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Selenium (IV) dioxide (1:2)

RTECS #: VS8575000

CAS #: 7446-08-4


UPDATE: May 2009 MW: 110.96 MF: O2Se


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. RCRA waste number U204
  2. Selenious anhydride
  1. Selenium oxide (1:2)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA repair Bacillus subtilis 10 mmol/L MUREAV 77,109,1980
micronucleus test other fish leukocyte 50 g/L MUREAV 320,157,1994


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 2,160 g/kg (90 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct IJPPAZ 27,237,1983
subcutaneous
gerbil
lowest published toxic dose: 5,600 g/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
JRMSAS 85,297,1965


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published lethal concentration: 60 mg/m3 Lung, Thorax, or Respiration: Acute pulmonary edema VCVN5* -,267,1993
inhalation
rat
lowest published lethal concentration: 150 mg/m3 N/R HBTME* -,783,2007
intraperitoneal
mouse
lethal dose (50 percent kill): 4,300 g/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
intraperitoneal
rat
lethal dose (50 percent kill): 3,600 g/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
intratracheal
rat
lowest published lethal dose: 7.5 mg/kg N/R VCVN5* -,266,1993
intratracheal
rat
lowest published lethal dose: 7.5 mg/kg Lung, Thorax, or Respiration: Other changes VCVN5* -,267,1993
intravenous
mouse
lethal dose (50 percent kill): 9,200 g/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
intravenous
rat
lethal dose (50 percent kill): 2,710 g/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
oral
mouse
lethal dose (50 percent kill): 23,300 g/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
oral
rat
lethal dose (50 percent kill): 68,100 g/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
oral
woman
lowest published toxic dose: 40 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Nausea or vomiting
HBTME* -,783,2007
subcutaneous
gerbil
lowest published lethal dose: 7,500 g/kg N/R JRMSAS 85,297,1965
subcutaneous
mouse
lowest published lethal dose: 0.5 mg/kg N/R VCVN5* -,266,1993
subcutaneous
rabbit
lethal dose (50 percent kill): 4 mg/kg N/R VCVN5* -,266,1993
subcutaneous
rabbit
lowest published lethal dose: 0.5 mg/kg N/R VCVN5* -,266,1993


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lowest published toxic concentration: 3 mg/m3/6 hour/4 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVN5* -,271,1989
inhalation
rat
lowest published toxic concentration: 5,500 ng/kg/13 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
GISAAA 40(10),14,1975
oral
domestic animal
lowest published toxic dose: 780 g/kg/26 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
EVMJB9 46,189,1986
oral
rat
lowest published toxic dose: 160 mg/kg/40 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count
KHZDAN 13,174,1970


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg(Se)/m3 DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
HBTME* ,783,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.2 mg(Se)/m3 DTLVS* 3,224,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.2 mg(Se)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.2 mg(Se)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.2 mg(Se)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.2 mg(Se)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.2 mg(Se)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg(Se)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg(Se)/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg(Se)/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg(Se)/m3, short term exposure limit 0.3 mg(Se)/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.05 mg(Se)/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg(Se)/m3, short term exposure limit 0.4 mg(Se)/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 mg(Se)/m3, APR2007
Occupational Exposure Limit - MEXICO time-weighted average 0.2 mg(Se)/m3, 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg(Se)/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg(Se)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.2 mg(Se)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.1 mg(Se)/m3, MAC(short term exposure limit) 0.3 mg(Se)/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.1 mg(Se)/m3 (total dust), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 mg(Se)/m3,KZG- week 0.2 mg(Se)/m3, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 0.2 mg(Se)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg(Se)/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.2 mg(Se)/m3
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.2 mg(Se)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84447;
Number of Industries 5;
Total Number of Facilities 225;
Number of Occupations 6;
Total Number of Employees Exposed 795
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84447;
Number of Industries 10;
Total Number of Facilities 237;
Number of Occupations 17;
Total Number of Employees Exposed 5,207;
Total Number of Female Employees Exposed 823


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EVMJB9 Journal of the Egyptian Veterinary Medical Association. (Egyptian Veterinary Medical Association, 8, 26 July St., Cairo, Egypt) V.27- 1967-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBTME*
IJPPAZ Indian Journal of Physiology and Pharmacology. (All India Institute of Medical Sciences, Dept. of Physiology, Ansari Nagar, New Delhi 110 029, India) V.1- 1957-
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
JRMSAS Journal of the Royal Microscopical Society. (London, UK) V.47-88, 1927-68. For publisher information, see JMICAR.
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used as oxidizing agent in synthesis of organic chemicals and pharmaceuticals

NIOSH PROFILE (SELENIUM AND ITS COMPOUND), SRC, 4/78

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data

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