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Registry of Toxic Effects of Chemical Substances (RTECS)

Propionic acid, 2-((4-chloro-o-tolyl)oxy)-

RTECS #

UE9750000

CAS #

93-65-2; 7085-19-0

Updated

August 2007

Molecular Weight

214.66

Molecular Formula

C10H11ClO3

Synonyms

2-(2-Methyl-4-chlorphenoxy)-propionsaeure (German)
2-(4-Chloor-2-methyl-fenoxy)-propionzuur (Dutch)
2-(4-Chlor-2-methyl-phenoxy)-propionsaeure (German)
2-(4-Chloro-2-methylphenoxy)propanoic acid
2-(p-Chloro-o-tolyloxy)propionic acid
2M 4KhP
2M-4CP
2-Methyl-4-chlorophenoxy-alpha-propionic acid
4-Chloro-2-methylphenoxy-alpha-propionic acid
Acide 2-(4-chloro-2-methyl-phenoxy)propionique (French)
Acido 2-(4-cloro-2-metil-fenossi)-propionico (Italian)
alpha-(2-Methyl-4-chlorophenoxy)propionic acid
alpha-(4-Chloro-2-methylphenoxy)propionic acid
Anicon B
Anicon P
Celatox CMPP
CMPP
Compitox
FBC CMPP
Isocarnox
Kilprop
Kwas 4-chloro-2-metylofenoksypropionowy (Polish)
Kyselina 2-(4-chlor-2-methylfenoxy)propionova (Czech)
Liranox
MCPP
Mechlorprop
Mecomec
Mecoprop
Mecoturf
Morogal
Okultin MP
Propanoic acid, 2-(4-chloro-2-methylphenoxy)-
Proponex-plus
Rankotex
SYS 67 Mecmin
U 46 KV Fluid

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionoral/mouse100 mg/kgMUREAV 55,197,1978
gene conversion and mitotic recombination/Saccharomyes cerevisiae742 ppmMUREAV 21,83,1973

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 7 gm/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
ARZNAD 33,1479,1983
oral/mouse 3 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)ARZNAD 33,1479,1983
oral/mouse 5 gm/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)ARZNAD 33,1479,1983

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lethal dose (50 percent kill): 402 mg/kgTXCYAC 3,349,1975
oral/mouse lethal dose (50 percent kill): 369 mg/kgRPZHAW 31,373,1980
oral/rat lethal dose (50 percent kill): 650 mg/kgWRPCA2 9,119,1970
skin/rabbit lethal dose (50 percent kill): 900 mg/kgPCOC** -,683,1966
unreported route/mouse lethal dose (50 percent kill): 650 mg/kg30ZDA9 -,173,1971
unreported route/quail lethal dose (50 percent kill): >500 mg/kgFMCHA2 -,C193,1991

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 14400 mg/kg/90D- intermittentBehavioral: Food intake (animal)

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 3,349,1975
skin/rabbit lowest published toxic dose: 15 gm/kg/3W- intermittentSkin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXCYAC 3,349,1975

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 41,357,1986
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMSUDL 7,156,1987
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWJTCTDW 38,111,2000
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,569,2005

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESUnsupportedRBREV* -,127,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M4007; Number of Industries 1; Total Number of Facilities 263; Number of Occupations 1; Total Number of Employees Exposed 1578
National Occupational Hazard Survey 1974Hazard Code M4007; Number of Industries 2; Total Number of Facilities 40; Number of Occupations 2; Total Number of Employees Exposed 104

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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