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Registry of Toxic Effects of Chemical Substances (RTECS)

Selenious acid, disodium salt

RTECS #

VS7350000

CAS #

10102-18-8

Updated

July 2013

Molecular Weight

172.94

Molecular Formula

O3Se·2Na

Synonyms

Disodium selenite
Natriumselenit (German)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human80 µmol/LMUREAV 224,503,1989
Cytogenetic Analysisfibroblast/human80 µmol/LBTERDG 2,81,1980
Cytogenetic Analysislymphocyte/rat7500 nmol/LMUREAV 169,61,1986
Cytogenetic Analysisintravenous/rat10 mg/kgMUREAV 169,61,1986
Cytogenetic Analysisoral/mouse7 mg/kgMUREAV 390,201,1997
Cytogenetic Analysisintraperitoneal/hamster6650 µg/kgHEREAY 93,101,1980
DNA Damageleukocyte/mouse20 µmol/LBCPCA6 43,1137,1992
DNA Damagelymphocyte/human100 mmol/L/30MTCMUD8 23(Suppl 2),53,2003
DNA Damagefibroblast/human50 µmol/LMUREAV 193,237,1988
DNA inhibitionfibroblast/human80 µmol/LMUREAV 49,305,1978
DNA inhibitionHeLa cell/human10 µmol/LAEMBAP 177,229,1984
DNA repair/Salmonella typhimurium10 µg/plateCALEDQ 10,75,1980
DNA repair/Bacillus subtilis50 µmol/plateMUREAV 66,175,1979
DNA repairother cell types/human0.01 µmol/L/1HMUREAV 565,45,2004
gene conversion and mitotic recombination/Saccharomyes cerevisiae300 µmol/LMUREAV 204,605,1988
mutation in microorganisms/Salmonella typhimurium1 µmol/plate (+enzymatic activation step)MUREAV 66,175,1979
mutation in microorganisms/Saccharomyes cerevisiae1 mmol/L (-enzymatic activation step)MUREAV 204,605,1988
mutation in microorganisms/Saccharomyes cerevisiae5 mmol/L/3HMUREAV 652,198,2008
other mutation test systemsHeLa cell/human50 µmol/LTOLED5 25,219,1985
other mutation test systemsfibroblast/human80 µmol/LMUREAV 49,305,1978
phage inhibition capacity/Escherichia coli25 µg/wellMUREAV 260,349,1991
sister chromatid exchangeleukocyte/human7900 nmol/L/19HMUREAV 57,359,1978
sister chromatid exchangelymphocyte/human7900 nmol/LBTERDG 2,81,1980
sister chromatid exchangeintraperitoneal/hamster6650 µg/kgHEREAY 93,101,1980
sister chromatid exchangelung/hamster2 mg/LCALEDQ 18,109,1983
sperm morphologyoral/rat4200 µg/kg/5W-continuousMUREAV 309,29,1994
Unscheduled DNA Synthesismammary gland/mouse50 nmol/LCNREA8 44,4361,1984
Unscheduled DNA Synthesisliver/rat100 µmol/LCALEDQ 10,75,1980
Unscheduled DNA Synthesisfibroblast/human80 µmol/L/30MMUREAV 49,305,1978

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intravenous/mouse 2836 µg/kg (12D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TOLED5 21,35,1984
oral/pig 1003 mg/kg (1-16W pregnant)Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
JANSAG 18,141,1959
oral/hamster 17290 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)REPTED 4,183,1990
oral/rat 384 mg/kg (34W male)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male
RCOCB8 58,183,1987
oral/rat 15 mg/kg (13W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)NTPTR* NIH-94-3387
oral/mouse 999 mg/kg (1-19D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
JONUAI 109,1646,1979
oral/mouse 50 mg/kg (8-12D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)JTEHD6 10,541,1982
oral/mouse 112 mg/kg (6-13D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TCMUD8 7,29,1987
oral/mouse 50 mg/kg (8-12D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)TCMUD8 4,403,1984
subcutaneous/mouse 45995 µg/kg (7-12D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)ENVRAL 19,39,1979
subcutaneous/mouse 1729 µg/kg (16D pregnant)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
INHEAO 23,95,1985
subcutaneous/mouse 7890 µg/kg (12D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NEZAAQ 36,313,1981

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intracervical/mouse lethal dose (50 percent kill): 300 µg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Dyspnea
NRTXDN 2,383,1981
intramuscular/domestic animal lethal dose (50 percent kill): 1533 µg/kgOlfaction: Other olfaction effects

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
VHTODE 29,233,1987
intramuscular/pig lowest published lethal dose: 2190 µg/kgLung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAVMA4 165,543,1974
intramuscular/rabbit lethal dose (50 percent kill): 2530 µg/kgAXVMAW 30,627,1976
intraperitoneal/rabbit lowest published lethal dose: 4 mg/kgEQSSDX 1,1,1975
intraperitoneal/rat lowest published lethal dose: 5476 µg/kgBehavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Other changes
JPETAB 58,454,1936
intravenous/Dog lethal dose (50 percent kill): 1916 µg/kgCardiac: Arrythmias (indlucing changes in conduction)

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Hypermotility, diarrhea
PSDAA2 36,173,1957
intravenous/mouse lethal dose (50 percent kill): 5 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes
NRTXDN 2,383,1981
intravenous/pig lowest published lethal dose: 6570 µg/kgBrain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Acute pulmonary edema
AJVRAH 34,1227,1973
intravenous/rabbit lowest published lethal dose: 1971 µg/kgJPETAB 33,270,1928
intravenous/rat lethal dose (50 percent kill): 3 mg/kgEQSSDX 1,1,1975
oral/cattle lowest published lethal dose: 9900 µg/kgJACTDZ 5(1),45,1986
oral/domestic animal lowest published lethal dose: 3300 µg/kgJACTDZ 5(1),45,1986
oral/guinea pig lethal dose (50 percent kill): 5060 µg/kgGISAAA 35(2),14,1970
oral/horse, donkey lethal dose (50 percent kill): 13 mg/kgCardiac: Pulse rate increased without fall in BP

