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Registry of Toxic Effects of Chemical Substances (RTECS)

Selenious acid

RTECS #

VS7175000

CAS #

7783-00-8; 11140-60-6

Updated

July 2013

Molecular Weight

128.98

Molecular Formula

H2O3Se

Synonyms

RCRA waste number U204
Selenium dioxide

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human10 µmol/LESKGA2 26,99,1980
DNA Damagelymphocyte/human3 mmol/L/30MTCMUD8 23(Suppl 2),53,2003
micronucleus testintraperitoneal/mouse10 mg/kg/2D-continuousMUREAV 367,233,1996

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published lethal dose: 10 mg/kgNCNSA6 5,28,1953
intravenous/mouse lethal dose (50 percent kill): 11 mg/kgCSLNX* NX#05656
oral/rat lowest published lethal dose: 25 mg/kgNCNSA6 5,28,1953
skin/rabbit lethal dose (50 percent kill): 4 mg/kgENTOX* ,774,2005

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 39210 µg/kg/8D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 226,251,2008
intraperitoneal/rat lowest published toxic dose: 0.938 mg/kg/14D- intermittentBlood: Changes in bone marrow not included in above

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
JTEHD6 59,553,2000
subcutaneous/rabbit lowest published toxic dose: 4800 µg/kg/14D- intermittentBehavioral: Food intake (animal)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NEZAAQ 14,9,1959

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 627,10,2007
TOXICOLOGY REVIEWENTOX* -,774,2005
TOXICOLOGY REVIEWHBTME* ,783,2007
TOXICOLOGY REVIEWMUTAEX 23,153,2008
TOXICOLOGY REVIEWMUREAV 26,253,2011
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.2 mg(Se)/m3DTLVS* 3,224,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.2 mg(Se)/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg(Se)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.2 mg(Se)/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 mg(Se)/m3, MAY2011
Occupational Exposure Limit-GERMANYMAK 0.02 mg(Se)/m3, inhal, skin, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg(Se)/m3, short term exposure limit 0.4 mg(Se)/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 mg(Se)/m3, MAY2012
Occupational Exposure Limit-MEXICOtime-weighted average 0.2 mg(Se)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg(Se)/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg(Se)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.1 mg(Se)/m3, JAN1993
Occupational Exposure Limit-SWEDENtime-weighted average 0.1 mg(Se)/m3 (total dust), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.02 mg(Se)/m3, KZG-week 0.16 mg(Se)/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.2 mg(Se)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.2 mg(Se)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg(Se)/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.2 mg(Se)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.2 mg(Se)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.2 mg(Se)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.2 mg(Se)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84466; Number of Industries 17; Total Number of Facilities 1294; Number of Occupations 17; Total Number of Employees Exposed 7593; Total Number of Female Employees Exposed 1866
National Occupational Hazard Survey 1974Hazard Code 84466; Number of Industries 4; Total Number of Facilities 345; Number of Occupations 3; Total Number of Employees Exposed 1177

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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