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Pyrrolidine

RTECS #: UX9650000

CAS #: 123-75-1


UPDATE: February 2008 MW: 71.14 MF: C4H9N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. STANDARDS AND REGULATIONS:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Azacyclopentane
  2. Azolidine
  3. Prolamine
  1. Pyrrole, tetrahydro -
  2. Tetrahydropyrrole
  3. Tetramethylenimine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 1,300 mg/m3/2 hour Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Vascular: Other changes
GTPZAB 18(2),29,1974
inhalation
mouse
lethal concentration (50 percent kill): 1,000 mg/m3 N/R TPKVAL 14,95,1975
intraperitoneal
mouse
lethal dose (50 percent kill): 420 mg/kg N/R JPETAB 88,82,1946
intravenous
mouse
lethal dose (50 percent kill): 56 mg/kg N/R CSLNX* NX#06769
oral
guinea pig
lowest published lethal dose: 250 mg/kg N/R 85GMAT -,104,1982
oral
mammal (species unspecified)
lethal dose (50 percent kill): 250 mg/kg N/R GISAAA 39(4),86,1974
oral
mouse
lethal dose (50 percent kill): 450 mg/kg N/R BCFAAI 103,414,1964
oral
rat
lethal dose (50 percent kill): 300 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Vascular: Other changes
GTPZAB 18(2),29,1974
oral
rabbit
lowest published lethal dose: 250 mg/kg N/R 85GMAT -,104,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 2.6 mg/m3/182 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TPKVAL 14,95,1975


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894-
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

NIOSH PROFILE (AMINES, SECONDARY ALIPHATIC), SRI, 2/77

RTECS Compound Description:
   Mutagen

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