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Registry of Toxic Effects of Chemical Substances (RTECS)

Pyridine, 2-(1-methyl-2-(4-phenoxyphenoxy)ethoxy)-

RTECS #

UT5804000

CAS #

95737-68-1

Updated

October 2010

Molecular Weight

321.40

Molecular Formula

C20H19NO3

Synonyms

2-(1-Methyl-2-(4-phenoxyphenoxy)ethoxy)pyridine
4-Phenoxyphenyl (RS)-2-(2-pyridyloxy)propyl ether
Pyriproxyfen
S 31183
S 9138
SK 591

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 3300 mg/kg (7-17D pregnant)Reproductive: Other effects to embryo or fetusFEREAC 69,76724,2004
oral/rabbit 3900 mg/kg (6-18D pregnant)Reproductive: Effects on fertility: Other measures of fertilityFEREAC 69,76724,2004

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/rat lethal dose (50 percent kill): >2000 mg/kgFEREAC 68,11093,2003
skin/rat lethal dose (50 percent kill): >2 gm/kgPEMNDP 9,745,1991

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1000 gm/m3/28D- intermittentGastrointestinal: Changes in structure or function of salivary glands

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
FEREAC 68,10972,2003
inhalation/rat lowest published toxic concentration: 1000 gm/m3/28D- intermittentGastrointestinal: Changes in structure or function of salivary glandsFEREAC 68,10972,2003
inhalation/rat lowest published toxic concentration: 1000 mg/m3/4W- intermittentBehavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 69,76724,2004
oral/Dog lowest published toxic dose: 109500 mg/kg/1Y- intermittentLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FEREAC 69,76724,2004
oral/Dog lowest published toxic dose: 27000 mg/kg/90D- continuousLiver: Changes in liver weightFEREAC 68,10972,2003
oral/mouse lowest published toxic dose: 75429 mg/kg/90D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes

Blood: Other changes
FEREAC 67,55150,2002
oral/mouse lowest published toxic dose: 75429 mg/kg/90D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 68,10972,2003
oral/mouse lowest published toxic dose: 86751 mg/kg/90D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in erythrocyte (RBC) count
FEREAC 68,10972,2003
oral/mouse lowest published toxic dose: 229320 mg/kg/78W- continuousKidney, Ureter, and Bladder: Other changesFEREAC 69,76724,2004
oral/rabbit lowest published toxic dose: 3900 mg/kg/13D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FEREAC 69,76724,2004
oral/rat lowest published toxic dose: 3300 mg/kg/11D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FEREAC 69,76724,2004
oral/rat lowest published toxic dose: 10601.1 mg/kg/90D- continuousLiver: Changes in liver weight

Blood: Changes in erythrocyte (RBC) count

Biochemical: Metabolism (intermediary): Lipids including transport
FEREAC 68,10972,2003
oral/rat lowest published toxic dose: 12715.2 mg/kg/90D- continuousBlood: Other changesFEREAC 68,10972,2003
oral/rat lowest published toxic dose: 133371 mg/kg/2Y- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainFEREAC 69,76724,2004

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWFEREAC 72,46914,2007
TOXICOLOGY REVIEWFEREAC 74,15971,2009
TOXICOLOGY REVIEWFEREAC 74,55463,2009

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESActive registrationRBREV* -,390,1998
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