Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Pyrene

RTECS #

UR2450000

CAS #

129-00-0

Updated

July 2013

Molecular Weight

202.26

Molecular Formula

C16H10

Synonyms

Benzo(def)phenanthrene
beta-Pyrene
Coal tar pitch volatiles:pyrene (OSHA)
Pyren (German)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg/24H mild28ZPAK -,26,1972

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster10 mg/LESKHA5 (103),64,1985
DNA adduct/Escherichia coli10 µmol/LPNCCA2 5,39,1965
DNA adduct/non-mammalian species8600 nmol/LGANMAX 6,49,1968
DNA adducttestis/salmon5 µg/1H-continuousBIJOAK 110,159,1968
DNA Damageleukocyte/human12500 nmol/LMUREAV 468,93,2000
DNA Damagelymphocyte/mouse50 µmol/LMUREAV 203,155,1988
DNA Damage/Escherichia coli461.8 µg/L/3H (+enzymatic activation step)MUREAV 515,85,2002
DNA Damagefibroblast/hamster10 µmol/L/2H (-enzymatic activation step)MUREAV 650,96,2008
micronucleus testmultiple/non-mammalian species900 nmol/LMUTAEX 4,17,1989
morphological transformembryo/hamster10 mg/LCNREA8 31,1118,1971
morphological transformkidney/hamster62500 µg/LPMRSDJ 1,626,1981
morphological transformembryo/mouse10 mg/LEMMUEG 12,21,1988
morphological transformembryo/mouse10 mg/L/12DMUREAV 588,7,2005
mutation in mammalian somatic cellslymphocyte/mouse1510 µmol/LMUTAEX 3,193,1988
mutation in mammalian somatic cellsembryo/rat10 mg/LJTEHD6 4,79,1978
mutation in mammalian somatic cellsother cell types/human12 µmol/LMUREAV 130,127,1984
mutation in microorganisms/Escherichia coli1 µg/plate (+enzymatic activation step)PMRSDJ 1,387,1981
mutation in microorganismslymphocyte/mouse10100 nmol/L (+enzymatic activation step)MUTAEX 3,193,1988
mutation in microorganisms/Salmonella typhimurium5 µg/plate (+enzymatic activation step)DTESD7 2,249,1977
mutation in microorganisms/Salmonella typhimurium300 ng/plate (-enzymatic activation step)ENMUDM 6(Suppl 2),1,1984
mutation in microorganisms/Salmonella typhimurium0.5 nmol/plate/48H (-enzymatic activation step)MUREAV 557,99,2004
mutation in microorganisms/Salmonella typhimurium4 mg/L/72H (+enzymatic activation step)MUREAV 558,181,2004
mutation in microorganisms/Salmonella typhimurium0.224 mg/L/48H (+enzymatic activation step)MUREAV 750,12,2013
other mutation test systems/Escherichia coli50 nmol/tubeMUREAV 147,79,1985
sister chromatid exchangelymphocyte/human100 µmol/LMUREAV 211,77,1989
Unscheduled DNA Synthesisliver/rat2500 µmol/LCNREA8 42,3010,1982
Unscheduled DNA Synthesisfibroblast/human100 mg/LTXCYAC 21,151,1981
Unscheduled DNA Synthesisliver/hamster100 µmol/LENMUDM 5,1,1983

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 10 gm/kg/3W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
BJCAAI 10,363,1956

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 170 mg/m3Eye: Conjunctiva irritation

Behavioral: Excitement

Behavioral: Muscle contraction or spasticity
GTPZAB 15(2),59,1971
inhalation/rat lethal concentration (50 percent kill): 170 mg/m3VCVGH* -,235,1990
intraperitoneal/mouse lethal dose (50 percent kill): 514 mg/kgPMRSDJ 1,682,1981
oral/mouse lethal dose (50 percent kill): 800 mg/kgEye: Conjunctiva irritation

Behavioral: Excitement

Behavioral: Muscle contraction or spasticity
GTPZAB 15(2),59,1971
oral/mouse lowest published toxic dose: 6068 µg/kgLiver: Changes in liver weight

Endocrine: Changes in thymus weight
TOXID9 78,397,2004
oral/mouse lethal dose (50 percent kill): 800 mg/kgENTOX* -,513,2005
oral/rat lethal dose (50 percent kill): 2.7 gm/kgENTOX* -,513,2005
oral/rat lethal dose (50 percent kill): 2700 mg/kgEye: Conjunctiva irritation

Behavioral: Excitement

Behavioral: Muscle contraction or spasticity
GTPZAB 15(2),59,1971
unreported route/mouse lethal dose (50 percent kill): 800 mg/kgVCVGH* -,235,1990

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 404 mg/kg/7D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainARTODN 77,183,2003
multiple/rat lowest published toxic dose: 303.39 mg/kg/3D- intermittentLung, Thorax, or Respiration: Other changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
ARTODN 81,169,2007
oral/mouse lowest published toxic dose: 21 mg/kg/7D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,398,2004
oral/mouse lowest published toxic dose: 35 mg/kg/7D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,398,2004
oral/mouse lowest published toxic dose: 42475 µg/kg/7D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 78,397,2004
oral/mouse lowest published toxic dose: 820 mg/kg/4D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
TXCYAC 238,147,2007
oral/rat lowest published toxic dose: 12150 mg/kg/45D- intermittentBehavioral: Muscle contraction or spasticity

Blood: Normocytic anemia

Blood: Changes in erythrocyte (RBC) count
GTPZAB 15(2),59,1971
unreported route/mouse lowest published toxic dose: 180 mg/kg/12D- intermittentImmunological Including Allergic: Uncharacterized (multiple organ involvement)TOXID9 48,13,1999

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 32,431,1983
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 32,431,1983
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWMUREAV 558,155,2004
TOXICOLOGY REVIEWMUREAV 558,7,2004
TOXICOLOGY REVIEWMUREAV 540,89,2003
TOXICOLOGY REVIEWTOLED5 140-141,353,2003
TOXICOLOGY REVIEWMUREAV 567,401,2004
TOXICOLOGY REVIEWMUREAV 589,208,2005
TOXICOLOGY REVIEWENTOX* -,513,2005
TOXICOLOGY REVIEWMUREAV 636,95,2007
TOXICOLOGY REVIEWMUREAV 636,144,2007
TOXICOLOGY REVIEWMUREAV 636,36,2007
TOXICOLOGY REVIEWMUTAEX 23,271,2008

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.03 mg/m3, Skin, JUN2003
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.2 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.2 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.2 mg/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.2 mg/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code T1328; Number of Industries 3; Total Number of Facilities 560; Number of Occupations 3; Total Number of Employees Exposed 9387
National Occupational Hazard Survey 1974Hazard Code T1328; Number of Industries 1; Total Number of Facilities 11; Number of Occupations 1; Total Number of Employees Exposed 32

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264370)
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat; Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-BALB/c-3T3; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-mouse embryo
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; In vivo SCE-nonhuman
EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-nonhuman; Host-mediated assay
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse; In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Negative: V79 cell culture-gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC, 5506; by GC, 5515
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID-58
TOP