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Silane, methyltrichloro -

RTECS #: VV4550000

CAS #: 75-79-6


UPDATE: February 2008 MW: 149.48 MF: CH3Cl3Si


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. KA 13
  2. LS 40 (silane)
  3. Methyl - trichlorsilan (Czech)
  4. Methylsilicochloroform
  5. Methylsilyl trichloride
  1. Methylsilicon trichloride
  2. Silane, trichloromethyl -
  3. Trichlor - methylsilan (Czech)
  4. Trichloromethylsilicon
  5. Trichloromethylsilane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
5 mg/24 hour severe 85JCAE -,1219,1986
skin
rabbit
500 ÁL severe ATDAEI 12,571,1993


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 0.18 gm/m3 Behavioral: Convulsions or effect on seizure threshold

Vascular: Other changes

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance
TPKVAL 3,81,1961
inhalation
mammal (species unspecified)
lowest published lethal concentration: 0.12 gm/m3 Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
TPKVAL 3,81,1961
inhalation
mammal (species unspecified)
lowest published toxic concentration: 0.1 gm/m3 N/R TPKVAL 3,81,1961
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 0.18 gm/m3 N/R TPKVAL 5,182,1963
inhalation
mammal (species unspecified)
lowest published lethal concentration: 0.12 gm/m3 N/R TPKVAL 5,182,1963
inhalation
mouse
lethal concentration (50 percent kill): 180 mg/m3/2 hour N/R TPKVAL 3,23,1961
inhalation
mouse
lethal concentration : 0.12 gm/m3/2 hour Brain and Coverings: Changes in circulation

Brain and Coverings: Other degenerative changes

Eye: Conjunctiva irritation
TPKVAL 3,23,1961
inhalation
mouse
lethal concentration : 0.18 gm/m3/2 hour N/R TPKVAL 3,23,1961
inhalation
rat
lethal concentration (50 percent kill): 450 ppm/4 hour N/R 85JCAE -,1219,1986
intraperitoneal
rat
lowest published lethal dose: 30 mg/kg N/R JIHTAB 30,332,1948
ocular
rabbit
lowest published toxic dose: 100 pph Eye: Conjunctiva irritation

Eye: Corneal damage

Eye: Other eye effects
TPKVAL 3,23,1961
ocular
rabbit
lowest published toxic dose: 100 pph Eye: Conjunctiva irritation

Eye: Corneal damage
TPKVAL 3,81,1961
oral
rat
lethal dose (50 percent kill): 1,620 ÁL/kg Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes
ATDAEI 12,571,1993
skin
mouse
lowest published toxic dose: 100 pph/1 minute Skin: After topical application: Primary irritation TPKVAL 3,81,1961
skin
rabbit
lethal dose (50 percent kill): 840 ÁL/kg Behavioral: Altered sleep time (including change in righting reflex)

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ATDAEI 12,571,1993
skin
rabbit
lowest published toxic dose: 100 pph/3 minute Skin: After topical application: Primary irritation TPKVAL 3,23,1961
skin
rabbit
lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation TPKVAL 3,81,1961


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83302;
Number of Industries 1;
Total Number of Facilities 10;
Number of Occupations 1;
Total Number of Employees Exposed 60
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83302;
Number of Industries 2;
Total Number of Facilities 63;
Number of Occupations 6;
Total Number of Employees Exposed 1,755;
Total Number of Female Employees Exposed 1,191


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

Used as intermediate in production of silicones

NIOSH PROFILE (SILICON COMPOUNDS, ORGANIC), SRC, 12/79

RTECS Compound Description:
   Primary Irritant

ALT CAS #: 175446-71-6
Click Here for Additional Information about RTECS

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