pleural effusion

Lung, Thorax, or Respiration: Other changes
JEPOEC 17,81,1998


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.025 mg/m3 (respirable) DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 42,39,1987
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 68,41,1997
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 42,39,1987
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 68,41,1997
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMEMDT 68,41,1997
TOXICOLOGY REVIEW
ANAEA3 35,165,1975
TOXICOLOGY REVIEW
31BYAP -,93,1974


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - respirable dust in air time-weighted average 10 mg/m3/2(% resp. SiO2+2) DTLWS* 3,33,1973
Mine Safety and Health Administration (MSHA) STANDARD - total dust in air time-weighted average 30 mg/m3/2(% SiO2+3) DTLWS* 3,33,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3/(% resp SiO2+2) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3/(% resp SiO2+2) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 20 million particles per cubic foot/(%SiO2+5) CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 mg/m3 (resp. dust), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.05 mg/m3 (respirable), OCT 2002
Occupational Exposure Limit - DENMARK time-weighted average 0.15 mg/m3 (total dust), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.05 mg/m3, (resp), FEB2006
Occupational Exposure Limit - JAPAN Occupational Exposure Limit- continuous 0.03 mg/m3 (respirable), APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.05 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.05 mg/m3 (respirable), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.075 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg/m3 (respirable dust), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.05 mg/m3 (resp.), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3 (total dust), JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.05 mg/m3 (resp. dust), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.15 mg/m3, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.3 mg/m3 (respirable), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.025 mg/m3 (respirable)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.025 mg/m3 (respirable)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SILICA, cryst. cristobalite-air Carcinogen;
10 hour time-weighted average 0.05 mg/m3
NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T0624;
Number of Industries 33;
Total Number of Facilities 2,072;
Number of Occupations 43;
Total Number of Employees Exposed 31,369;
Total Number of Female Employees Exposed 2,228


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of water glass, refractories, abrasives, ceramics and enamels
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Silica, crystalline, by XRD, 7500; by VIS, 7600; by IR, 7602
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
OSHA ANALYTICAL METHOD #ID-125G, SUPERSEDED BY ID142


REFERENCES:

CODEN
REFERENCE

31BYAP "Experimental Lung Cancer: Carcinogenesis and Bioassays, International Symposium, 1974," Karbe, E., and J.F. Park, eds., Springer-Verlag New York, Inc., 1974
ANAEA3 Annals of Allergy. (American College of Allergists, POB 20671, Bloomington, MN 55420) V.1- 1943-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used in the manufacture of water glass, refractories, abrasives, ceramics and enamels

NIOSH PROFILE (DENTISTRY), SRC, 2/80

RTECS Compound Description:
   Tumorigen
   Human Data

ALT CAS #: 1317-48-2
ALT CAS #: 105269-70-3
Click Here for Additional Information about RTECS

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