Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Propionitrile, 2-((4-chloro-6-(ethylamino)-s-triazin-2-yl)amino)-2-methyl-

RTECS #

UG1490000

CAS #

21725-46-2; 11096-88-1

Updated

April 2012

Molecular Weight

240.73

Molecular Formula

C9H13ClN6

Synonyms

2-((4-Chloro-6-(ethylamino)-s-triazin-2-yl)amino)-2-methylpropionitrile
2-(4-Chloro-6-ethylamino-1,3,5-triazine-2-ylamino)-2-methylpropionitrile
2-(4-Chloro-6-ethylamino-s-triazine-2-ylamino)-2-methyl-propionitrile
2-Chloro-4-(1-cyano-1-methylethylamino)-6-ethylamino-1,3,5-triazine
Bladex
Bladex 80WP
Blanchol
Cyanazine
DW3418
Fortrol
Payze
Propanenitrile, 2-((4-Chloro-6-(ethylamino)-1,3,5-triazin-2-yl)amino)-2-methyl-
Propanenitrile, 2-((4-chloro-6-(ethylamino)-1,3,5-triazin-2-yl)amino)-2-methyl-
SD 15418
s-Triazine, 2-chloro-4-ethylamino-6-(1-cyano-1-methyl)ethylamino-
WL 19805

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human1 mg/LMUREAV 281,295,1992
DNA Damageintraperitoneal/mouse300 mg/kgMUREAV 493,1,2001
Dominant Lethal Testparenteral/Drosophila melanogaster332 µmol/LJTEHD6 3,691,1977
Dominant Lethal Testoral/Drosophila melanogaster100 ppmJTEHD6 3,691,1977
morphological transformfibroblast/mouse50 mg/LEMMUEG 21,81,1993

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 250 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTJADAB 25(2),59A,1982
oral/rat 63 mg/kg (6-19D pregnant)Reproductive: Other effects on femaleNNGADV 11,127,1986
oral/rat 250 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Eye, earRTOPDW 29,88,1999
oral/rabbit 52 mg/kg (6-18D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Eye, ear
RTOPDW 29,88,1999
oral/rat 1612.8 mg/kg (72D male/72D prior to copulation)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)HBPTO* 1,714,2001
oral/rat 2692.8 mg/kg (72D male/72D prior to copulation)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
HBPTO* 1,714,2001
oral/rat 11.2 mg/kg (multigenerations)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
HBPTO* 1,714,2001

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 910 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
JTEHF8 60,567,2000
oral/rat lowest published toxic dose: 1825 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Reproductive: Other reproductive system tumors
HBPTO* 2,1514,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 2470 mg/m3/4HNNGADV 11,127,1986
inhalation/rat lethal concentration (50 percent kill): >960 mg/m3/4HHBPTO* 1,709,2001
inhalation/rat lethal concentration (50 percent kill): 906 mg/m3Gastrointestinal: Nausea or vomitingHBPTO* 1,709,2001
inhalation/rat Lethal concentration: >4900 mg/m3Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
PSSCBG 5,153,1974
intraperitoneal/mouse lethal dose (50 percent kill): 174 mg/kgNNGADV 11,127,1986
intraperitoneal/rat lethal dose (50 percent kill): 112 mg/kgNNGADV 11,127,1986
oral/chicken lethal dose (50 percent kill): 750 mg/kgEar: Change in acuity

