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Registry of Toxic Effects of Chemical Substances (RTECS)

8-Quinolinol, copper (II) chelate

RTECS #

VC5250000

CAS #

10380-28-6

Updated

April 2012

Molecular Weight

351.86

Molecular Formula

C18H12CuN2O2

Synonyms

8-Hydroxyquinoline copper complex
Bioquin 1
Bis(8-oxyquinoline)copper
Bis(8-quinolinato)copper
Bis(8-quinolinolato)copper
Bis(quinolin-8-olato)copper (IUPAC)
Cellu-quin
Copper (2+) oxinate
Copper 8-hydroxyquinolate
Copper 8-hydroxyquinolinate
Copper 8-hydroxyquinoline
Copper 8-quinolate
Copper 8-quinolinol
Copper 8-quinolinolate
Copper hydroxyquinolinate
Copper oxinate
Copper oxine
Copper oxyquinolate
Copper oxyquinoline
Copper quinolate
Copper quinolinolate
Copper, bis(8-quinolinolato-N(sup 1),O(sup 8))-
Copper-8
Cunilate
Cunilate 2472
Cupric 8-hydroxyquinolate
Cupric 8-quinolinolate
Dokirin
Fruitdo
Milmer
Oxime copper
Oxine copper
Oxine cuivre
Oxyquinolinoleate de cuivre (French)
Quinondo

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium5 µg/plate (-enzymatic activation step)MUREAV 116,185,1983

Tumorigenic Data and References

Route/OrganismDoseEffectReference
subcutaneous/mouse lowest published toxic dose: 156 mg/kg/39W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
JNCIAM 24,109,1960

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 820 mg/m3NNGADV 16,563,1991
intraperitoneal/mouse lethal dose (50 percent kill): 67 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
TXAPA9 5,599,1963
intraperitoneal/rat lethal dose (50 percent kill): 22 mg/kgNNGADV 16,563,1991
oral/mouse lethal dose (50 percent kill): 3940 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea
GISAAA 51(1),85,1986
oral/rat lethal dose (50 percent kill): 9930 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea
GISAAA 51(1),85,1986
skin/rabbit lethal dose (50 percent kill): >2 gm/kgNNGADV 16,563,1991

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 54600 mg/kg/2Y- continuousGastrointestinal: Malabsorption

Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Change in gall bladder structure or function
NNGADV 16,563,1991
oral/mouse lowest published toxic dose: 21840 mg/kg/13W- continuousLiver: Other changes

Endocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NNGADV 16,563,1991
oral/rat lowest published toxic dose: 48 gm/kg/30D- intermittentLiver: Liver function tests impaired

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GISAAA 51(1),86,1986
oral/rat lowest published toxic dose: 87600 mg/kg/2Y- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Endocrine: Changes in spleen weight
NNGADV 16,563,1991

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 15,103,1977
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 15,103,1977
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWHUTOX* -,561,1996

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,303,1998
Occupational Exposure Limit-FINLANDtime-weighted average 1 mg(Cu)/m3, NOV2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 82785; Number of Industries 3; Total Number of Facilities 33; Number of Occupations 3; Total Number of Employees Exposed 406
National Occupational Hazard Survey 1974Hazard Code 82785; Number of Industries 3; Total Number of Facilities 28; Number of Occupations 7; Total Number of Employees Exposed 792

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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