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Registry of Toxic Effects of Chemical Substances (RTECS)

Silane, chlorotrimethyl-

RTECS #

VV2710000

CAS #

75-77-4

Updated

October 1997

Molecular Weight

108.66

Molecular Formula

C3H9ClSi

Synonyms

Chlorotrimethylsilane
Silane, trimethylchloro-
Silicane, chlorotrimethyl-
TL 1163
Trimethyl chlorosilane
Trimethylsilyl chloride

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 5 µL moderateATDAEI 12,574,1993
skin /rabbit 500 µL moderateATDAEI 12,574,1993

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium1 mg/plate (+enzymatic activation step)ENMUDM 8(Suppl 7),1,1986

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 1000 mg/kgTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
JNCIAM 54,495,1975

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lowest published lethal concentration: 100 mg/m3USKHAB 38,2173,1969
intraperitoneal/mouse lowest published lethal dose: 750 mg/kgImmunological Including Allergic: Decreased immune responseStoGD# 27MAY1975
oral/rat lethal dose (50 percent kill): 5660 µL/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Other changes
ATDAEI 12,574,1993
skin/rabbit lethal dose (50 percent kill): 1780 µL/kgBehavioral: Altered sleep time (including change in righting reflex)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ATDAEI 12,574,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83272; Number of Industries 2; Total Number of Facilities 8; Number of Occupations 15; Total Number of Employees Exposed 1876; Total Number of Female Employees Exposed 20
National Occupational Hazard Survey 1974Hazard Code 83272; Number of Industries 3; Total Number of Facilities 59; Number of Occupations 4; Total Number of Employees Exposed 200

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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