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Registry of Toxic Effects of Chemical Substances (RTECS)

Propionic acid, 2-(2,4-dichlorophenoxy)-

RTECS #

UF1050000

CAS #

120-36-5

Updated

August 2007

Molecular Weight

235.07

Molecular Formula

C9H8Cl2O3

Synonyms

2-(2,4-Dichloor-fenoxy)-propionzuur (Dutch)
2-(2,4-Dichlorophenoxy) propionic acid
2-(2,4-Dichlor-phenoxy)-propionsaeure (German)
2,4-DP
Acide 2-(2,4-dichloro-phenoxy) propionique (French)
Acido 2-(2,4-dicloro-fenossi)-propionico (Italian)
alpha-(2,4-Dichlorophenoxy) propionic acid
BH 2,4-DP
Canapur DP
Cornox RK
Cornoxynil
Dichloroprop
Dichlorprop
Hedonal DP
Herbizid DP
Kildip
Kwas 2,4-dwuchlorofenoksypropionowy (Polish)
Kyselina 2-(2,4-dichlorfenoxy)propionova (Czech)
Mayclene
Propanoic acid, 2-(2,4-dichlorophenoxy)-
Seritox 50
U46 DP-Fluid
Weedone 170

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Saccharomyes cerevisiae700 mg/L (-enzymatic activation step)ZAPOAK 9,483,1969

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 20 mg/kg (4-18D pregnant)Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Physical
TJADAB 33,11A,1986
oral/mouse 5 gm/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
ARZNAD 33,1479,1983
oral/mouse 3 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)ARZNAD 33,1479,1983
oral/mouse 4 gm/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemARZNAD 33,1479,1983
oral/mouse 20 mg/kg (4-18D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TJADAB 33,11A,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lethal concentration: >1600 mg/m3Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity
GTPZAB 27(9),50,1983
oral/guinea pig lethal dose (50 percent kill): 620 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity

Behavioral: Coma
GISAAA 50(9),22,1985
oral/mouse lethal dose (50 percent kill): 309 mg/kgRPZHAW 31,373,1980
oral/rat lethal dose (50 percent kill): 344 mg/kgATDAEI 1,177,1992
skin/mouse lethal dose (50 percent kill): 1400 mg/kg28ZEAL 5,76,1976
skin/rat lethal dose (50 percent kill): 1880 mg/kgBehavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Body temperature decrease
GISAAA 50(9),22,1985
subcutaneous/mouse lethal dose (50 percent kill): 1400 mg/kg85JCAE -,547,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 100 mg/m3/17W- continuousKidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
GTPZAB 27(9),50,1983
oral/rat lowest published toxic dose: 6188 mg/kg/17W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldGISAAA 50(9),22,1985
oral/rat lowest published toxic dose: 1893 mg/kg/1Y- intermittentLiver: Changes in liver weight

Endocrine: Hypoglycemia

Nutritional and Gross Metabolic: Changes in: Na
GISAAA 50(9),22,1985
skin/rabbit lowest published toxic dose: 4500 mg/kg/30D- intermittentSkin: After systemic exposure: Dermatitis, other

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GISAAA 50(9),22,1985

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 41,357,1986
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMSUDL 7,156,1987
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWJTCTDW 38,111,2000
TOXICOLOGY REVIEWENTOX* -,569,2005

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESUnsupportedRBREV* -,74,1998

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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