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Registry of Toxic Effects of Chemical Substances (RTECS)

Propionic acid, 2-chloro-

RTECS #

UE8575000

CAS #

598-78-7

Updated

September 201

Molecular Weight

108.53

Molecular Formula

C3H5ClO2

Synonyms

2-Chloropropionic acid
2-Chloropropionic acid (ACGIH)
Propanoic acid, 2-chloro- (9CI)
Propionic acid, alpha-chloro-

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/mouse lethal dose (50 percent kill): 400 mg/kgBehavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Hematuria

Skin and Appendages: Other: Hair
NTIS** OTS0555355
oral/rat lethal dose (50 percent kill): 800 mg/kgBehavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Hematuria

Skin and Appendages: Other: Hair
NTIS** OTS0555355
skin/guinea pig lethal dose (50 percent kill): 126 mg/kg85INA8 5,136(89),1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 7182 mg/kg/42D- continuousGastrointestinal: Changes in structure or function of esophagus

Skin and Appendages: Other: Hair

Related to Chronic Data: Changes in testicular weight
NTIS** OTS0555355

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 ppm (skin)DTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 ppm (0.44 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 ppm (0.44 mg/m3);KZW 0.2 ppm (0.88 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 ppm (0.45 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 ppm (0.44 mg/m3), skin, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 ppm (0.44 mg/m3), skin, NOV2011
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 ppm (0.44 mg/m3), skin, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0.1 ppm (0.44 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, Skin, JUN2003
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.44 mg/m3, Skin, 2003

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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