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Sebacic acid, dibutyl ester

RTECS #: VS1150000

CAS #: 109-43-3


UPDATE: February 2006 MW: 314.52 MF: C18H34O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Bis (n - butyl) sebacate
  2. Decanedioic acid, dibutyl ester
  3. Di - n - butyl sebacate
  4. Dibutylester kyseliny sebakove (Czech)
  5. Dibutyl sebacate
  1. Kodaflex DBS
  2. Monoplex DBS
  3. PX 404
  4. Polycizer DBS
  5. Staflex DBS


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 418 gm/kg (10 week male/10 day prior to copulation) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) AMIHBC 7,310,1953


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration : >5,400 g/m3/2 hour N/R GISAAA 55(6),86,1990
inhalation
rat
lethal concentration : >5,400 g/m3/4 hour N/R GISAAA 55(6),86,1990
intraperitoneal
mouse
lethal dose (50 percent kill): 14,700 L/kg N/R JBMRBG 8,11,1974
oral
mouse
lethal dose (50 percent kill): 19,500 mg/kg Lung, Thorax, or Respiration: Other changes GISAAA 55(6),86,1990
oral
rat
lethal dose (50 percent kill): 14,870 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Liver: Liver function tests impaired
STGNBT -,69,1999


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 66 gm/kg/30 day- intermittent Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
STGNBT -,69,1999
unreported route
rabbit
lowest published toxic dose: 50,400 mg/kg/12 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
STGNBT -,69,1999


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84499;
Number of Industries 4;
Total Number of Facilities 67;
Number of Occupations 10;
Total Number of Employees Exposed 2,492
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84499;
Number of Industries 4;
Total Number of Facilities 400;
Number of Occupations 5;
Total Number of Employees Exposed 4,856;
Total Number of Female Employees Exposed 2,157


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an agent in production of food packing materials
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JBMRBG Journal of Biomedical Materials Research. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1- 1967-
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999

Used as an agent in production of food packing materials

RTECS Compound Description:
   Reproductive Effector

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