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Registry of Toxic Effects of Chemical Substances (RTECS)

Propionitrile, 2,2'-azobis(2-methyl-

RTECS #

UG0800000

CAS #

78-67-1

Updated

November 2009

Molecular Weight

164.24

Molecular Formula

C8H12N4

Synonyms

2,2'-Azobis(2-methylpropionitrile)
2,2'-Azobis(isobutyronitrile)
2,2'-Azodiisobutyronitrile
2,2'-Dicyano-2,2'-azopropane
Aceto AZIB
AIBN
alpha,alpha'-Azobisisobutylonitrile
alpha,alpha'-Azodiisobutyronitrile
Azobisisobutylonitrile
Azobisisobutyronitrile
Poly-Zole AZDN
Porofor 57
Porophor N
VAZO 64

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 6%HPV147 -,-,2002

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1950 mg/kg (14D pre-3D after birth)Reproductive: Other effects on female

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
HPV147 -,-,2002

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lethal concentration: >12 gm/m3/4HEye: Conjunctiva irritation

Behavioral: Excitement

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0555369
inhalation/rat lethal concentration (50 percent kill): >7780 mg/m3/1HSkin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV147 -,-,2002
intraperitoneal/mouse lethal dose (50 percent kill): 25 mg/kgNTIS** AD691-490
intraperitoneal/rat lethal dose (50 percent kill): 25 mg/kgBehavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
NTIS** OTS0555369
oral/mouse lethal dose (50 percent kill): 700 mg/kg85KYAH 11,146,1989
oral/rat lethal dose (50 percent kill): 100 mg/kgBehavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
NTIS** OTS0555369
oral/rat lethal dose (50 percent kill): 360 mg/kgLung, Thorax, or Respiration: Other changes

Liver: Other changes

Blood: Hemorrhage
HPV147 -,-,2002
skin/rabbit lowest published lethal dose: 7940 mg/kgLung, Thorax, or Respiration: Other changes

Liver: Other changes

Blood: Hemorrhage
HPV147 -,-,2002
subcutaneous/guinea pig lowest published lethal dose: 50 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes
ATXKA8 16,367,1957
subcutaneous/mouse lowest published lethal dose: 40 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes
ATXKA8 16,367,1957
subcutaneous/rabbit lowest published lethal dose: 50 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes
ATXKA8 16,367,1957
subcutaneous/rat lowest published lethal dose: 30 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes
ATXKA8 16,367,1957

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 80 mg/m3/4D- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV147 -,-,2002
inhalation/rat lowest published toxic concentration: 80 mg/m3/4D- intermittentLiver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV147 -,-,2002
inhalation/rat lowest published toxic concentration: 10 mg/m3/10D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
HPV147 -,-,2002
oral/Dog lowest published toxic dose: 675 mg/kg/90D- intermittentLiver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
HPV147 -,-,2002
oral/Dog lowest published toxic dose: 700 mg/kg/28D- intermittentLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV147 -,-,2002
oral/rat lowest published toxic dose: 2200 mg/kg/11D- continuousGastrointestinal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0555369
oral/rat lowest published toxic dose: 420 mg/kg/42D- intermittentGastrointestinal: Changes in structure or function of salivary glands

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
HPV147 -,-,2002
oral/rat lowest published toxic dose: 390 mg/kg/39D- intermittentLiver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV147 -,-,2002
oral/rat lowest published toxic dose: 1950 mg/kg/39D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV147 -,-,2002

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84048; Number of Industries 7; Total Number of Facilities 89; Number of Occupations 21; Total Number of Employees Exposed 4313; Total Number of Female Employees Exposed 116
National Occupational Hazard Survey 1974Hazard Code 84048; Number of Industries 4; Total Number of Facilities 63; Number of Occupations 7; Total Number of Employees Exposed 640

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8909
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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