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Riboflavine

RTECS #: VJ1400000

CAS #: 83-88-5

UPDATE: May 2009 MW: 376.41 MF: C17H20N4O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 6,7 - Dimethyl - 9 - D - ribitylisoalloxazine
  2. Beflavine
  3. Flavaxin
  4. Flaxain
  5. HYRE
  6. Hyflavin
  7. Isoalloxazine, 7,8 - dimethyl - 10 - D - ribityl -
  8. Isoalloxazine, 7,8 - dimethyl - 10 - (D - ribo - 2,3,4,5 - tetrahydroxypentyl) -
  1. Lactoflavin
  2. Lactoflavine
  3. Ribipca
  4. Riboderm
  5. Riboflavin
  6. Riboflavinequinone
  7. Vitamin B2
  8. Vitamin G


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 300 mg/L GMCRDC 27,95,1981
mutation in microorganisms Salmonella typhimurium 500 µg/plate (-enzymatic activation step) TRENAF 37,447,1986
sex chromosome loss and nondisjunction hamster lung 100 mg/L MUREAV 373,1,1997


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 50 mg/kg Behavioral: Analgesia EJPHAZ 547,184,2006
intraperitoneal
rat 		lethal dose (50 percent kill): 560 mg/kg Behavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JPETAB 76,75,1942
intraperitoneal
rat 		lowest published toxic dose: 25 mg/kg Behavioral: Analgesia EJPHAZ 547,184,2006
intraperitoneal
rat 		lowest published toxic dose: 50 mg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation EJPHAZ 547,184,2006
intravenous
rat 		lethal dose (50 percent kill): 50 mg/kg N/R FAONAU 46A,20,1969
oral
dog 		lethal dose : >2 gm/kg N/R JPETAB 76,75,1942
oral
rat 		lethal dose (50 percent kill): >10 gm/kg N/R JPETAB 76,75,1942
subcutaneous
rat 		lethal dose (50 percent kill): 5 gm/kg N/R JPETAB 76,75,1942


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
ENTOX* -,701,2005
TOXICOLOGY REVIEW
HTOPA* 1,595,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 67410;
Number of Industries 8;
Total Number of Facilities 1,890;
Number of Occupations 22;
Total Number of Employees Exposed 24,319
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 67410;
Number of Industries 15;
Total Number of Facilities 2,923;
Number of Occupations 45;
Total Number of Employees Exposed 74,790;
Total Number of Female Employees Exposed 35,023


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971-
HTOPA*
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1- 1949/50-

Used as vitamin

RTECS Compound Description:
   Drug
   Mutagen

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