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Registry of Toxic Effects of Chemical Substances (RTECS)

Silane, trichloro-

RTECS #

VV5950000

CAS #

10025-78-2

Updated

April 2012

Molecular Weight

135.45

Molecular Formula

Cl3HSi

Synonyms

Silane A-19
Silici-chloroforme (French)
Siliciumchloroform (German)
Silicochloroform
Trichloorsilaan (Dutch)
Trichloromonosilane
Trichlorsilan (German)
Triclorosilano (Italian)

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 1 gm/m3Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Fatty liver degeneration

Blood: Other changes
TPKVAL 3,81,1961
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 1 gm/m3Blood: HemorrhageTPKVAL 3,81,1961
inhalation/mammal (species unspecified) Lowest published lethal concentration: 0.8 gm/m3Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
TPKVAL 3,81,1961
inhalation/mammal (species unspecified) lowest published toxic concentration: 0.5 gm/m3Behavioral: Convulsions or effect on seizure threshold

Vascular: Other changes

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance
TPKVAL 3,81,1961
inhalation/mouse lowest published toxic concentration: 0.8 gm/m3/2HTPKVAL 3,73,1961
inhalation/mouse Lowest published lethal concentration: 1.02 gm/m3/2HSkin: After systemic exposure: Dermatitis, otherTPKVAL 3,73,1961
inhalation/mouse lethal concentration (50 percent kill): 1.52 gm/m3/2HEye: Conjunctiva irritation

Eye: Corneal damage
TPKVAL 3,73,1961
inhalation/mouse lethal concentration (50 percent kill): 1500 mg/m3/2H85GMAT -,114,1982
inhalation/mouse Lowest published lethal concentration: 1.22 gm/m3/2HPeripheral Nerve and Sensation: Recording from peripheral motor nerveTPKVAL 3,73,1961
inhalation/rat Lowest published lethal concentration: 500 ppm/4HUCDS** 2/21/1979
ocular/rabbit lowest published toxic dose: 100 pphEye: Conjunctiva irritation

Eye: Corneal damage
TPKVAL 3,73,1961
ocular/rabbit lowest published toxic dose: 100 pphEye: Other eye effectsTPKVAL 3,81,1961
oral/rat lethal dose (50 percent kill): 1030 mg/kgJIHTAB 31,60,1949

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 0.025 gm/m3/182D- intermittentBehavioral: Somnolence (general depressed activity)

Cardiac: Other changes

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
TPKVAL 3,73,1961

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWCHHSA* 9,6,2002

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X3556; Number of Industries 3; Total Number of Facilities 23; Number of Occupations 4; Total Number of Employees Exposed 2201; Total Number of Female Employees Exposed 267

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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