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Registry of Toxic Effects of Chemical Substances (RTECS)

Sebacic acid

RTECS #

VS0875000

CAS #

111-20-6

Updated

February 2006

Molecular Weight

202.28

Molecular Formula

C10H18O4

Synonyms

1,10-Decanedioic acid
1,8-Octanedicarboxylic acid
Acide sebacique (French)
Decanedioic acid
n-Decanedioic acid
Sebacinsaure (German)
USAF HC-1

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) Lethal concentration: >900 mg/m3Olfaction: Other olfaction effects

Behavioral: Excitement
GTPZAB 24(5),48,1980
inhalation/rat lethal concentration (50 percent kill): >4500 mg/m3GISAAA 57(2),17,1992
intraperitoneal/mammal (species unspecified) lethal dose (50 percent kill): 1175 mg/kgGTPZAB 24(5),48,1980
intraperitoneal/mouse lethal dose (50 percent kill): 500 mg/kgNTIS** AD277-689
oral/mammal (species unspecified) lethal dose (50 percent kill): >11 gm/kgGISAAA 48(9),72,1983
oral/mouse lethal dose (50 percent kill): 6 gm/kgTumorigenic: Active as anti-cancer agentBIJOAK 34,1196,1940
oral/rat lethal dose (50 percent kill): 14375 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Food intake (animal)
GISAAA 57(2),17,1992

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 460 µg/m3/24H/17W- continuousLiver: Liver function tests impaired

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 57(2),17,1992
inhalation/rat lowest published toxic concentration: 410 mg/m3/30D- intermittentBrain and Coverings: Recordings from specific areas of CNS

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
GTPZAB 24(5),48,1980
oral/rat lowest published toxic dose: 2887 mg/kg/33W- intermittentLiver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
GISAAA 48(9),72,1983

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 4 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84426; Number of Industries 17; Total Number of Facilities 1720; Number of Occupations 35; Total Number of Employees Exposed 51959; Total Number of Female Employees Exposed 2762
National Occupational Hazard Survey 1974Hazard Code 84426; Number of Industries 9; Total Number of Facilities 275; Number of Occupations 14; Total Number of Employees Exposed 2129

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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