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Registry of Toxic Effects of Chemical Substances (RTECS)

Salicylic acid, methyl ester

RTECS #

VO4725000

CAS #

119-36-8

Updated

December 2013

Molecular Weight

152.16

Molecular Formula

C8H8O3

Synonyms

2-Hydroxybenzoic acid methyl ester
Benzoic acid, 2-hydroxy-, methyl ester
Betula
Betula oil
Exagien
Flucarmit
Gaultheria oil
Gaultheria oil, artificial
Methyl o-hydroxybenzoate
Methyl salicylate
Methylester kyseliny salicylove (Czech)
Natural wintergreen oil
o-Anisic acid
o-Hydroxybenzoic acid, methyl ester
Oil of wintergreen
Synthetic wintergreen oil
Teaberry oil
Wintergreen oil
Wintergreen oil, synthetic

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /guinea pig 100% severeFCTXAV 16,821,1978
eye /rabbit 500 mg/24H mild85JCAE -,668,1986
skin /guinea pig 100% severeFCTXAV 16,821,1978
skin /rabbit 500 mg/24H moderateFCTXAV 16,821,1978

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium100 µg/disc (+enzymatic activation step)JNUDAT 34,183,1992
mutation in microorganisms/Salmonella typhimurium0.1 mg/disc/48H (+enzymatic activation step)HPV141 -,-,2001

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 400 mg/kg (12D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)FAATDF 11,381,1988
intraperitoneal/rat 500 mg/kg (11-12D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Urogenital system
FAATDF 11,381,1988
oral/hamster 1750 mg/kg (7D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemTJADAB 28,421,1983
oral/rat 36450 mg/kg (multigenerations)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TXAPA9 18,755,1971
skin/hamster 5250 mg/kg (7D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemTJADAB 28,421,1983
subcutaneous/rat 500 mg/kg (10D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Central nervous system
AJPAA4 35,315,1959
subcutaneous/rat 500 mg/kg (10D pregnant)Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
AJPAA4 35,315,1959

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 18 mg/m3Behavioral: Change in psychophysiological testsGISAAA 1,4,1994
oral/child lowest published lethal dose: 228 mg/kgLung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Nausea or vomiting
AJDCAI 69,37,1945
oral/child lowest published lethal dose: 700 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: General anesthetic

Lung, Thorax, or Respiration: Dyspnea
ADCHAK 28,475,1953
oral/Dog lethal dose (50 percent kill): 2100 mg/kgLung, Thorax, or Respiration: Other changes

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
FCTXAV 16,821,1978
oral/guinea pig lethal dose (50 percent kill): 700 mg/kg14CYAT 2,1897,1963
oral/human lowest published lethal dose: 506 mg/kg85KYAH 11,961,1989
oral/infant lowest published lethal dose: 1480 mg/kgLung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Nausea or vomiting
AJMSA9 193,772,1937
oral/man lowest published lethal dose: 101 mg/kgBehavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting
AJMSA9 193,772,1937
oral/man lowest published lethal dose: 1329 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Blood: Hemorrhage
CTOXAO 6,189,1973
oral/mouse lethal dose (50 percent kill): 1110 mg/kgJPETAB 132,207,1961
oral/rabbit lethal dose (50 percent kill): 1300 mg/kgFCTXAV 16,821,1978
oral/rat lowest published toxic dose: 122 mg/kgBehavioral: Change in psychophysiological tests

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 1,4,1994
oral/rat lethal dose (50 percent kill): 887 mg/kgBehavioral: Somnolence (general depressed activity)FCTXAV 2,327,1964
oral/rat lethal dose (50 percent kill): 887 mg/kgHPV141 -,-,2001
oral/rat lethal dose (50 percent kill): 2823 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Gastritis
HPV141 -,-,2001
oral/woman lowest published lethal dose: 355 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Nausea or vomiting
AJMSA9 193,772,1937
skin/rat lowest published toxic dose: 240 mg/kgBehavioral: AnalgesiaFTRPAE 75,123,2004
subcutaneous/Dog lowest published lethal dose: 2250 mg/kgFCTXAV 16,821,1978
subcutaneous/guinea pig lowest published lethal dose: 1500 mg/kgFAONAU 44A,63,1967
subcutaneous/rabbit lowest published lethal dose: 4250 mg/kgFCTXAV 16,821,1978
unreported route/man lowest published lethal dose: 522 mg/kg85DCAI 2,73,1970

