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Registry of Toxic Effects of Chemical Substances (RTECS)

Silane, dichlorodimethyl-

RTECS #

VV3150000

CAS #

75-78-5

Updated

April 2012

Molecular Weight

129.07

Molecular Formula

C2H6Cl2Si

Synonyms

Dichlorodimethylsilane
Dichlorodimethylsilicon
Dimethyl-dichlorsilan (Czech)
Dimethylsilane dichloride
Inerton AW-DMCS
LS 130
Repel-Silan

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 5 mg/24H severe85JCAE -,1219,1986
skin /rabbit 20 mg/24H moderate85JCAE -,1219,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 0.3 gm/m3Behavioral: Convulsions or effect on seizure threshold

Vascular: Other changes

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance
TPKVAL 3,81,1961
inhalation/mammal (species unspecified) Lowest published lethal concentration: 0.14 gm/m3Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
TPKVAL 3,81,1961
inhalation/mammal (species unspecified) lowest published toxic concentration: 0.08 gm/m3TPKVAL 3,81,1961
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 0.3 gm/m3TPKVAL 5,182,1963
inhalation/mammal (species unspecified) Lowest published lethal concentration: 0.14 gm/m3TPKVAL 5,182,1963
inhalation/mouse Lowest published lethal concentration: 0.14 gm/m3/2HBehavioral: Stiffness

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Respiratory obstruction
TPKVAL 3,23,1961
inhalation/mouse Lowest published lethal concentration: 0.22 gm/m3/2HTPKVAL 3,23,1961
inhalation/mouse lethal concentration (50 percent kill): 20.8 gm/m3Brain and Coverings: Changes in circulation

Eye: Corneal damage

Behavioral: Sleep
TPKVAL 5,149,1963
inhalation/mouse lethal concentration (50 percent kill): 300 mg/m3/2HTPKVAL 3,23,1961
inhalation/rat lethal concentration (50 percent kill): 930 ppm/4H85JCAE -,1219,1986
intraperitoneal/rat lowest published lethal dose: 10 mg/kgJIHTAB 30,332,1948
ocular/rabbit lowest published toxic dose: 100 pphEye: Conjunctiva irritation

Eye: Corneal damage

Eye: Other eye effects
TPKVAL 3,23,1961
ocular/rabbit lowest published toxic dose: 100 pphEye: Conjunctiva irritation

Eye: Corneal damage
TPKVAL 3,81,1961
oral/rat lethal dose (50 percent kill): 5660 µL/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Liver: Other changes
ATDAEI 12,573,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83986; Number of Industries 2; Total Number of Facilities 26; Number of Occupations 4; Total Number of Employees Exposed 738; Total Number of Female Employees Exposed 69
National Occupational Hazard Survey 1974Hazard Code 83986; Number of Industries 2; Total Number of Facilities 54; Number of Occupations 2; Total Number of Employees Exposed 170

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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