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8 - Quinolinol, copper (II) chelate

RTECS #: VC5250000

CAS #: 10380-28-6


UPDATE: May 2009 MW: 351.86 MF: C18H12CuN2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 8 - Hydroxyquinoline copper complex
  2. Bioquin 1
  3. Bis (8 - oxyquinoline) copper
  4. Bis (8 - quinolinato) copper
  5. Bis (8 - quinolinolato) copper
  6. Bis (quinolin - 8 - olato) copper (IUPAC)
  7. Cellu - quin
  8. Copper 8 - hydroxyquinolate
  9. Copper hydroxyquinolinate
  10. Copper 8 - hydroxyquinolinate
  11. Copper 8 - hydroxyquinoline
  12. Copper oxinate
  13. Copper (2+) oxinate
  14. Copper oxine
  15. Copper oxyquinolate
  16. Copper oxyquinoline
  17. Copper quinolate
  18. Copper 8 - quinolate
  1. Copper 8 - quinolinol
  2. Copper quinolinolate
  3. Copper 8 - quinolinolate
  4. Copper, bis (8 - quinolinolato - N (sup 1) ,O (sup 8) ) -
  5. Copper - 8
  6. Cunilate
  7. Cunilate 2472
  8. Cupric 8 - hydroxyquinolate
  9. Cupric 8 - quinolinolate
  10. Dokirin
  11. Fruitdo
  12. Milmer
  13. Oxime copper
  14. Oxine copper
  15. Oxine cuivre
  16. Oxyquinolinoleate de cuivre (French)
  17. Quinondo


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 5 g/plate (-enzymatic activation step) MUREAV 116,185,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
subcutaneous
mouse
lowest published toxic dose: 156 mg/kg/39 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
JNCIAM 24,109,1960


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 820 mg/m3 N/R NNGADV 16,563,1991
intraperitoneal
mouse
lethal dose (50 percent kill): 67 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
TXAPA9 5,599,1963
intraperitoneal
rat
lethal dose (50 percent kill): 22 mg/kg N/R NNGADV 16,563,1991
oral
mouse
lethal dose (50 percent kill): 3,940 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea
GISAAA 51(1),85,1986
oral
rat
lethal dose (50 percent kill): 9,930 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea
GISAAA 51(1),85,1986
skin
rabbit
lethal dose (50 percent kill): >2 gm/kg N/R NNGADV 16,563,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 54,600 mg/kg/2 year- continuous Gastrointestinal: Malabsorption

Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Change in gall bladder structure or function
NNGADV 16,563,1991
oral
mouse
lowest published toxic dose: 21,840 mg/kg/13 week- continuous Liver: Other changes

Endocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NNGADV 16,563,1991
oral
rat
lowest published toxic dose: 48 gm/kg/30 day- intermittent Liver: Liver function tests impaired

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GISAAA 51(1),86,1986
oral
rat
lowest published toxic dose: 87,600 mg/kg/2 year- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Endocrine: Changes in spleen weight
NNGADV 16,563,1991


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 15,103,1977
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 15,103,1977
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
HUTOX* -,561,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,303,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82785;
Number of Industries 3;
Total Number of Facilities 28;
Number of Occupations 7;
Total Number of Employees Exposed 792
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 82785;
Number of Industries 3;
Total Number of Facilities 33;
Number of Occupations 3;
Total Number of Employees Exposed 406


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as fungicide to prevent mold growth, control fungus disease in agriculture
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HUTOX*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as fungicide to prevent mold growth, control fungus disease in agriculture

NIOSH PROFILE (COPPER and COMPOUNDS), SRC, 3/82

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen

Click Here for Additional Information about RTECS

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