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Registry of Toxic Effects of Chemical Substances (RTECS)

Pyridine, 4-methyl-

RTECS #

UT5425000

CAS #

108-89-4

Updated

April 2010

Molecular Weight

93.14

Molecular Formula

C6H7N

Synonyms

4-Methylpyridine
4-Picoline (8CI)
Ba 35846
gamma-Picoline
p-Methylpyridine
p-Picoline

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg/24H moderate85JCAE -,841,1986
skin /rabbit 480 mg open irritation test moderateUCDS** 2/21/1958

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 4 gm/m3GISAAA 57(9-10),64,1992
inhalation/rat Lowest published lethal concentration: 1000 ppm/4HAMIHBC 10,61,1954
inhalation/rat Lowest published lethal concentration: 9170 mg/m3/5HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
HPV361 -,-,2003
inhalation/rat Lowest published lethal concentration: 17500 mg/m3/2.5HLung, Thorax, or Respiration: Respiratory depression

Liver: Other changes

Blood: Hemorrhage
HPV361 -,-,2003
inhalation/rat lethal concentration (50 percent kill): >1000 ppm/4HHPV361 -,-,2003
intraperitoneal/mouse lethal dose (50 percent kill): 335 mg/kgTOXIA6 23,815,1985
intraperitoneal/rat lethal dose (50 percent kill): 163 mg/kgBehavioral: Somnolence (general depressed activity)FAATDF 5,920,1985
oral/mouse lethal dose (50 percent kill): 350 mg/kgGISAAA 57(9-10),64,1992
oral/rat lethal dose (50 percent kill): 440 mg/kgGISAAA 57(9-10),64,1992
oral/rat lethal dose (50 percent kill): 700 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
HPV361 -,-,2003
oral/wild bird lethal dose (50 percent kill): 422 mg/kgAECTCV 12,355,1983
skin/guinea pig lowest published lethal dose: 500 mg/kg85JCAE -,841,1986
skin/rabbit lowest published lethal dose: 126 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
HPV361 -,-,2003
skin/rabbit lethal dose (50 percent kill): 0.27 mL/kgHPV361 -,-,2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X7969; Number of Industries 3; Total Number of Facilities 55; Number of Occupations 7; Total Number of Employees Exposed 9556; Total Number of Female Employees Exposed 1119

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9273
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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