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Registry of Toxic Effects of Chemical Substances (RTECS)

Selenium(IV) dioxide (1:2)

RTECS #

VS8575000

CAS #

7446-08-4

Updated

July 2013

Molecular Weight

110.96

Molecular Formula

O2Se

Synonyms

RCRA waste number U204
Selenious anhydride
Selenium oxide (1:2)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA repair/Bacillus subtilis10 mmol/LMUREAV 77,109,1980
micronucleus testleukocyte/other fish50 µg/LMUREAV 320,157,1994

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 2160 µg/kg (90D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductIJPPAZ 27,237,1983
subcutaneous/gerbil 5600 µg/kg (1D male)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
JRMSAS 85,297,1965

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 60 mg/m3Lung, Thorax, or Respiration: Acute pulmonary edemaVCVN5* -,267,1993
inhalation/rat Lowest published lethal concentration: 150 mg/m3HBTME* -,783,2007
intraperitoneal/mouse lethal dose (50 percent kill): 4300 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
intraperitoneal/rat lethal dose (50 percent kill): 3600 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
intratracheal/rat lowest published lethal dose: 7.5 mg/kgVCVN5* -,266,1993
intratracheal/rat lowest published lethal dose: 7.5 mg/kgLung, Thorax, or Respiration: Other changesVCVN5* -,267,1993
intravenous/mouse lethal dose (50 percent kill): 9200 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
intravenous/rat lethal dose (50 percent kill): 2710 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
oral/mouse lethal dose (50 percent kill): 23300 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
oral/rat lethal dose (50 percent kill): 68100 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
oral/woman lowest published toxic dose: 40 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Nausea or vomiting
HBTME* -,783,2007
subcutaneous/gerbil lowest published lethal dose: 7500 µg/kgJRMSAS 85,297,1965
subcutaneous/mouse lowest published lethal dose: 0.005 mg/kgVCVN5* -,266,1993
subcutaneous/rabbit lethal dose (50 percent kill): 4 mg/kgVCVN5* -,266,1993
subcutaneous/rabbit lowest published lethal dose: 0.005 mg/kgVCVN5* -,266,1993

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 3 mg/m3/6H/4W- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVN5* -,271,1989
inhalation/rat lowest published toxic concentration: 5500 ng/kg/13W- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
GISAAA 40(10),14,1975
oral/domestic animal lowest published toxic dose: 780 µg/kg/26W- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
EVMJB9 46,189,1986
oral/rat lowest published toxic dose: 160 mg/kg/40D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count
KHZDAN 13,174,1970

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWHBTME* ,783,2007

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.2 mg(Se)/m3DTLVS* 3,224,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.2 mg(Se)/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg(Se)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.2 mg(Se)/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 mg(Se)/m3, MAY2011
Occupational Exposure Limit-GERMANYMAK 0.02 mg(Se)/m3, inhal, skin, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg(Se)/m3, short term exposure limit 0.4 mg(Se)/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 mg(Se)/m3, MAY2012
Occupational Exposure Limit-MEXICOtime-weighted average 0.2 mg(Se)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg(Se)/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg(Se)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.1 mg(Se)/m3, MAC(short term exposure limit) 0.3 mg(Se)/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.1 mg(Se)/m3 (total dust), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.02 mg(Se)/m3, KZG-week 0.16 mg(Se)/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.2 mg(Se)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.2 mg(Se)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg(Se)/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.2 mg(Se)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.2 mg(Se)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.2 mg(Se)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.2 mg(Se)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84447; Number of Industries 10; Total Number of Facilities 237; Number of Occupations 17; Total Number of Employees Exposed 5207; Total Number of Female Employees Exposed 823
National Occupational Hazard Survey 1974Hazard Code 84447; Number of Industries 5; Total Number of Facilities 225; Number of Occupations 6; Total Number of Employees Exposed 795

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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