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Pyridine, 2 - (1 - methyl - 2 - (4 - phenoxyphenoxy) ethoxy) -

RTECS #: UT5804000

CAS #: 95737-68-1


UPDATE: February 2009 MW: 321.40 MF: C20H19NO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. REFERENCES:

SYNONYMS:

  1. 2 - (1 - Methyl - 2 - (4 - phenoxyphenoxy) ethoxy) pyridine
  2. 4 - Phenoxyphenyl (RS) - 2 - (2 - pyridyloxy) propyl ether
  3. Pyriproxyfen
  1. S 31183
  2. S 9138
  3. SK 591


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 3,300 mg/kg (7-17 day pregnant) Reproductive: Other effects to embryo or fetus FEREAC 69,76724,2004
oral
rabbit
lowest published toxic dose: 3,900 mg/kg (6-18 day pregnant) Reproductive: Effects on fertility: Other measures of fertility FEREAC 69,76724,2004


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lethal dose (50 percent kill): >2,000 mg/kg N/R FEREAC 68,11093,2003
skin
rat
lethal dose (50 percent kill): >2 gm/kg N/R PEMNDP 9,745,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 1,000 gm/m3/28 day- intermittent Gastrointestinal: Changes in structure or function of salivary glands

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
FEREAC 68,10972,2003
inhalation
rat
lowest published toxic concentration: 1,000 gm/m3/28 day- intermittent Gastrointestinal: Changes in structure or function of salivary glands FEREAC 68,10972,2003
inhalation
rat
lowest published toxic concentration: 1,000 mg/m3/4 week- intermittent Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 69,76724,2004
oral
dog
lowest published toxic dose: 27,000 mg/kg/90 day- continuous Liver: Changes in liver weight FEREAC 68,10972,2003
oral
dog
lowest published toxic dose: 109,500 mg/kg/1 year- intermittent Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FEREAC 69,76724,2004
oral
mouse
lowest published toxic dose: 75,429 mg/kg/90 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes

Blood: Other changes
FEREAC 67,55150,2002
oral
mouse
lowest published toxic dose: 75,429 mg/kg/90 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 68,10972,2003
oral
mouse
lowest published toxic dose: 86,751 mg/kg/90 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in erythrocyte (RBC) count
FEREAC 68,10972,2003
oral
mouse
lowest published toxic dose: 229,320 mg/kg/78 week- continuous Kidney, Ureter, and Bladder: Other changes FEREAC 69,76724,2004
oral
rat
lowest published toxic dose: 10,601.1 mg/kg/90 day- continuous Liver: Changes in liver weight

Blood: Changes in erythrocyte (RBC) count

Biochemical: Metabolism (intermediary): Lipids including transport
FEREAC 68,10972,2003
oral
rat
lowest published toxic dose: 12,715.2 mg/kg/90 day- continuous Blood: Other changes FEREAC 68,10972,2003
oral
rat
lowest published toxic dose: 3,300 mg/kg/11 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FEREAC 69,76724,2004
oral
rat
lowest published toxic dose: 133,371 mg/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain FEREAC 69,76724,2004
oral
rabbit
lowest published toxic dose: 3,900 mg/kg/13 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FEREAC 69,76724,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
FEREAC 72,46914,2007
TOXICOLOGY REVIEW
FEREAC 72,46914,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Active registration RBREV* -,390,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

N/R


REFERENCES:

CODEN
REFERENCE

FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998

RTECS Compound Description:
   Agricultural Chemical
   Reproductive Effector

Click Here for Additional Information about RTECS

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