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Registry of Toxic Effects of Chemical Substances (RTECS)

Sebacic acid, dibutyl ester

RTECS #

VS1150000

CAS #

109-43-3

Updated

February 2006

Molecular Weight

314.52

Molecular Formula

C18H34O4

Synonyms

Bis(n-butyl)sebacate
Decanedioic acid, dibutyl ester
Dibutyl sebacate
Dibutylester kyseliny sebakove (Czech)
Di-n-butyl sebacate
Kodaflex DBS
Monoplex DBS
Polycizer DBS
PX 404
Staflex DBS

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 418 gm/kg (10W male/10D prior to copulation)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)AMIHBC 7,310,1953

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lethal concentration: >5400 µg/m3/2HGISAAA 55(6),86,1990
inhalation/rat Lethal concentration: >5400 µg/m3/4HGISAAA 55(6),86,1990
intraperitoneal/mouse lethal dose (50 percent kill): 14700 µL/kgJBMRBG 8,11,1974
oral/mouse lethal dose (50 percent kill): 19500 mg/kgLung, Thorax, or Respiration: Other changesGISAAA 55(6),86,1990
oral/rat lethal dose (50 percent kill): 14870 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Liver: Liver function tests impaired
STGNBT -,69,1999

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 66 gm/kg/30D- intermittentBlood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
STGNBT -,69,1999
unreported route/rabbit lowest published toxic dose: 50400 mg/kg/12W- intermittentBlood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
STGNBT -,69,1999

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84499; Number of Industries 4; Total Number of Facilities 400; Number of Occupations 5; Total Number of Employees Exposed 4856; Total Number of Female Employees Exposed 2157
National Occupational Hazard Survey 1974Hazard Code 84499; Number of Industries 4; Total Number of Facilities 67; Number of Occupations 10; Total Number of Employees Exposed 2492

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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