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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Pyrrolidinone

RTECS #

UY5715000

CAS #

616-45-5

Updated

August 2009

Molecular Weight

85.12

Molecular Formula

C4H7NO

Synonyms

2-Ketopyrrolidine
2-Oxopyrrolidine
2-Pyrol
2-Pyrrolidone
4-Aminobutyric acid lactam
alpha-Pyrrolidinone
alpha-Pyrrolidone
Butyrolactam
gamma-Aminobutyric acid lactam
gamma-Aminobutyric lactam
gamma-Aminobutyrolactam
gamma-Butyrolactam
LAM
Pyrrolidon (German)
Pyrrolidone

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae352200 µmol/LEMMUEG 11,31,1988

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 19 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Gastrointestinal system
NTIS** OTS0521310-2

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >80 ppm/8HHPV064 -,-,2002
intraperitoneal/mouse lethal dose (50 percent kill): 3700 mg/kgBehavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease
AITEAT 13,70,1965
intraperitoneal/rat lethal dose (50 percent kill): 160 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Dyspnea
TVLMB8 31,160,1979
intravenous/rabbit lowest published lethal dose: 800 mg/kgAITEAT 13,70,1965
intravenous/rat lethal dose (50 percent kill): >7200 mg/kgUSXXAM #3380887
oral/guinea pig lethal dose (50 percent kill): 6500 mg/kg34ZIAG -,508,1969
oral/rat lethal dose (50 percent kill): >5000 mg/kgHPV064 -,-,2002
oral/rat lethal dose (50 percent kill): 8000 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
HPV064 -,-,2002
oral/rat lethal dose (50 percent kill): 328 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Dyspnea
TVLMB8 31,160,1979
skin/rabbit lethal dose (50 percent kill): >2000 mg/kgHPV064 -,-,2002
subcutaneous/mouse lowest published lethal dose: 10 gm/kgAEXPBL 50,199,1903

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 6480 µL/kg/90D- continuousBehavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
NTIS** OTS0521310-3
oral/rat lowest published toxic dose: 52740 mg/kg/90D- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV064 -,-,2002

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code A1513; Number of Industries 2; Total Number of Facilities 35; Number of Occupations 3; Total Number of Employees Exposed 1215; Total Number of Female Employees Exposed 260
National Occupational Hazard Survey 1974Hazard Code A1513; Number of Industries 7; Total Number of Facilities 465; Number of Occupations 15; Total Number of Employees Exposed 2456

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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