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Registry of Toxic Effects of Chemical Substances (RTECS)

Propylamine

RTECS #

UH9100000

CAS #

107-10-8

Updated

July 2011

Molecular Weight

59.13

Molecular Formula

C3H9N

Synonyms

1-Aminopropane
1-Propanamine
1-Propylamine
Mono-n-propylamine
Monopropylamine
n-Propylamine
Propanamine
RCRA waste number U194

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 720 µg severeUCDS** 8/12/1968
skin /rabbit 100 µg/24H open irritation testAIHAAP 23,95,1962

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 11 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 2500 mg/m3TPKVAL 14,80,1975
inhalation/mouse lethal concentration (50 percent kill): 2500 mg/m3/2H85GMAT -,102,1982
inhalation/rat lethal concentration (50 percent kill): 2310 ppm/4HLung, Thorax, or Respiration: Dyspnea

Liver: Hepatitis (hepatocellular necrosis), diffuse
AEHLAU 1,343,1960
intraperitoneal/rat lowest published lethal dose: 37500 µg/kgFATOAO 31,238,1968
oral/rat lethal dose (50 percent kill): 370 mg/kgNTIS** OTS0535430
skin/rabbit lethal dose (50 percent kill): 400 mg/kgNTIS** OTS0535430
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 580 mg/kgTPKVAL 14,80,1975

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 400 ppm/7H/50D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AEHLAU 1,343,1960

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWCHREAY 9,389,1931

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83632; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 28
National Occupational Hazard Survey 1974Hazard Code 83632; Number of Industries 3; Total Number of Facilities 339; Number of Occupations 7; Total Number of Employees Exposed 1723

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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