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Registry of Toxic Effects of Chemical Substances (RTECS)

1H-Pyrazole-3-carbonitrile, 5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-((trifluoromethyl)sulfinyl)-

RTECS #

UQ4430250

CAS #

120068-37-3

Updated

December 2013

Molecular Weight

437.16

Molecular Formula

C12H4Cl2F6N4OS

Synonyms

Fipronil
M & B 46030
Regent

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mammal (species unspecified) 390 mg/kg (6-22D preg/10D after birth)Reproductive: Effects on newborn: BehavioralFEREAC 63,38486,1998

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 25 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.NRTXDN 32,935,2011
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 50 µmol/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Apoptosis in vitro
NRTXDN 32,935,2011
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 50 µmol/L/6HIn Vitro Toxicity Studies: Apoptosis in vitroNRTXDN 32,935,2011
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 100 µmol/L/1HBiochemical: Metabolism (intermediary): Xanthine, purine or nucleotides including urate

Biochemical: Metabolism (intermediary): Glycolytic
NRTXDN 32,935,2011
inhalation/rat lethal concentration (50 percent kill): 0.39 gm/m3ENTOX* -,334,2005
oral/mammal (species unspecified) lethal dose (50 percent kill): 92 mg/kgFEREAC 63,38488,1998
oral/man lowest published lethal dose: 1.43 mL/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Skin and Appendages: Other: Sweating
JTCTDW 42,955,2004
oral/mouse lethal dose (50 percent kill): 95 mg/kgENTOX* -,334,2005
oral/rat lowest published toxic dose: 100 mg/kgBrain and Coverings: Changes in surface EEG

Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Change in motor activity (specific assay)
TXCYAC 214,67,2005
oral/rat lethal dose (50 percent kill): 97 mg/kgENTOX* -,334,2005
oral/wild bird lethal dose (50 percent kill): 1120 mg/kgENTOX* -,334,2005
skin/rabbit lethal dose (50 percent kill): 354 mg/kgENTOX* -,334,2005
skin/rat lethal dose (50 percent kill): >2 gm/kgENTOX* -,334,2005

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 910 mg/kg/13W- intermittentBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0555596
oral/mouse lowest published toxic dose: 288 mg/kg/90D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainFEREAC 70,49599,2005
oral/mouse lowest published toxic dose: 554 mg/kg/6W- continuousBehavioral: Irritability

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0555580
oral/rat lowest published toxic dose: 42 mg/kg/14D- intermittentLiver: Other changes

Endocrine: Evidence of thyroid hypofunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
TXCYAC 255,38,2009
oral/rat lowest published toxic dose: 75 mg/kg/5D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
TOXID9 -,440,2009
oral/rat lowest published toxic dose: 43.07 mg/kg/2Y- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Endocrine: Other changes
FEREAC 70,49599,2005
oral/rat lowest published toxic dose: 56.94 mg/kg/2Y- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Endocrine: Other changes
FEREAC 70,49599,2005
oral/rat lowest published toxic dose: 8322 mg/kg/2Y- continuousEndocrine: Thyroid tumors

Tumorigenic: Tumor types after systemic administration not seen spontaneously
FEREAC 70,49599,2005
oral/rat lowest published toxic dose: 60 mg/kg/6D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other
TOXID9 78,228,2004
oral/rat lowest published toxic dose: 75 mg/kg/5D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOXID9 90,373,2006
oral/rat lowest published toxic dose: 173.7 mg/kg/90D- continuousLiver: Changes in liver weight

Endocrine: Changes in thyroid weight

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
FEREAC 70,49599,2005
oral/rat lowest published toxic dose: 420 mg/kg/2W- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0571733
oral/rat lowest published toxic dose: 336 mg/kg/4W- continuousLiver: Other changes

Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
NTIS** OTS0571374
oral/rat lowest published toxic dose: 1638 mg/kg/13W- continuousLiver: Other changes

Liver: Changes in liver weight

Endocrine: Changes in thyroid weight
NTIS** OTS0571976
oral/rat lowest published toxic dose: 10950 mg/kg/1Y- continuousKidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0537614
skin/rabbit lowest published toxic dose: 210 mg/kg/21D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 72,46906,2007
skin/rabbit lowest published toxic dose: 280 mg/kg/28D- intermittentBehavioral: Food intake (animal)

Skin: After topical application: Primary irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 70,49599,2005

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWENTOX* -,334,2005
TOXICOLOGY REVIEWTOXIA6 49,413,2007
TOXICOLOGY REVIEWFEREAC 72,46906,2007
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWMUREAV 675,1,2009
TOXICOLOGY REVIEWFEREAC 74,15971,2009

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESActive registrationRBREV* -,370,1998

Status in Federal Agencies

OrganizationReference
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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