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Registry of Toxic Effects of Chemical Substances (RTECS)

Riboflavine

RTECS #

VJ1400000

CAS #

83-88-5

Updated

October 2011

Molecular Weight

376.41

Molecular Formula

C17H20N4O6

Synonyms

6,7-Dimethyl-9-D-ribitylisoalloxazine
Beflavine
Flavaxin
Flaxain
Hyflavin
HYRE
Isoalloxazine, 7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-
Isoalloxazine, 7,8-dimethyl-10-D-ribityl-
Lactoflavin
Lactoflavine
Ribipca
Riboderm
Riboflavin
Riboflavinequinone
Vitamin B2
Vitamin G

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster300 mg/LGMCRDC 27,95,1981
mutation in microorganisms/Salmonella typhimurium500 µg/plate (-enzymatic activation step)TRENAF 37,447,1986
sex chromosome loss and nondisjunctionlung/hamster100 mg/LMUREAV 373,1,1997

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 50 mg/kgBehavioral: AnalgesiaEJPHAZ 547,184,2006
intraperitoneal/rat lowest published toxic dose: 25 mg/kgBehavioral: AnalgesiaEJPHAZ 547,184,2006
intraperitoneal/rat lowest published toxic dose: 50 mg/kgBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationEJPHAZ 547,184,2006
intraperitoneal/rat lethal dose (50 percent kill): 560 mg/kgBehavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JPETAB 76,75,1942
intravenous/rat lethal dose (50 percent kill): 50 mg/kgFAONAU 46A,20,1969
oral/Dog Lethal dose: >2 gm/kgJPETAB 76,75,1942
oral/rat lethal dose (50 percent kill): >10 gm/kgJPETAB 76,75,1942
subcutaneous/rat lethal dose (50 percent kill): 5 gm/kgJPETAB 76,75,1942

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 16 mg/kg/30D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
FCTOD7 48,2052,2010

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWENTOX* -,701,2005
TOXICOLOGY REVIEWHTOPA* 1,595,2002

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 67410; Number of Industries 15; Total Number of Facilities 2923; Number of Occupations 45; Total Number of Employees Exposed 74790; Total Number of Female Employees Exposed 35023
National Occupational Hazard Survey 1974Hazard Code 67410; Number of Industries 8; Total Number of Facilities 1890; Number of Occupations 22; Total Number of Employees Exposed 24319

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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