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Selenious acid

RTECS #: VS7175000

CAS #: 7783-00-8


UPDATE: May 2009 MW: 128.98 MF: H2O3Se


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. RCRA waste number U204
  1. Selenium dioxide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis human lymphocyte 10 mol/L ESKGA2 26,99,1980
DNA damage human lymphocyte 3 mmol/L/30 minute TCMUD8 23(Suppl 2),53,2003
micronucleus test intraperitoneal
mouse
10 mg/kg/2 day- continuous MUREAV 367,233,1996


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published lethal dose: 10 mg/kg N/R NCNSA6 5,28,1953
intravenous
mouse
lethal dose (50 percent kill): 11 mg/kg N/R CSLNX* NX#05656
oral
rat
lowest published lethal dose: 25 mg/kg N/R NCNSA6 5,28,1953
skin
rabbit
lethal dose (50 percent kill): 4 mg/kg N/R ENTOX* ,774,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 39,210 g/kg/8 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 226,251,2008
intraperitoneal
rat
lowest published toxic dose: 0.938 mg/kg/14 day- intermittent Blood: Changes in bone marrow not included in above

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
JTEHD6 59,553,2000
subcutaneous
rabbit
lowest published toxic dose: 4,800 g/kg/14 day- intermittent Behavioral: Food intake (animal)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NEZAAQ 14,9,1959


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg(Se)/m3 DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 627,10,2007
TOXICOLOGY REVIEW
ENTOX* -,774,2005
TOXICOLOGY REVIEW
HBTME* ,783,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.2 mg(Se)/m3 DTLVS* 3,224,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.2 mg(Se)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.2 mg(Se)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.2 mg(Se)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.2 mg(Se)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.2 mg(Se)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg(Se)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg(Se)/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg(Se)/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg(Se)/m3, short term exposure limit 0.3 mg(Se)/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.05 mg(Se)/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg(Se)/m3, short term exposure limit 0.4 mg(Se)/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 mg(Se)/m3, APR2007
Occupational Exposure Limit - MEXICO time-weighted average 0.2 mg(Se)/m3, 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg(Se)/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg(Se)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.2 mg(Se)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.1 mg(Se)/m3, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 0.1 mg(Se)/m3 (total dust), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 mg(Se)/m3,KZG- week 0.2 mg(Se)/m3, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 0.2 mg(Se)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg(Se)/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.2 mg(Se)/m3
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.2 mg(Se)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84466;
Number of Industries 4;
Total Number of Facilities 345;
Number of Occupations 3;
Total Number of Employees Exposed 1,177
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84466;
Number of Industries 17;
Total Number of Facilities 1,294;
Number of Occupations 17;
Total Number of Employees Exposed 7,593;
Total Number of Female Employees Exposed 1,866


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as oxidizing agent
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ESKGA2 Eisei Kagaku. Hygienic Chemistry. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1953-
HBTME*
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC)
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as oxidizing agent

NIOSH PROFILE (SELENIUM AND ITS COMPOUND), SRC, 4/78

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Human Data

ALT CAS #: 11140-60-6
Click Here for Additional Information about RTECS

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