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Pyrene

RTECS #: UR2450000

CAS #: 129-00-0


UPDATE: May 2008 MW: 202.26 MF: C16H10


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Benzo (def) phenanthrene
  2. Coal tar pitch volatiles:pyrene (OSHA)
  1. Pyren (German)
  2. beta - Pyrene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 mg/24 hour mild 28ZPAK -,26,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 10 mg/L ESKHA5 (103),64,1985
DNA adduct Escherichia coli 10 µmol/L PNCCA2 5,39,1965
DNA adduct non-mammalian species 8,600 nmol/L GANMAX 6,49,1968
DNA adduct salmon testis 5 µg/1 hour- continuous BIJOAK 110,159,1968
DNA damage Escherichia coli 461.8 µg/L/3 hour (+enzymatic activation step) MUREAV 515,85,2002
DNA damage hamster fibroblast 10 µmol/L/2 hour (-enzymatic activation step) MUREAV 650,96,2008
DNA damage human leukocyte 12,500 nmol/L MUREAV 468,93,2000
DNA damage mouse lymphocyte 50 µmol/L MUREAV 203,155,1988
unscheduled DNA synthesis hamster liver 100 µmol/L ENMUDM 5,1,1983
unscheduled DNA synthesis human fibroblast 100 mg/L TXCYAC 21,151,1981
unscheduled DNA synthesis rat liver 2,500 µmol/L CNREA8 42,3010,1982
mutation in microorganisms Escherichia coli 1 µg/plate (+enzymatic activation step) PMRSDJ 1,387,1981
mutation in microorganisms mouse lymphocyte 10,100 nmol/L (+enzymatic activation step) MUTAEX 3,193,1988
mutation in microorganisms Salmonella typhimurium 5 µg/plate (+enzymatic activation step) DTESD7 2,249,1977
mutation in microorganisms Salmonella typhimurium 300 ng/plate (-enzymatic activation step) ENMUDM 6(Suppl 2),1,1984
mutation in microorganisms Salmonella typhimurium 0.5 nmol/plate/48 hour (-enzymatic activation step) MUREAV 557,99,2004
mutation in microorganisms Salmonella typhimurium 4 mg/L/72 hour (+enzymatic activation step) MUREAV 558,181,2004
micronucleus test multiple
non-mammalian species
900 nmol/L MUTAEX 4,17,1989
mutation in mammalian somatic cells human other cell types 12 µmol/L MUREAV 130,127,1984
mutation in mammalian somatic cells mouse lymphocyte 1,510 µmol/L MUTAEX 3,193,1988
mutation in mammalian somatic cells rat embryo 10 mg/L JTEHD6 4,79,1978
morphological transform hamster embryo 10 mg/L CNREA8 31,1118,1971
morphological transform hamster kidney 62,500 µg/L PMRSDJ 1,626,1981
morphological transform mouse embryo 10 mg/L EMMUEG 12,21,1988
morphological transform mouse embryo 10 mg/L/12 day MUREAV 588,7,2005
other mutation test systems Escherichia coli 50 nmol/tube MUREAV 147,79,1985
sister chromatid exchange human lymphocyte 100 µmol/L MUREAV 211,77,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
mouse
lowest published toxic dose: 10 gm/kg/3 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
BJCAAI 10,363,1956


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 170 mg/m3 Eye: Conjunctiva irritation

Behavioral: Excitement

Behavioral: Muscle contraction or spasticity
GTPZAB 15(2),59,1971
inhalation
rat
lethal concentration (50 percent kill): 170 mg/m3 N/R VCVGH* -,235,1990
intraperitoneal
mouse
lethal dose (50 percent kill): 514 mg/kg N/R PMRSDJ 1,682,1981
oral
mouse
lethal dose (50 percent kill): 800 mg/kg Eye: Conjunctiva irritation

Behavioral: Excitement

Behavioral: Muscle contraction or spasticity
GTPZAB 15(2),59,1971
oral
mouse
lowest published toxic dose: 6,068 µg/kg Liver: Changes in liver weight

Endocrine: Changes in thymus weight
TOXID9 78,397,2004
oral
mouse
lethal dose (50 percent kill): 800 mg/kg N/R ENTOX* -,513,2005
oral
rat
lethal dose (50 percent kill): 2,700 mg/kg Eye: Conjunctiva irritation

Behavioral: Excitement

Behavioral: Muscle contraction or spasticity
GTPZAB 15(2),59,1971
oral
rat
lethal dose (50 percent kill): 2.7 gm/kg N/R ENTOX* -,513,2005
unreported route
mouse
lethal dose (50 percent kill): 800 mg/kg N/R VCVGH* -,235,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 404 mg/kg/7 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain ARTODN 77,183,2003
multiple
rat
lowest published toxic dose: 303.39 mg/kg/3 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
ARTODN 81,169,2007
oral
mouse
lowest published toxic dose: 21 mg/kg/7 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,398,2004
oral
mouse
lowest published toxic dose: 35 mg/kg/7 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,398,2004
oral
mouse
lowest published toxic dose: 42,475 µg/kg/7 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 78,397,2004
oral
mouse
lowest published toxic dose: 820 mg/kg/4 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
TXCYAC 238,147,2007
oral
rat
lowest published toxic dose: 12,150 mg/kg/45 day- intermittent Behavioral: Muscle contraction or spasticity

Blood: Normocytic anemia

Blood: Changes in erythrocyte (RBC) count
GTPZAB 15(2),59,1971
unreported route
mouse
lowest published toxic dose: 180 mg/kg/12 day- intermittent Immunological Including Allergic: Uncharacterized (multiple organ involvement) TOXID9 48,13,1999


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 32,431,1983
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 32,431,1983
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
MUREAV 558,155,2004
TOXICOLOGY REVIEW
MUREAV 558,7,2004
TOXICOLOGY REVIEW
MUREAV 540,89,2003
TOXICOLOGY REVIEW
TOLED5 140-141,353,2003
TOXICOLOGY REVIEW
MUREAV 567,401,2004
TOXICOLOGY REVIEW
MUREAV 589,208,2005
TOXICOLOGY REVIEW
ENTOX* -,513,2005
TOXICOLOGY REVIEW
ENTOX* -,513,2005
TOXICOLOGY REVIEW
MUREAV 636,95,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.2 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.2 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.2 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.2 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - RUSSIA short term exposure limit 0.03 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T1328;
Number of Industries 1;
Total Number of Facilities 11;
Number of Occupations 1;
Total Number of Employees Exposed 32
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T1328;
Number of Industries 3;
Total Number of Facilities 560;
Number of Occupations 3;
Total Number of Employees Exposed 9,387


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264370)
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-BALB/c-3T3; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-mouse embryo
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-nonhuman; Host-mediated assay
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; In vivo SCE-nonhuman
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse; In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Negative: V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat; Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an industrial chemical
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC, 5506; by GC, 5515
OSHA ANALYTICAL METHOD #ID-58


REFERENCES:

CODEN
REFERENCE

28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTESD7 Developments in Toxicology and Environtal Science. (Elsevier Science, New York, NY) V.1-15, 1977-87. Discontinued
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
GANMAX Gann Monograph. (Tokyo, Japan) No.1-10, 1966-71. For publisher information, see GMCRDC.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981-
PNCCA2 Proceedings, National Cancer Conference. (Philadelphia, PA) V.1-7, 1949-72. For publisher information, see CANCAR.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as an industrial chemical

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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