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Registry of Toxic Effects of Chemical Substances (RTECS)

Pyrogallol

RTECS #

UX2800000

CAS #

87-66-1

Updated

April 2013

Molecular Weight

126.12

Molecular Formula

C6H6O3

Synonyms

1,2,3-Benzenetriol
1,2,3-Trihydroxybenzen (Czech)
1,2,3-Trihydroxybenzene
Benzene, 1,2,3-trihydroxy-
C.I. 76515
C.I. Oxidation Base 32
Fouramine Brown AP
Fourrine 85
Fourrine PG
Pyrogallic acid

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg/24H moderate85JCAE -,235,1986
skin /mouse 0.125%TOXID9 72,52,2003
skin /rabbit 2 mg/24H severe85JCAE -,235,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisintraperitoneal/mouse100 µmol/kgIJMRAQ 59,1442,1971
Cytogenetic Analysisovary/hamster100 mg/LCALEDQ 14,251,1981
Cytogenetic Analysislung/hamster60 µmol/L/2HMUREAV 540,29,2003
DNA adduct/Escherichia coli30 µmol/LMUREAV 89,95,1981
DNA repair/Bacillus subtilis50 mg/LESKGA2 32,171,1986
gene conversion and mitotic recombination/Saccharomyes cerevisiae300 mg/LMUREAV 135,109,1984
micronucleus testintraperitoneal/mouse252 mg/kgMUREAV 90,91,1981
micronucleus testoral/mouse504 mg/kgMUREAV 90,91,1981
micronucleus testlung/hamster50 µmol/LEVHPAZ 82,81,1989
mutation in microorganisms/Salmonella typhimurium1 µmol/plate (+/-enzymatic activation step)NEZAAQ 38,533,1983
mutation in microorganisms/Escherichia coli78 µg/plate (-enzymatic activation step)MUREAV 412,17,1998
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster125 mmol/LMUREAV 90,91,1981
sister chromatid exchangelung/hamster25 µmol/LEVHPAZ 82,81,1989

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 3 gm/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
JACTDZ 2(4),325,1983
subcutaneous/rat 5 mg/kg (1D prior to copulation)Reproductive: Maternal effects: Ovaries, fallopian tubesENDOAO 57,466,1955

Tumorigenic Data and References

Route/OrganismDoseEffectReference
subcutaneous/rat lowest published toxic dose: 3950 mg/kg/58W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
PAACA3 20,117,1979

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Rat, endocrine tumor Inhibitor Concentration Low: 1.34 µmol/LNutritional and Gross Metabolic: Changes in: CaFCTOD7 50,390,2012
In Vitro/Rat, endocrine tumor Inhibitor Concentration Low: 0.048 µmol/LBiochemical: Neurotransmitters or modulators (putative): Dopamine at other sitesFCTOD7 50,390,2012
intraperitoneal/mouse lethal dose (50 percent kill): 400 mg/kgNTIS** AD691-490
intraperitoneal/mouse lethal dose (50 percent kill): 400 mg/kgBehavioral: Tetany

Vascular: BP lowering not characterized in autonomic section

Blood: Other hemolysis with or without anemia
VCVGK* -,238,1994
intravenous/Dog lowest published lethal dose: 80 mg/kgHBTXAC 1,254,1955
intravenous/Dog lowest published lethal dose: 80 mg/kgBehavioral: Tetany

Vascular: BP lowering not characterized in autonomic section

Blood: Other hemolysis with or without anemia
VCVGK* -,238,1994
oral/Dog lowest published lethal dose: 250 mg/kgBehavioral: Tetany

Vascular: BP lowering not characterized in autonomic section

Blood: Other hemolysis with or without anemia
VCVGK* -,238,1994
oral/Dog lowest published lethal dose: 25 mg/kgHBTXAC 1,254,1955
oral/human lowest published lethal dose: 28 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Other changes
34ZIAG -,507,1969
oral/mouse lethal dose (50 percent kill): 300 mg/kgGISAAA 38(8),6,1973
oral/mouse lethal dose (50 percent kill): 570 mg/kgBehavioral: Tetany

