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1H - Pyrazole - 3 - carbonitrile, 5 - amino - 1 - (2,6 - dichloro - 4 - (trifluoromethyl) phenyl) - 4 - ( (trifluoromethyl) sulfinyl) -

RTECS #: UQ4430250

CAS #: 120068-37-3

UPDATE: May 2009 MW: 437.16 MF: C12H4Cl2F6N4OS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Fipronil
  2. M & B 46030
  1. Regent


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mammal (species unspecified) 		lowest published toxic dose: 390 mg/kg (6-22 day pregnant/10 day after birth) Reproductive: Effects on newborn: Behavioral FEREAC 63,38486,1998


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 0.39 gm/m3 N/R ENTOX* -,334,2005
oral
wild bird 		lethal dose (50 percent kill): 1,120 mg/kg N/R ENTOX* -,334,2005
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 92 mg/kg N/R FEREAC 63,38488,1998
oral
man 		lowest published lethal dose: 1.43 mL/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Skin and Appendages: Other: Sweating 		JTCTDW 42,955,2004
oral
mouse 		lethal dose (50 percent kill): 95 mg/kg N/R ENTOX* -,334,2005
oral
rat 		lowest published toxic dose: 100 mg/kg Brain and Coverings: Changes in surface EEG

Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Change in motor activity (specific assay) 		TXCYAC 214,67,2005
oral
rat 		lethal dose (50 percent kill): 97 mg/kg N/R ENTOX* -,334,2005
skin
rat 		lethal dose (50 percent kill): >2 gm/kg N/R ENTOX* -,334,2005
skin
rabbit 		lethal dose (50 percent kill): 354 mg/kg N/R ENTOX* -,334,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 910 mg/kg/13 week- intermittent Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0555596
oral
mouse 		lowest published toxic dose: 554 mg/kg/6 week- continuous Behavioral: Irritability

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0555580
oral
mouse 		lowest published toxic dose: 288 mg/kg/90 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain FEREAC 70,49599,2005
oral
rat 		lowest published toxic dose: 420 mg/kg/2 week- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0571733
oral
rat 		lowest published toxic dose: 336 mg/kg/4 week- continuous Liver: Other changes

Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		NTIS** OTS0571374
oral
rat 		lowest published toxic dose: 1,638 mg/kg/13 week- continuous Liver: Other changes

Liver: Changes in liver weight

Endocrine: Changes in thyroid weight 		NTIS** OTS0571976
oral
rat 		lowest published toxic dose: 10,950 mg/kg/1 year- continuous Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0537614
oral
rat 		lowest published toxic dose: 60 mg/kg/6 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other 		TOXID9 78,228,2004
oral
rat 		lowest published toxic dose: 75 mg/kg/5 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		TOXID9 90,373,2006
oral
rat 		lowest published toxic dose: 173.7 mg/kg/90 day- continuous Liver: Changes in liver weight

Endocrine: Changes in thyroid weight

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation 		FEREAC 70,49599,2005
oral
rat 		lowest published toxic dose: 43.07 mg/kg/2 year- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Endocrine: Other changes 		FEREAC 70,49599,2005
oral
rat 		lowest published toxic dose: 56.94 mg/kg/2 year- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Endocrine: Other changes 		FEREAC 70,49599,2005
oral
rat 		lowest published toxic dose: 8,322 mg/kg/2 year- continuous Endocrine: Thyroid tumors

Tumorigenic: Tumor types after systemic administration not seen spontaneously 		FEREAC 70,49599,2005
skin
rabbit 		lowest published toxic dose: 280 mg/kg/28 day- intermittent Behavioral: Food intake (animal)

Skin: After topical application: Primary irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FEREAC 70,49599,2005
skin
rabbit 		lowest published toxic dose: 210 mg/kg/21 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FEREAC 72,46906,2007


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
ENTOX* -,334,2005
TOXICOLOGY REVIEW
TOXIA6 49,413,2007
TOXICOLOGY REVIEW
FEREAC 72,46906,2007
TOXICOLOGY REVIEW
FEREAC 72,46906,2007
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Active registration RBREV* -,370,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HTOPA*
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as insecticide

RTECS Compound Description:
   Agricultural Chemical
   Human Data

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