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Registry of Toxic Effects of Chemical Substances (RTECS)

Quinoline

RTECS #

VA9275000

CAS #

91-22-5

Updated

December 2012

Molecular Weight

129.17

Molecular Formula

C9H7N

Synonyms

1-Azanaphthalene
1-Benzazine
B-500
Benzo(b)pyridine
Chinoleine
Chinolin (Czech)
Chinoline
Leucol
Leukol
USAF EK-218

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 100 mg/24H moderate85JCAE -,848,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisembryo/non-mammalian species460 mmol/L/10M-continuousCHROAU 56,289,1976
Cytogenetic Analysisovary/hamster500 µg/LENMUDM 7,1,1985
Cytogenetic Analysislung/hamster100 mg/LATSUDG 4,41,1980
DNA adduct/Escherichia coli30 µmol/LMUREAV 89,95,1981
DNA Damageliver/rat1 mmol/LSinJF# 26OCT1982
micronucleus testintraperitoneal/mouse50 mg/kgTCMUD8 9,111,1989
micronucleus testintraperitoneal/rat75 mg/kgMUREAV 583,133,2005
micronucleus testoral/rat75 mg/kgMUREAV 583,133,2005
morphological transformfibroblast/mouse0.0001 pph/21D (-enzymatic activation step)EMMUEG 37,231,2001
mutation in mammalian somatic cellslymphocyte/mouse700 mg/LEMMUEG 12,85,1988
mutation in mammalian somatic cellsintraperitoneal/mouse200 mg/kg/4D-continuousMUREAV 412,161,1998
mutation in microorganismsovary/hamster80 µmol/L (+enzymatic activation step)ENMUDM 4,395,1982
mutation in microorganisms/Salmonella typhimurium313 µg/plate/20M (+enzymatic activation step)MUTAEX 20,217,2005
mutation in microorganisms/Salmonella typhimurium313 µg/plate/48H (+enzymatic activation step)MUTAEX 20,217,2005
mutation in microorganisms/Salmonella typhimurium25 µg/plate (-enzymatic activation step)MUREAV 174,247,1986
other mutation test systemsintraperitoneal/mouse100 mg/kgMUREAV 747,164,2012
other mutation test systemsembryo/non-mammalian species460 mmol/L/10M-continuousCHROAU 56,289,1976
other mutation test systemsliver/rat500 µmol/LCBINA8 29,257,1980
sister chromatid exchangeovary/hamster110 µg/LENMUDM 7,1,1985
Unscheduled DNA Synthesisliver/rat100 µmol/LMUREAV 221,263,1989

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 9042 µg/kg/15D- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Lymphoma including Hodgkin's disease
JJCREP 78,139,1987
oral/mouse lowest published toxic dose: 50 gm/kg/30W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
GANNA2 68,785,1977
oral/rat lowest published toxic dose: 7770 mg/kg/37W- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
CNREA8 36,329,1976
oral/rat toxic dose: 23 gm/kg/30W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
GANNA2 68,785,1977

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/rat lethal dose (50 percent kill): 331 mg/kg85JCAE -,848,1986
oral/rat lowest published lethal dose: 331 mg/kgMUREAV 747,164,2012
skin/rabbit lethal dose (50 percent kill): 540 µL/kgAMIHBC 4,119,1951
subcutaneous/frog lowest published lethal dose: 150 mg/kgHBAMAK 4,1289,1935
subcutaneous/rabbit lowest published lethal dose: 200 mg/kgHBAMAK 4,1289,1935

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWMUREAV 578,88,2005
TOXICOLOGY REVIEWMUREAV 588,88,2005
TOXICOLOGY REVIEWMUREAV 627,10,2007
TOXICOLOGY REVIEWMUREAV 590,1,2005
TOXICOLOGY REVIEWMUTAEX 26,223,2011
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAtime-weighted average 0.1 mg/m3, short term exposure limit 0.5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84566; Number of Industries 9; Total Number of Facilities 456; Number of Occupations 16; Total Number of Employees Exposed 4241; Total Number of Female Employees Exposed 810
National Occupational Hazard Survey 1974Hazard Code 84566; Number of Industries 7; Total Number of Facilities 258; Number of Occupations 7; Total Number of Employees Exposed 29238

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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