CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Quinoline

RTECS #: VA9275000

CAS #: 91-22-5


UPDATE: August 2008 MW: 129.17 MF: C9H7N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Azanaphthalene
  2. 1 - Benzazine
  3. B - 500
  4. Benzo (b) pyridine
  5. Chinoleine
  1. Chinolin (Czech)
  2. Chinoline
  3. Leucol
  4. Leukol
  5. USAF EK - 218


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
100 mg/24 hour moderate 85JCAE -,848,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 500 g/L ENMUDM 7,1,1985
cytogenetic analysis hamster lung 100 mg/L ATSUDG 4,41,1980
cytogenetic analysis non-mammalian species embryo 460 mmol/L/10 minute- continuous CHROAU 56,289,1976
DNA adduct Escherichia coli 30 mol/L MUREAV 89,95,1981
DNA damage rat liver 1 mmol/L SinJF# 26OCT1982
unscheduled DNA synthesis rat liver 100 mol/L MUREAV 221,263,1989
mutation in microorganisms hamster ovary 80 mol/L (+enzymatic activation step) ENMUDM 4,395,1982
mutation in microorganisms Salmonella typhimurium 25 g/plate (-enzymatic activation step) MUREAV 174,247,1986
mutation in microorganisms Salmonella typhimurium 313 g/plate/20 minute (+enzymatic activation step) MUTAEX 20,217,2005
mutation in microorganisms Salmonella typhimurium 313 g/plate/48 hour (+enzymatic activation step) MUTAEX 20,217,2005
micronucleus test intraperitoneal
mouse
50 mg/kg TCMUD8 9,111,1989
micronucleus test intraperitoneal
rat
75 mg/kg MUREAV 583,133,2005
micronucleus test oral
rat
75 mg/kg MUREAV 583,133,2005
mutation in mammalian somatic cells mouse lymphocyte 700 mg/L EMMUEG 12,85,1988
mutation in mammalian somatic cells intraperitoneal
mouse
200 mg/kg/4 day- continuous MUREAV 412,161,1998
morphological transform mouse fibroblast 0.1 pph/21 day (-enzymatic activation step) EMMUEG 37,231,2001
other mutation test systems non-mammalian species embryo 460 mmol/L/10 minute- continuous CHROAU 56,289,1976
other mutation test systems rat liver 500 mol/L CBINA8 29,257,1980
sister chromatid exchange hamster ovary 110 g/L ENMUDM 7,1,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 9,042 g/kg/15 day- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Lymphoma including Hodgkin's disease
JJCREP 78,139,1987
oral
mouse
lowest published toxic dose: 50 gm/kg/30 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
GANNA2 68,785,1977
oral
rat
lowest published toxic dose: 7,770 mg/kg/37 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
CNREA8 36,329,1976
oral
rat
toxic dose : 23 gm/kg/30 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
GANNA2 68,785,1977


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lethal dose (50 percent kill): 331 mg/kg N/R 85JCAE -,848,1986
subcutaneous
frog
lowest published lethal dose: 150 mg/kg N/R HBAMAK 4,1289,1935
subcutaneous
rabbit
lowest published lethal dose: 200 mg/kg N/R HBAMAK 4,1289,1935
skin
rabbit
lethal dose (50 percent kill): 540 L/kg N/R AMIHBC 4,119,1951


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
MUREAV 578,88,2005
TOXICOLOGY REVIEW
MUREAV 588,88,2005
TOXICOLOGY REVIEW
MUREAV 627,10,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA time-weighted average 0.1 mg/m3, short term exposure limit 0.5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84566;
Number of Industries 7;
Total Number of Facilities 258;
Number of Occupations 7;
Total Number of Employees Exposed 29,238
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84566;
Number of Industries 9;
Total Number of Facilities 456;
Number of Occupations 16;
Total Number of Employees Exposed 4,241;
Total Number of Female Employees Exposed 810


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an antimalarial agent
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1939-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP.
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
SinJF# Personal Communication from J.F. Sina, Merck Institute for Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-

Used as an antimalarial agent

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us