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Registry of Toxic Effects of Chemical Substances (RTECS)

Resorcinol, diglycidyl-

RTECS #

VH1050000

CAS #

101-90-6

Updated

July 2013

Molecular Weight

222.26

Molecular Formula

C12H14O4

Synonyms

1,3-Bis(2,3-epoxypropoxy)benzene
1,3-Diglycidyloxybenzene
2,2'-(1,3-Phenylenebis(oxymethylene))bisoxirane
Araldite ERE 1359
Diglycidyl ether of resorcinol
Diglycidyl resorcinol ether
ERE 1359
m-Bis(2,3-epoxypropoxy)benzene
meta-Bis(glycidyloxy)benzene
NCI-C54966
Oxirane, 2,2'-(1,3-phenylenebis(oxymethylene))bis-
RDGE
Resorcinol bis(2,3-epoxypropyl)ether
Resorcinol diglycidyl ether
Resorcinyl diglycidyl ether

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg/24H moderateAMIHAB 17,129,1958

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster8 mg/LMUREAV 135,159,1984
heritable translocation testoral/Drosophila melanogaster5 pphENMUDM 7,325,1985
mutation in mammalian somatic cellslymphocyte/mouse100 µg/LSCIEAS 236,933,1987
mutation in microorganisms/Salmonella typhimurium33 µg/plate (+/-enzymatic activation step)MUREAV 172,105,1986
mutation in microorganisms/Salmonella typhimurium50 mg/L/2H (-enzymatic activation step)EMMUEG 44,329,2004
mutation in microorganisms/Salmonella typhimurium200 mg/L/2H (+enzymatic activation step)EMMUEG 44,329,2004
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster5 pphENMUDM 7,325,1985
sister chromatid exchangeovary/hamster50 µg/LSCIEAS 236,933,1987

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse toxic dose: 51500 mg/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease
NTPTR* NTP-TR-257,1986
oral/mouse toxic dose: 25750 mg/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
FCTOD7 28,723,1990
oral/mouse lowest published toxic dose: 25750 mg/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NTPTR* NTP-TR-257,1986
oral/mouse lowest published toxic dose: 25750 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB87-146734/AS
oral/rat lowest published toxic dose: 6180 mg/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NTPTR* NTP-TR-257,1986
oral/rat toxic dose: 12875 mg/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
FCTOD7 28,723,1990
oral/rat lowest published toxic dose: 12875 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB87-146734/AS
unreported route/mouse lowest published toxic dose: 6700 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
RARSAM 3,193,1963

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 243 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Peritonitis
AMIHAB 17,129,1958
intraperitoneal/mouse lethal dose (50 percent kill): 0.243 gm/kgSkin: After topical application: Primary irritationTPKVAL 2,12,1961
intraperitoneal/rat lethal dose (50 percent kill): 178 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Peritonitis
AMIHAB 17,129,1958
intraperitoneal/rat lethal dose (50 percent kill): 0.178 gm/kgTPKVAL 2,12,1961
ocular/rabbit lowest published toxic dose: 20 pphEye: Conjunctiva irritationTPKVAL 2,12,1961
oral/mouse lethal dose (50 percent kill): 0.98 gm/kgTPKVAL 2,12,1961
oral/mouse lethal dose (50 percent kill): 980 mg/kgBehavioral: Somnolence (general depressed activity)AMIHAB 17,129,1958
oral/rabbit lethal dose (50 percent kill): 1240 mg/kgBehavioral: Somnolence (general depressed activity)AMIHAB 17,129,1958
oral/rabbit lethal dose (50 percent kill): 1.24 gm/kgTPKVAL 2,12,1961
oral/rat lethal dose (50 percent kill): 2570 mg/kgGastrointestinal: Ulceration or bleeding from duodeumAMIHAB 17,129,1958
oral/rat lethal dose (50 percent kill): 2.57 gm/kgTPKVAL 2,12,1961

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 10500 mg/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-257,1986
oral/mouse lowest published toxic dose: 26 gm/kg/13W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-257,1986
oral/rat lowest published toxic dose: 5320 mg/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-257,1986
oral/rat lowest published toxic dose: 13 gm/kg/13W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-257,1986

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 36,181,1985
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 71,1417,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 36,181,1985
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1417,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 71,1417,1999
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 654,114,2008

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-SWITZERLANDcarc 2, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83725; Number of Industries 5; Total Number of Facilities 28; Number of Occupations 7; Total Number of Employees Exposed 1856; Total Number of Female Employees Exposed 222
National Occupational Hazard Survey 1974Hazard Code 83725; Number of Industries 4; Total Number of Facilities 193; Number of Occupations 8; Total Number of Employees Exposed 2994

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NIOSH CURRENT INTELLIGENCE BULLETIN 29, 1978
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
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