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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Pyrrolidinone, 1-vinyl-

RTECS #

UY6107000

CAS #

88-12-0

Updated

July 2013

Molecular Weight

111.16

Molecular Formula

C6H9NO

Synonyms

1-Ethenyl-2-pyrrolidinone (9CI)
1-Vinyl-2-pyrrolidinone
1-Vinyl-2-pyrrolidone
N-Vinyl-2-pyrrolidinone
N-Vinyl-2-pyrrolidone
N-Vinylpyrrolidinone
N-Vinylpyrrolidone
Vinylbutyrolactam
Vinylpyrrolidone
V-Pyrol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg severeBurLW# 02NOV1978

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 10 ppm/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Liver: Tumors
FCTOD7 35,1041,1997

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 3200 mg/m3/4HBurLW# 02NOV1978
oral/rat lethal dose (50 percent kill): 1470 mg/kgBurLW# 02NOV1978
skin/rabbit lethal dose (50 percent kill): 560 mg/kgBurLW# 02NOV1978

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/hamster lowest published toxic concentration: 45 ppm/6H/13W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainFCTOD7 35,1061,1997
inhalation/mouse lowest published toxic concentration: 45 ppm/6H/1W- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 35,1061,1997
inhalation/mouse lowest published toxic concentration: 5 ppm/6H/7W- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes
FCTOD7 35,1061,1997
inhalation/rat lowest published toxic concentration: 45 ppm/6H/1W- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 35,1061,1997
inhalation/rat lowest published toxic concentration: 15 ppm/6H/7W- intermittentOlfaction: Other olfaction effectsFCTOD7 35,1061,1997
inhalation/rat lowest published toxic concentration: 120 ppm/6H/13W- intermittentOlfaction: Other olfaction effects

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FCTOD7 35,1061,1997
inhalation/rat lowest published toxic concentration: 20 ppm/6H/1Y- intermittentLiver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 35,1061,1997
oral/rat lowest published toxic dose: 2600 mg/kg/13W- intermittentLiver: Other changes

Liver: Changes in liver weight
FCTOD7 35,1061,1997

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 71,1181,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 19,461,1979
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1181,1999
International Agency for Research on Cancer (IARC)Cancer Review:Animal No Adequate DataIMEMDT 19,461,1979
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,1181,1999
TOXICOLOGY REVIEWTPHSDY 24,611,2003
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWFCTOD7 49,1877,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIATRK-TMW 0.1 ppm (0.5 mg/m3);KZW 0.4 ppm (2 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.05 ppm (0.23 mg/m3), MAR2002
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 ppm (0.5 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 ppm, C3 Carcinogen, FEB2006
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 ppm (0.5 mg/m3), carc 3, skin, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84629; Number of Industries 6; Total Number of Facilities 201; Number of Occupations 11; Total Number of Employees Exposed 6772; Total Number of Female Employees Exposed 1243
National Occupational Hazard Survey 1974Hazard Code 84629; Number of Industries 1; Total Number of Facilities 1085; Number of Occupations 1; Total Number of Employees Exposed 4340

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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