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Propionitrile, 2 - ( (4 - chloro - 6 - (ethylamino) - s - triazin - 2 - yl) amino) - 2 - methyl -

RTECS #: UG1490000

CAS #: 21725-46-2


UPDATE: May 2009 MW: 240.73 MF: C9H13ClN6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - ( (4 - Chloro - 6 - (ethylamino) - s - triazin - 2 - yl) amino) - 2 - methylpropionitrile
  2. 2 - (4 - Chloro - 6 - ethylamino - 1,3,5 - triazine - 2 - ylamino) - 2 - methylpropionitrile
  3. 2 - (4 - Chloro - 6 - ethylamino - s - triazine - 2 - ylamino) - 2 - methyl - propionitrile
  4. 2 - Chloro - 4 - (1 - cyano - 1 - methylethylamino) - 6 - ethylamino - 1,3,5 - triazine
  5. Bladex
  6. Bladex 80WP
  7. Blanchol
  8. Cyanazine
  1. DW3418
  2. Fortrol
  3. Payze
  4. Propanenitrile, 2 - ( (4 - Chloro - 6 - (ethylamino) - 1,3,5 - triazin - 2 - yl) amino) - 2 - methyl -
  5. Propanenitrile, 2 - ( (4 - chloro - 6 - (ethylamino) - 1,3,5 - triazin - 2 - yl) amino) - 2 - methyl -
  6. SD 15418
  7. WL 19805
  8. s - Triazine, 2 - chloro - 4 - ethylamino - 6 - (1 - cyano - 1 - methyl) ethylamino -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis human lymphocyte 1 mg/L MUREAV 281,295,1992
dominant lethal test parenteral
Drosophila melanogaster
332 Ámol/L JTEHD6 3,691,1977
dominant lethal test oral
Drosophila melanogaster
100 ppm JTEHD6 3,691,1977
DNA damage intraperitoneal
mouse
300 mg/kg MUREAV 493,1,2001
morphological transform mouse fibroblast 50 mg/L EMMUEG 21,81,1993


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 250 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 25(2),59A,1982
oral
rat
lowest published toxic dose: 63 mg/kg (6-19 day pregnant) Reproductive: Other effects on female NNGADV 11,127,1986
oral
rat
lowest published toxic dose: 250 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear RTOPDW 29,88,1999
oral
rat
lowest published toxic dose: 1,612.8 mg/kg (72 day male/72 day prior to copulation) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) HBPTO* 1,714,2001
oral
rat
lowest published toxic dose: 2,692.8 mg/kg (72 day male/72 day prior to copulation) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
HBPTO* 1,714,2001
oral
rat
lowest published toxic dose: 11.2 mg/kg (multigenerations) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
HBPTO* 1,714,2001
oral
rabbit
lowest published toxic dose: 52 mg/kg (6-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Eye, ear
RTOPDW 29,88,1999


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 910 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
JTEHF8 60,567,2000
oral
rat
lowest published toxic dose: 1,825 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Other reproductive system tumors
HBPTO* 2,1514,2001


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 2,470 mg/m3/4 hour N/R NNGADV 11,127,1986
inhalation
rat
lowest published lethal concentration: >4,900 mg/m3 Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
PSSCBG 5,153,1974
inhalation
rat
lethal concentration (50 percent kill): >960 mg/m3/4 hour N/R HBPTO* 1,709,2001
inhalation
rat
lethal concentration (50 percent kill): 906 mg/m3 Gastrointestinal: Nausea or vomiting HBPTO* 1,709,2001
intraperitoneal
mouse
lethal dose (50 percent kill): 174 mg/kg N/R NNGADV 11,127,1986
intraperitoneal
rat
lethal dose (50 percent kill): 112 mg/kg N/R NNGADV 11,127,1986
oral
chicken
lethal dose (50 percent kill): 750 mg/kg Ear: Change in acuity

