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Registry of Toxic Effects of Chemical Substances (RTECS)

Silane, methyltrichloro-

RTECS #

VV4550000

CAS #

75-79-6; 175446-71-6

Updated

April 2012

Molecular Weight

149.48

Molecular Formula

CH3Cl3Si

Synonyms

KA 13
LS 40 (silane)
Methylsilicochloroform
Methylsilicon trichloride
Methylsilyl trichloride
Methyl-trichlorsilan (Czech)
Silane, trichloromethyl-
Trichlor-methylsilan (Czech)
Trichloromethylsilane
Trichloromethylsilicon

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 5 mg/24H severe85JCAE -,1219,1986
skin /rabbit 500 µL severeATDAEI 12,571,1993

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 0.18 gm/m3Behavioral: Convulsions or effect on seizure threshold

Vascular: Other changes

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance
TPKVAL 3,81,1961
inhalation/mammal (species unspecified) Lowest published lethal concentration: 0.12 gm/m3Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
TPKVAL 3,81,1961
inhalation/mammal (species unspecified) lowest published toxic concentration: 0.1 gm/m3TPKVAL 3,81,1961
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 0.18 gm/m3TPKVAL 5,182,1963
inhalation/mammal (species unspecified) Lowest published lethal concentration: 0.12 gm/m3TPKVAL 5,182,1963
inhalation/mouse Lowest published lethal concentration: 0.12 gm/m3/2HBrain and Coverings: Changes in circulation

Brain and Coverings: Other degenerative changes

Eye: Conjunctiva irritation
TPKVAL 3,23,1961
inhalation/mouse Lowest published lethal concentration: 0.18 gm/m3/2HTPKVAL 3,23,1961
inhalation/mouse lethal concentration (50 percent kill): 180 mg/m3/2HTPKVAL 3,23,1961
inhalation/rat lethal concentration (50 percent kill): 450 ppm/4H85JCAE -,1219,1986
intraperitoneal/rat lowest published lethal dose: 30 mg/kgJIHTAB 30,332,1948
ocular/rabbit lowest published toxic dose: 100 pphEye: Conjunctiva irritation

Eye: Corneal damage

Eye: Other eye effects
TPKVAL 3,23,1961
ocular/rabbit lowest published toxic dose: 100 pphEye: Conjunctiva irritation

Eye: Corneal damage
TPKVAL 3,81,1961
oral/rat lethal dose (50 percent kill): 1620 µL/kgLung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes
ATDAEI 12,571,1993
skin/rabbit lethal dose (50 percent kill): 840 µL/kgBehavioral: Altered sleep time (including change in righting reflex)

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ATDAEI 12,571,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83302; Number of Industries 2; Total Number of Facilities 63; Number of Occupations 6; Total Number of Employees Exposed 1755; Total Number of Female Employees Exposed 1191
National Occupational Hazard Survey 1974Hazard Code 83302; Number of Industries 1; Total Number of Facilities 10; Number of Occupations 1; Total Number of Employees Exposed 60

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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