Behavioral: Somnolence (general depressed activity)
PSSCBG 5,153,1974
oral/Dog lowest published toxic dose: 5 mg/kgEndocrine: Adrenal cortex hypoplasiaHBPTO* 1,710,2001
oral/duck lethal dose (50 percent kill): >2 gm/kgPEMNDP 9,192,1991
oral/mouse lethal dose (50 percent kill): 380 mg/kg28ZEAL 5,62,1976
oral/quail lethal dose (50 percent kill): 400 mg/kgPEMNDP 9,192,1991
oral/rabbit lethal dose (50 percent kill): 141 mg/kg85DPAN -,-,1971/1976
oral/rat lethal dose (50 percent kill): 149 mg/kg85ARAE 2,132,1977
skin/mouse lethal dose (50 percent kill): >6590 mg/kgNNGADV 11,127,1986
skin/rabbit lethal dose (50 percent kill): >2 gm/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
PSSCBG 5,153,1974
skin/rat lethal dose (50 percent kill): 1200 mg/kg28ZEAL 5,62,1976
subcutaneous/mouse lethal dose (50 percent kill): 3715 mg/kgNNGADV 11,127,1986
subcutaneous/rat lethal dose (50 percent kill): 1738 mg/kgNNGADV 11,127,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 1365 mg/kg/13W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NNGADV 11,127,1986
oral/Dog lowest published toxic dose: 3650 mg/kg/2Y- continuousLiver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NNGADV 11,127,1986
oral/Dog lowest published toxic dose: 912.5 mg/kg/2Y- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 1,710,2001
oral/Dog lowest published toxic dose: 1095 mg/kg/1Y- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 1,710,2001
oral/Dog lowest published toxic dose: 2730 mg/kg/52W- intermittentBlood: Other changesHBPTO* 2,1512,2001
oral/Dog lowest published toxic dose: 2044 mg/kg/1Y- continuousCardiac: Changes in heart weight

Liver: Changes in liver weight

Endocrine: Changes in adrenal weight
HBPTO* 1,710,2001
oral/Dog lowest published toxic dose: 1022 mg/kg/1Y- continuousLung, Thorax, or Respiration: Changes in lung weight

Kidney, Ureter, and Bladder: Changes in kidney weight
HBPTO* 1,710,2001
oral/mouse lowest published toxic dose: 1970 mg/kg/78W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1514,2001
oral/mouse lowest published toxic dose: 6825 mg/kg/13W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 1,710,2001
oral/mouse lowest published toxic dose: 27375 mg/kg/2Y- continuousEndocrine: Hypoglycemia

Skin and Appendages: Other: Hair

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
HBPTO* 1,710,2001
oral/mouse lowest published toxic dose: 109500 mg/kg/2Y- continuousCardiac: Cardiomyopathy including infarction

Skin: After systemic exposure: Dermatitis, other
HBPTO* 1,710,2001
oral/mouse lowest published toxic dose: 27375 mg/kg/2Y- continuousCardiac: Cardiomyopathy including infarction

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
HBPTO* 1,710,2001
oral/mouse lowest published toxic dose: 1095 mg/kg/2Y- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 1,710,2001
oral/rat lowest published toxic dose: 730 mg/kg/2Y- continuousBehavioral: Excitement

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 1,710,2001
oral/rat lowest published toxic dose: 73000 mg/kg/2Y- continuousEndocrine: Tumors

Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy)
HBPTO* 1,710,2001
oral/rat lowest published toxic dose: 1346.4 mg/kg/72D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 1,714,2001
oral/rat lowest published toxic dose: 146000 mg/kg/2Y- continuousRelated to Chronic Data: Changes in testicular weightHBPTO* 1,714,2001
oral/rat lowest published toxic dose: 365.4 mg/kg/371D- continuousBehavioral: Food intake (animal)

Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy)

Tumorigenic: Carcinogenic by RTECS criteria
JTEHD6 60,567,2000
oral/rat lowest published toxic dose: 508.3 mg/kg/371D- continuousBehavioral: Food intake (animal)JTEHD6 60,567,2000
oral/rat lowest published toxic dose: 273 mg/kg/13W- continuousBehavioral: Food intake (animal)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NNGADV 11,127,1986
oral/rat lowest published toxic dose: 730 mg/kg/2Y- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1514,2001
oral/rat lowest published toxic dose: 730 mg/kg/2Y- continuousBehavioral: EuphoriaHBPTO* 2,1514,2001
oral/rat lowest published toxic dose: 1350 mg/kg/90D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1512,2001

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWMUTAEX 26,19,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,106,1998

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-nondisjunction
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-partial sex chrom. loss
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-whole sex chrom. loss; N crassa-aneuploidy
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
TOP