Behavioral: Somnolence (general depressed activity)
PSSCBG 5,153,1974
oral
duck
lethal dose (50 percent kill): >2 gm/kg N/R PEMNDP 9,192,1991
oral
dog
lowest published toxic dose: 5 mg/kg Endocrine: Adrenal cortex hypoplasia HBPTO* 1,710,2001
oral
mouse
lethal dose (50 percent kill): 380 mg/kg N/R 28ZEAL 5,62,1976
oral
quail
lethal dose (50 percent kill): 400 mg/kg N/R PEMNDP 9,192,1991
oral
rat
lethal dose (50 percent kill): 149 mg/kg N/R 85ARAE 2,132,1977
oral
rabbit
lethal dose (50 percent kill): 141 mg/kg N/R 85DPAN -,-,1971/1976
subcutaneous
mouse
lethal dose (50 percent kill): 3,715 mg/kg N/R NNGADV 11,127,1986
subcutaneous
rat
lethal dose (50 percent kill): 1,738 mg/kg N/R NNGADV 11,127,1986
skin
mouse
lethal dose (50 percent kill): >6,590 mg/kg N/R NNGADV 11,127,1986
skin
rat
lethal dose (50 percent kill): 1,200 mg/kg N/R 28ZEAL 5,62,1976
skin
rabbit
lethal dose (50 percent kill): >2 gm/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
PSSCBG 5,153,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 1,365 mg/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NNGADV 11,127,1986
oral
dog
lowest published toxic dose: 3,650 mg/kg/2 year- continuous Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NNGADV 11,127,1986
oral
dog
lowest published toxic dose: 912.5 mg/kg/2 year- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 1,710,2001
oral
dog
lowest published toxic dose: 1,095 mg/kg/1 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 1,710,2001
oral
dog
lowest published toxic dose: 2,044 mg/kg/1 year- continuous Cardiac: Changes in heart weight

Liver: Changes in liver weight

Endocrine: Changes in adrenal weight
HBPTO* 1,710,2001
oral
dog
lowest published toxic dose: 1,022 mg/kg/1 year- continuous Lung, Thorax, or Respiration: Changes in lung weight

Kidney, Ureter, and Bladder: Changes in kidney weight
HBPTO* 1,710,2001
oral
dog
lowest published toxic dose: 2,730 mg/kg/52 week- intermittent Blood: Other changes HBPTO* 2,1512,2001
oral
mouse
lowest published toxic dose: 6,825 mg/kg/13 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 1,710,2001
oral
mouse
lowest published toxic dose: 1,095 mg/kg/2 year- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 1,710,2001
oral
mouse
lowest published toxic dose: 27,375 mg/kg/2 year- continuous Endocrine: Hypoglycemia

Skin and Appendages: Other: Hair

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
HBPTO* 1,710,2001
oral
mouse
lowest published toxic dose: 109,500 mg/kg/2 year- continuous Cardiac: Cardiomyopathy including infarction

Skin: After systemic exposure: Dermatitis, other
HBPTO* 1,710,2001
oral
mouse
lowest published toxic dose: 27,375 mg/kg/2 year- continuous Cardiac: Cardiomyopathy including infarction

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
HBPTO* 1,710,2001
oral
mouse
lowest published toxic dose: 1,970 mg/kg/78 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1514,2001
oral
rat
lowest published toxic dose: 273 mg/kg/13 week- continuous Behavioral: Food intake (animal)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NNGADV 11,127,1986
oral
rat
lowest published toxic dose: 365.4 mg/kg/371 day- continuous Behavioral: Food intake (animal)

Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy)

Tumorigenic: Carcinogenic by RTECS criteria
JTEHD6 60,567,2000
oral
rat
lowest published toxic dose: 508.3 mg/kg/371 day- continuous Behavioral: Food intake (animal) JTEHD6 60,567,2000
oral
rat
lowest published toxic dose: 730 mg/kg/2 year- continuous Behavioral: Excitement

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 1,710,2001
oral
rat
lowest published toxic dose: 73,000 mg/kg/2 year- continuous Endocrine: Tumors

Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy)
HBPTO* 1,710,2001
oral
rat
lowest published toxic dose: 1,346.4 mg/kg/72 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 1,714,2001
oral
rat
lowest published toxic dose: 146,000 mg/kg/2 year- continuous Related to Chronic Data: Changes in testicular weight HBPTO* 1,714,2001
oral
rat
lowest published toxic dose: 1,350 mg/kg/90 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1512,2001
oral
rat
lowest published toxic dose: 730 mg/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1514,2001
oral
rat
lowest published toxic dose: 730 mg/kg/2 year- continuous Behavioral: Euphoria HBPTO* 2,1514,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,106,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: D melanogaster-whole sex chrom. loss; N crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-nondisjunction
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-partial sex chrom. loss
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
Used for preemergence or postemergence weed control in field corn
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HTOPA*
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
PSSCBG Pesticide Science. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1970-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RTOPDW Regulatory Toxicology and Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-

Used for preemergence or postemergence weed control in field corn

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Natural Product

ALT CAS #: 11096-88-1
Click Here for Additional Information about RTECS

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