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Registry of Toxic Effects of Chemical Substances (RTECS)

Salicylic acid

RTECS #

VO0525000

CAS #

69-72-7

Updated

December 2013

Molecular Weight

138.13

Molecular Formula

C7H6O3

Synonyms

2-Hydroxybenzoic acid
Acido o-idrossibenzoico (Italian)
Acido salicilico (Italian)
Benzoic acid, 2-hydroxy-
Keralyt
Kyselina 2-hydroxybenzoova (Czech)
Kyselina salicylova (Czech)
o-Hydroxybenzoic acid
Orthohydroxybenzoic acid
Retarder W
SA
SAX
Verrugon

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionoral/mouse100 mg/kgMUREAV 46,305,1977
DNA repair/Bacillus subtilis5 mg/discJNUDAT 34,183,1992
mutation in microorganisms/Saccharomyes cerevisiae1 mmol/L/3H (-enzymatic activation step)MUREAV 60,291,1979
mutation in microorganisms/Bacillus subtilis5 mg/disc/48HHPV141 -,-,2001
mutation in microorganisms/Salmonella typhimurium100 µg/disc (+enzymatic activation step)JNUDAT 34,183,1992

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 40 mg/kg (20-21D pregnant)Reproductive: Maternal effects: ParturitionPRGLBA 4,93,1973
oral/rat 1050 mg/kg (8-14D pregnant)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
SEIJBO 13,73,1973
oral/rat 1050 mg/kg (8-14D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
SEIJBO 13,73,1973
oral/rat 700 mg/kg (8-14D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
SKEZAP 14,549,1973
oral/rat 350 mg/kg (8-14D pregnant)Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)SKEZAP 14,549,1973
oral/mouse 1 gm/kg (17D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
APTOA6 35,107,1974
oral/mouse 500 mg/kg (9D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemAPTOA6 35,107,1974
subcutaneous/rat 380 mg/kg (9D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities
BCPCA6 22,407,1973

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, monocyte Inhibitor Concentration Low: 500 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TXAPA9 245,211,2010
In Vitro/Rat, liver Inhibitor Concentration Low: 5 mmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Other assays
TXAPA9 249,140,2010
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): >300 mg/m3GISAAA 57(7-8),31,1992
intraperitoneal/mouse lethal dose (50 percent kill): 300 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
GNRIDX 3,675,1969
intraperitoneal/rat lethal dose (50 percent kill): 157 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Nutritional and Gross Metabolic: Body temperature decrease
GISAAA 57(7-8),31,1992
intravenous/mouse lethal dose (50 percent kill): 184 mg/kgBehavioral: Convulsions or effect on seizure thresholdYKKZAJ 91,550,1971
oral/cat lethal dose (50 percent kill): 400 mg/kgHBTXAC 5,148,1959
oral/mouse lethal dose (50 percent kill): 480 mg/kgHBTXAC 5,148,1959
oral/rabbit lethal dose (50 percent kill): 1300 mg/kgNIIRDN 6,291,1982
skin/man lowest published toxic dose: 57 mg/kgEar: TinnitusJAMAAP 244,660,1980
skin/rat lethal dose (50 percent kill): >2 gm/kgLiver: Other changes

Skin and Appendages: Other: Hair
ATDAEI 15(Suppl 1),S81,1996
skin/woman lowest published toxic dose: 111 mg/kg/10D- intermittentEar: Change in acuity

Cardiac: Pulse rate increased without fall in BP

Nutritional and Gross Metabolic: Body temperature increase
PGMJAO 70,146,1994
subcutaneous/mouse lethal dose (60 percent kill): 520 mg/kgCardiac: Change in rate

Behavioral: Muscle weakness
AIPTAK 38,9,1930
subcutaneous/rabbit lowest published lethal dose: 6 gm/kgHBAMAK 4,1392,1935

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWAIPTAK 34,173,1928
TOXICOLOGY REVIEWTOLED5 144,383,2003
TOXICOLOGY REVIEWJEADV* 13,14,1999
TOXICOLOGY REVIEWTPHSDY 24,331,2003
TOXICOLOGY REVIEWAINCM* 7,63,2006
TOXICOLOGY REVIEWIJTOFN 22,1,2003
TOXICOLOGY REVIEWNBREV* 11,35,1987
TOXICOLOGY REVIEWTXAPA9 243,239,2010
TOXICOLOGY REVIEWFCLPH* 22,335,2008
TOXICOLOGY REVIEWFCTOD7 50,2243,2012

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,334,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 67680; Number of Industries 40; Total Number of Facilities 2133; Number of Occupations 50; Total Number of Employees Exposed 51922; Total Number of Female Employees Exposed 20096
National Occupational Hazard Survey 1974Hazard Code 67680; Number of Industries 39; Total Number of Facilities 6955; Number of Occupations 57; Total Number of Employees Exposed 61410

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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