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Sebacic acid

RTECS #: VS0875000

CAS #: 111-20-6


UPDATE: February 2006 MW: 202.28 MF: C10H18O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 1,10 - Decanedioic acid
  2. 1,8 - Octanedicarboxylic acid
  3. Acide sebacique (French)
  4. Decanedioic acid
  1. Sebacinsaure (German)
  2. USAF HC - 1
  3. n - Decanedioic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lethal concentration : >900 mg/m3 Olfaction: Other olfaction effects

Behavioral: Excitement
GTPZAB 24(5),48,1980
inhalation
rat
lethal concentration (50 percent kill): >4,500 mg/m3 N/R GISAAA 57(2),17,1992
intraperitoneal
mammal (species unspecified)
lethal dose (50 percent kill): 1,175 mg/kg N/R GTPZAB 24(5),48,1980
intraperitoneal
mouse
lethal dose (50 percent kill): 500 mg/kg N/R NTIS** AD277-689
oral
mammal (species unspecified)
lethal dose (50 percent kill): >11 gm/kg N/R GISAAA 48(9),72,1983
oral
mouse
lethal dose (50 percent kill): 6 gm/kg Tumorigenic: Active as anti-cancer agent BIJOAK 34,1196,1940
oral
rat
lethal dose (50 percent kill): 14,375 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Food intake (animal)
GISAAA 57(2),17,1992


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 460 g/m3/24 hour/17 week- continuous Liver: Liver function tests impaired

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 57(2),17,1992
inhalation
rat
lowest published toxic concentration: 410 mg/m3/30 day- intermittent Brain and Coverings: Recordings from specific areas of CNS

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
GTPZAB 24(5),48,1980
oral
rat
lowest published toxic dose: 2,887 mg/kg/33 week- intermittent Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
GISAAA 48(9),72,1983


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 4 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84426;
Number of Industries 9;
Total Number of Facilities 275;
Number of Occupations 14;
Total Number of Employees Exposed 2,129
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84426;
Number of Industries 17;
Total Number of Facilities 1,720;
Number of Occupations 35;
Total Number of Employees Exposed 51,959;
Total Number of Female Employees Exposed 2,762


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

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