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Hypermotility, diarrhea
AJVRAH 41,1925,1980
oral/man lowest published toxic dose: 24 mg/kgGastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
VHTODE 39,304,1997
oral/mouse lethal dose (50 percent kill): 7080 µg/kgGISAAA 35(2),14,1970
oral/pig lowest published lethal dose: 13 mg/kgJACTDZ 5(1),45,1986
oral/rabbit lethal dose (50 percent kill): 2250 µg/kgHYSAAV 35(1-3),176,1970
oral/rat lethal dose (50 percent kill): 7 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 20,89,1971
parenteral/chicken lethal dose (50 percent kill): 8500 µg/kgNEPHBW 25,493,1990
parenteral/rabbit lowest published lethal dose: 1971 µg/kgCTOXAO 17,171,1980
parenteral/rat lethal dose (50 percent kill): 6570 µg/kgCTOXAO 17,171,1980
subcutaneous/Dog lowest published lethal dose: 4 mg/kgEQSSDX 1,1,1975
subcutaneous/mouse lethal dose (50 percent kill): 13 mg/kgSAIGBL 17,491,1975
subcutaneous/rabbit lowest published lethal dose: 6 mg/kgBehavioral: Convulsions or effect on seizure threshold

Endocrine: Hypoglycemia
PSEBAA 24,251,1926
subcutaneous/rat lowest published toxic dose: 0.3 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductasesVCVN5* -,266,1993
subcutaneous/rat lowest published toxic dose: 0.5 mg/kgLiver: Changes in liver weightVCVN5* -,266,1993

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 61255 µg/kg/14D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: TransaminasesTXAPA9 226,251,2008
intraperitoneal/mouse lowest published toxic dose: 7627 µg/kg/7D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductasesTXAPA9 226,251,2008
oral/cattle : 67.5 mg/kg/27D- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TXCYAC 213,169,2005
oral/cattle : 22.5 mg/kg/9D- continuousBehavioral: Food intake (animal)

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Changes in structure or function of salivary glands
TXCYAC 213,169,2005
oral/cattle : 35 mg/kg/14D- continuousGastrointestinal: Decreased motility or constipationTXCYAC 213,169,2005
oral/cattle : 55 mg/kg/22D- continuousLung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXCYAC 213,169,2005
oral/duck lowest published toxic dose: 168 mg/kg/6W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Other proteins
JTEHD6 27,263,1989
oral/duck lowest published toxic dose: 58800 µg/kg/12W- continuousBlood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
AECTCV 19,836,1990
oral/mouse lowest published toxic dose: 942 mg/kg/2Y- continuousLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AEHLAU 24,66,1972
oral/mouse lowest published toxic dose: 3.85 mg/kg/7D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TXCYAC 220,179,2006
oral/pig lowest published toxic dose: 13 gm/kg/5W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
JANSAG 59,733,1984
oral/rabbit lowest published toxic dose: 2541 µg/kg/33W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 35(2),14,1970
oral/rabbit lowest published toxic dose: 45 mg/kg/50D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Interstitial nephritis
VCVN5* -,271,1989
oral/rat lowest published toxic dose: 5397 mg/kg/6W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JONUAI 104,306,1974
oral/rat lowest published toxic dose: 152 mg/kg/13W- continuousKidney, Ureter, and Bladder: Interstitial nephritis

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Effect on menstrual cycle
NTPTR* NIH-94-3387
oral/rat lowest published toxic dose: 1966 mg/kg/1Y- continuousBlood: Normocytic anemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JONUAI 10,213,1935
oral/rat lowest published toxic dose: 7439.4 µg/kg/18D- continuousBlood: Hemorrhage

Skin and Appendages: Other: Hair
TXAPA9 206,1,2005
subcutaneous/rat lowest published toxic dose: 5 mg/kg/5D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
VCVN5* -,271,1989

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 9,245,1975
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWCHREAY 28,179,1941
TOXICOLOGY REVIEWPHREA7 23,305,1943
TOXICOLOGY REVIEW85DHAX Se,112,1976
TOXICOLOGY REVIEWCRTXB2 33,305,2003

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.2 mg(Se)/m3DTLVS* 3,224,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.2 mg(Se)/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg(Se)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.2 mg(Se)/m3, MAR2002
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg(Se)/m3, short term exposure limit 0.4 mg(Se)/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 mg(Se)/m3, MAY2012
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg(Se)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.1 mg(Se)/m3, JAN1993
Occupational Exposure Limit-SWEDENtime-weighted average 0.1 mg(Se)/m3 (total dust), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.02 mg(Se)/m3, KZG-week 0.16 mg(Se)/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.2 mg(Se)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.2 mg(Se)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg(Se)/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.2 mg(Se)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.2 mg(Se)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.2 mg(Se)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.2 mg(Se)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84379; Number of Industries 7; Total Number of Facilities 741; Number of Occupations 19; Total Number of Employees Exposed 10544; Total Number of Female Employees Exposed 3736
National Occupational Hazard Survey 1974Hazard Code 84379; Number of Industries 5; Total Number of Facilities 480; Number of Occupations 5; Total Number of Employees Exposed 1198

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-human
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-human lymphocytes
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9100
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Toxicity studies, RPT# TOX-38, October 2000
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