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2 - Pyrrolidinone, 1 - vinyl -

RTECS #: UY6107000

CAS #: 88-12-0


UPDATE: February 2009 MW: 111.16 MF: C6H9NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Ethenyl - 2 - pyrrolidinone (9CI)
  2. 1 - Vinyl - 2 - pyrrolidinone
  3. 1 - Vinyl - 2 - pyrrolidone
  4. N - Vinylpyrrolidinone
  5. N - Vinyl - 2 - pyrrolidinone
  1. N - Vinylpyrrolidone
  2. N - Vinyl - 2 - pyrrolidone
  3. V - Pyrol
  4. Vinylbutyrolactam
  5. Vinylpyrrolidone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg severe BurLW# 02NOV1978


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 10 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Liver: Tumors
FCTOD7 35,1041,1997


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 3,200 mg/m3/4 hour N/R BurLW# 02NOV1978
oral
rat
lethal dose (50 percent kill): 1,470 mg/kg N/R BurLW# 02NOV1978
skin
rabbit
lethal dose (50 percent kill): 560 mg/kg N/R BurLW# 02NOV1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
hamster
lowest published toxic concentration: 45 ppm/6 hour/13 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FCTOD7 35,1061,1997
inhalation
mouse
lowest published toxic concentration: 45 ppm/6 hour/1 week- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 35,1061,1997
inhalation
mouse
lowest published toxic concentration: 5 ppm/6 hour/7 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes
FCTOD7 35,1061,1997
inhalation
rat
lowest published toxic concentration: 45 ppm/6 hour/1 week- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 35,1061,1997
inhalation
rat
lowest published toxic concentration: 15 ppm/6 hour/7 week- intermittent Olfaction: Other olfaction effects FCTOD7 35,1061,1997
inhalation
rat
lowest published toxic concentration: 120 ppm/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FCTOD7 35,1061,1997
inhalation
rat
lowest published toxic concentration: 20 ppm/6 hour/1 year- intermittent Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 35,1061,1997
oral
rat
lowest published toxic dose: 2,600 mg/kg/13 week- intermittent Liver: Other changes

Liver: Changes in liver weight
FCTOD7 35,1061,1997


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,1181,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 19,461,1979
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1181,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal No Adequate Data IMEMDT 19,461,1979
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1181,1999
TOXICOLOGY REVIEW
TPHSDY 24,611,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRIA TRK 0.5 mg/m3 (0.1 mL/m3), JAN 2006
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 ppm (0.23 mg/m3), MAR2002
Occupational Exposure Limit - FRANCE VME 0.1 ppm, continuous3 Carcinogen, FEB2006
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.5 mg/m3), Skin, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84629;
Number of Industries 1;
Total Number of Facilities 1,085;
Number of Occupations 1;
Total Number of Employees Exposed 4,340
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84629;
Number of Industries 6;
Total Number of Facilities 201;
Number of Occupations 11;
Total Number of Employees Exposed 6,772;
Total Number of Female Employees Exposed 1,243


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of POLYVINYL PYRROLIDONE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

BurLW# Personal Communication from L.W. Burnette, Material Safety Dept., GAF Corp., 1361 Alps Rd., Wayne, NJ 07470, Nov. 2, 1978
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-

Used in the manufacture of POLYVINYL PYRROLIDONE

RTECS Compound Description:
   Tumorigen
   Primary Irritant

Click Here for Additional Information about RTECS

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