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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Pyrrolidinone, 1-methyl-

RTECS #

UY5790000

CAS #

872-50-4; 26138-58-9

Updated

July 2013

Molecular Weight

99.15

Molecular Formula

C5H9NO

Synonyms

1-Methyl-2-pyrrolidinone
1-Methyl-2-pyrrolidone
1-Methyl-5-pyrrolidinone
M-Pyrol
N-Methyl-2-pyrrolidinone
N-Methyl-2-pyrrolidone
N-Methyl-alpha-pyrrolidone
N-Methylpyrrolidinone
N-Methylpyrrolidone
NMP

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg moderateFCTOD7 26,475,1988

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae154 mmol/LEMMUEG 11,31,1988

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 150 ppm/6H (7-20D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
NETEEC 16,241,1994
inhalation/rat 116 ppm/6H (multigenerations)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)DCTODJ 18,271,1995
intraperitoneal/mouse 7625 mg/kg (11-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
EPASR* 8EHQ-1087-0695
intraperitoneal/rat 166 mg/kg (9D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
BIRUAA 14,38,1976
oral/mouse 12825 mg/kg (11-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
EPASR* 8EHQ-1087-0695
oral/rat 9700 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities
EPASR* 8EHQ-1087-0695
oral/rat 7.5 gm/kg (6-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FCTOD7 40,1705,2002
oral/rat 11.25 gm/kg (6-20D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)FCTOD7 40,1705,2002
oral/rat 7500 mg/kg (6-20D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FCTOD7 40,1705,2002
oral/rat 3750 mg/kg (6-20D pregnant)Reproductive: Other developmental abnormalitiesFCTOD7 40,1705,2002
oral/rat 84000 mg/kg (12W male)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
REPTED 20,453,2005
skin/rat 7500 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FAATDF 2,73,1982
skin/rat 7500 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FAATDF 2,73,1982
skin/rat 7500 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
NTIS** OTS0555033

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 784 gm/kg/78W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** OTS0559204-1

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 1 gm/m3NTIS** OTS0534725
intraperitoneal/mouse lethal dose (50 percent kill): 3050 mg/kgEPASR* 8EHQ-1087-0695
intraperitoneal/rat lethal dose (50 percent kill): 2472 mg/kgARZNAD 26,1581,1976
intravenous/Dog lethal dose (50 percent kill): 63300 µg/kgIYKEDH 18,922,1987
intravenous/mouse lethal dose (50 percent kill): 54500 µg/kgIYKEDH 18,922,1987
intravenous/rat lethal dose (50 percent kill): 80500 µg/kgIYKEDH 18,922,1987
oral/mouse lethal dose (50 percent kill): 5130 mg/kgEPASR* 8EHQ-1087-0695
oral/rat lethal dose (50 percent kill): 3914 mg/kgARZNAD 26,1581,1976
oral/rat lowest published toxic dose: 750 mg/kgBehavioral: Food intake (animal)FCTOD7 40,1705,2002
skin/rabbit lethal dose (50 percent kill): 8 gm/kgNPIRI* 1,84,1974
subcutaneous/rat lethal dose (50 percent kill): >2 gm/kgUSXXAM #4882359
unreported route/rat lethal dose (50 percent kill): 7 gm/kg34ZIAG -,408,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 400 mg/m3/6H/4W- intermittentLung, Thorax, or Respiration: Acute pulmonary edema

Blood: Changes in leukocyte (WBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FAATDF 9,222,1987
inhalation/rat lowest published toxic concentration: 100 ppm/6H/2Y- intermittentKidney, Ureter, and Bladder: Other changes in urine compositionFAATDF 9,222,1987
inhalation/rat lowest published toxic concentration: 423 mg/m3/6H/4W- intermittentBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
NTIS** OTS0534849
inhalation/rat lowest published toxic concentration: 800 ppm/6H/6W- intermittentKidney, Ureter, and Bladder: Other changes in urine compositionNTIS** OTS0532511
inhalation/rat lowest published toxic concentration: 60 ppm/6H/8D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainFCTOD7 41,583,2003
inhalation/rat lowest published toxic concentration: 120 ppm/6H/16D- intermittentBehavioral: Food intake (animal)FCTOD7 41,583,2003
intramuscular/rat lowest published toxic dose: 7500 mg/kg/15D- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 40,1705,2002
oral/mouse lowest published toxic dose: 33600 mg/kg/28D- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 15,83,1995
oral/mouse lowest published toxic dose: 10800 mg/kg/90D- continuousEndocrine: Changes in spleen weightNTIS** OTS0528073
oral/mouse lowest published toxic dose: 630720 mg/kg/2Y- continuousLiver: TumorsTOXID9 60,286,2001
oral/mouse lowest published toxic dose: 12096 mg/kg/2W- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Effect on specific coenzyme: CoA
TOXID9 60,286,2001
oral/mouse lowest published toxic dose: 6048 mg/kg/1W- continuousLiver: Other changesTOXID9 60,286,2001
oral/rat lowest published toxic dose: 2 gm/kg/4D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 40,1705,2002
oral/rat lowest published toxic dose: 655 gm/kg/2Y- intermittentKidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 48,344,1999
oral/rat lowest published toxic dose: 30240 mg/kg/28D- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 15,83,1995
oral/rat lowest published toxic dose: 33750 mg/kg/90D- intermittentBehavioral: Muscle weaknessTOXID9 30,301,1996
skin/rabbit lowest published toxic dose: 32 mL/kg/20D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTIS** OTS0528073

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWENTOX* -,252,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRALIAtime-weighted average 25 ppm (103 mg/m3), short term exposure limit 75 ppm (309 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 20 ppm (80 mg/m3);KZW 80 ppm (320 mg/m3), skin, 2007
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (20 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 10 ppm (40 mg/m3), short term exposure limit 20 ppm (80 mg/m3), skin, NOV2011
Occupational Exposure Limit-GERMANYMAK 20 ppm (82 mg/m3), 2011
Occupational Exposure Limit-GERMANYMAK 20 ppm (82 mg/m3), skin, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 50 ppm (200 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 1 ppm (4 mg/m3), skin, MAY2012
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 25 ppm (103 mg/m3); short term exposure limit 75 ppm (309 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 50 ppm (200 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 25 ppm (101 mg/m3); short term exposure limit 75 ppm (304 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 100 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 50 ppm (200 mg/m3);short term exposure limit 75 ppm (300 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 20 ppm (80 mg/m3), KZG-week 40 ppm (160 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 80 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 25 ppm (103 mg/m3);short term exposure limit 75 ppm (309 mg/m3), skin, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M1569; Number of Industries 63; Total Number of Facilities 3902; Number of Occupations 73; Total Number of Employees Exposed 85169; Total Number of Female Employees Exposed 23478
National Occupational Hazard Survey 1974Hazard Code M1569; Number of Industries 30; Total Number of Facilities 2458; Number of Occupations 43; Total Number of Employees Exposed 25255

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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