Vascular: BP lowering not characterized in autonomic section

Blood: Other hemolysis with or without anemia
VCVGK* -,238,1994
oral/rabbit lethal dose (50 percent kill): 1600 mg/kgBehavioral: Tetany

Vascular: BP lowering not characterized in autonomic section

Blood: Other hemolysis with or without anemia
VCVGK* -,238,1994
oral/rabbit lethal dose (50 percent kill): 1600 mg/kgGastrointestinal: Gastritis

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion
AJVRAH 23,1264,1962
oral/rat lethal dose (50 percent kill): 790 mg/kgBehavioral: Tetany

Vascular: BP lowering not characterized in autonomic section

Blood: Other hemolysis with or without anemia
VCVGK* -,238,1994
oral/wild bird lethal dose (50 percent kill): 75 mg/kgAECTCV 12,355,1983
subcutaneous/Dog lowest published lethal dose: 300 mg/kgHBTXAC 1,254,1955
subcutaneous/Dog lowest published lethal dose: 300 mg/kgBehavioral: Tetany

Vascular: BP lowering not characterized in autonomic section

Blood: Other hemolysis with or without anemia
VCVGK* -,238,1994
subcutaneous/frog lowest published lethal dose: 200 mg/kgEye: Miosis (pupilliary constriction)

Behavioral: Muscle weakness

Behavioral: Ataxia
RMSRA6 15,561,1895
subcutaneous/guinea pig lowest published lethal dose: 800 mg/kgBehavioral: Tetany

Vascular: BP lowering not characterized in autonomic section

Blood: Other hemolysis with or without anemia
VCVGK* -,238,1994
subcutaneous/man lowest published lethal dose: 120 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Gastrointestinal: Changes in structure or function of salivary glands
ZMWIAJ 19,545,1881
subcutaneous/mouse lethal dose (50 percent kill): 566 mg/kgZGIMAL 2,333,1947
subcutaneous/rabbit lowest published lethal dose: 1 gm/kgHBAMAK 4,1289,1935
subcutaneous/rabbit lowest published lethal dose: 1000 mg/kgBehavioral: Tetany

Vascular: BP lowering not characterized in autonomic section

Blood: Other hemolysis with or without anemia
VCVGK* -,238,1994
subcutaneous/rat lowest published lethal dose: 650 mg/kgJAFCAU 17,497,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 1120 mg/kg/4W- intermittentLiver: Other changesFCTOD7 48,1660,2010
intraperitoneal/rat lowest published toxic dose: 175 mg/kg/7D- intermittentImmunological Including Allergic: Decrease in humoral immune responseINJPD2 36,355,2004
intraperitoneal/rat lowest published toxic dose: 350 mg/kg/7D- intermittentImmunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
INJPD2 36,355,2004
oral/chicken lowest published toxic dose: 98 gm/kg/4W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldFEPRA7 29,568,1970
oral/rat lowest published toxic dose: 1200 mg/kg/60D- intermittentBlood: Changes in cell count (unspecified)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
VCVGK* -,238,1994
oral/rat lowest published toxic dose: 15200 mg/kg/152D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
VCVGK* -,238,1994

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 47,75,1978
TOXICOLOGY REVIEWMUREAV 539,77,2003
TOXICOLOGY REVIEWMUREAV 588,129,2005
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWMUREAV 721,27,2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81963; Number of Industries 8; Total Number of Facilities 2175; Number of Occupations 14; Total Number of Employees Exposed 38038; Total Number of Female Employees Exposed 24931
National Occupational Hazard Survey 1974Hazard Code 81963; Number of Industries 22; Total Number of Facilities 848; Number of Occupations 25; Total Number of Employees Exposed 19191

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000
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