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Registry of Toxic Effects of Chemical Substances (RTECS)

Pyridine, 2-vinyl-

RTECS #

UU1040000

CAS #

100-69-6

Updated

April 2012

Molecular Weight

105.15

Molecular Formula

C7H7N

Synonyms

2-Ethenylpyridine
2-Vinylpyridine
alpha-Vinylpyridine
Pyridine, 2-ethenyl- (9CI)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /guinea pig 0.1 mL severeHPV065 -,-,2003
skin /rabbit 0.5 mL severeHPV065 -,-,2003

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in mammalian somatic cellsfibroblast/hamster5.57 mg/L/24H (+/-enzymatic activation step)HPV065 -,-,2003

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 460 mg/m3GTPZAB 10(3),9,1966
inhalation/rat lethal concentration (50 percent kill): 610 mg/m3GISAAA 57(9-10),64,1992
oral/mammal (species unspecified) lethal dose (50 percent kill): 415 mg/kgGISAAA 39(4),86,1974
oral/mouse lethal dose (50 percent kill): 420 mg/kgGTPZAB 10(3),9,1966
oral/rat lethal dose (50 percent kill): 951 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea
HPV065 -,-,2003
oral/rat lethal dose (50 percent kill): 100 mg/kg85JCAE -,845,1986
skin/guinea pig lowest published lethal dose: 0.1 mL/kgHPV065 -,-,2003
skin/guinea pig lethal dose (50 percent kill): 0.16 mL/kgHPV065 -,-,2003
skin/guinea pig lowest published lethal dose: 500 mg/kg85JCAE -,845,1986
skin/rabbit lethal dose (50 percent kill): 0.64 gm/kgSkin: After topical application: CorrosiveHPV065 -,-,2003
skin/rabbit lowest published lethal dose: 300 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression
HPV065 -,-,2003

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 5 mg/m3/4H/48W- intermittentBehavioral: Alteration of classical conditioning

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 10(3),9,1966
oral/rat lowest published toxic dose: 1040 mg/kg/17D- intermittentGastrointestinal: Gastritis

Liver: Changes in liver weight
HPV065 -,-,2003
oral/rat lowest published toxic dose: 2600 mg/kg/17D- intermittentGastrointestinal: Ulceration or bleeding from stomach

Liver: Changes in liver weight

Blood: Changes in leukocyte (WBC) count
HPV065 -,-,2003
oral/rat lowest published toxic dose: 6500 mg/kg/17D- intermittentGastrointestinal: Ulceration or bleeding from stomach

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV065 -,-,2003

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 588,129,2005
TOXICOLOGY REVIEWMUREAV 741,32,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, Skin, JUN2003

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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