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 40 mg/m3/4W- intermittentImmunological Including Allergic: Anaphylaxis (multiple organ involvement)GISAAA 1,4,1994
inhalation/mouse lowest published toxic concentration: 40 mg/m3/4W- intermittentImmunological Including Allergic: Decreased immune responseGISAAA 1,4,1994
inhalation/rat lowest published toxic concentration: 8 mg/m3/4H/16W- intermittentBehavioral: Change in psychophysiological tests

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases
GISAAA 1,4,1994
inhalation/rat lowest published toxic concentration: 40 mg/m3/4H/17W- intermittentBlood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
GISAAA 57(7-8),28,1992
oral/Dog lowest published toxic dose: 40800 mg/kg/59D- intermittentLiver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 5,576,1963
oral/Dog lowest published toxic dose: 93600 mg/kg/2Y- intermittentLiver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 5,576,1963
oral/Dog lowest published toxic dose: 35 gm/kg/10W- intermittentLiver: Fatty liver degenerationFAONAU 44A,1,1967
oral/Dog lowest published toxic dose: 24000 mg/kg/59D- intermittentGastrointestinal: Hypermotility, diarrheaHPV141 -,-,2001
oral/Dog lowest published toxic dose: 38400 mg/kg/59D- intermittentGastrointestinal: Hypermotility, diarrhea

Liver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV141 -,-,2001
oral/Dog lowest published toxic dose: 109500 mg/kg/2Y- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV141 -,-,2001
oral/Dog lowest published toxic dose: 112500 mg/kg/225D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV141 -,-,2001
oral/rat lowest published toxic dose: 85200 mg/kg/10W- continuousMusculoskeletal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 5,576,1963
oral/rat lowest published toxic dose: 71400 mg/kg/17W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainTXAPA9 5,576,1963
oral/rat lowest published toxic dose: 546 gm/kg/2Y- continuousCardiac: Changes in heart weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 5,576,1963
oral/rat lowest published toxic dose: 59500 mg/kg/17W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV141 -,-,2001
oral/rat lowest published toxic dose: 730000 mg/kg/2Y- intermittentMusculoskeletal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV141 -,-,2001
oral/rat lowest published toxic dose: 71000 mg/kg/71D- intermittentGastrointestinal: Ulceration or bleeding from stomach

Musculoskeletal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV141 -,-,2001
oral/rat lowest published toxic dose: 118650 mg/kg/30W- intermittentBehavioral: Food intake (animal)

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV141 -,-,2001
oral/rat lowest published toxic dose: 77000 mg/kg/11W- intermittentMusculoskeletal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV141 -,-,2001
oral/rat lowest published toxic dose: 42000 mg/kg/6W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV141 -,-,2001
skin/mouse lowest published toxic dose: 25 pph/3D- intermittentImmunological Including Allergic: Increase in cellular immune responseTXCYAC 261,103,2009
skin/rabbit lowest published toxic dose: 40 mL/kg/28D- intermittentSkin: After systemic exposure: Dermatitis, otherHPV141 -,-,2001
skin/rabbit lowest published toxic dose: 80 mL/kg/28D- intermittentSkin: After systemic exposure: Dermatitis, other

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV141 -,-,2001
skin/rabbit lowest published toxic dose: 330 gm/kg/90D- intermittentGastrointestinal: Changes in structure or function of exocrine pancreas

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 5,576,1963
skin/rat lowest published toxic dose: 281.1 mg/kg/3D- intermittentKidney, Ureter, and Bladder: Changes in kidney weightTXCYAC 117,229,1997

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWDICPBB 9,350,1975
TOXICOLOGY REVIEWCLCHAU 19,361,1973
TOXICOLOGY REVIEWARVPAX 5,447,1965
TOXICOLOGY REVIEWAJMEAZ 38,409,1965
TOXICOLOGY REVIEWEVHPAZ 15,121,1976
TOXICOLOGY REVIEWFAATDF 13,747,1989
TOXICOLOGY REVIEWTOLED5 140-141,239,2003
TOXICOLOGY REVIEWIJPOL* 58,229,2001
TOXICOLOGY REVIEWJEMME* 32,63,2007
TOXICOLOGY REVIEWIJTOFN 22,1,2003
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWNBREV* 11,35,1987
TOXICOLOGY REVIEWJOETD7 138,212,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,334,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 48320; Number of Industries 193; Total Number of Facilities 30724; Number of Occupations 134; Total Number of Employees Exposed 454822; Total Number of Female Employees Exposed 134722
National Occupational Hazard Survey 1974Hazard Code 48320; Number of Industries 138; Total Number of Facilities 15668; Number of Occupations 80; Total Number of Employees Exposed 105490

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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