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Registry of Toxic Effects of Chemical Substances (RTECS)

Propionic acid, butyl ester

RTECS #

UE8245000

CAS #

590-01-2

Updated

April 2010

Molecular Weight

130.21

Molecular Formula

C7H14O2

Synonyms

Butyl propanoate
Butyl propionate
n-Butyl propionate
Propanoic acid, butyl ester (9CI)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg severeATDAEI 1,192,1992
eye /rabbit 0.1 mL moderateHPV310 -,-,2003
skin /guinea pig 0.3 mL mildHPV310 -,-,2003
skin /rabbit 500 mg/24H moderateFCTXAV 18,661,1980
skin /rabbit 0.5 mL mildHPV310 -,-,2003

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 500 ppm (6-15D pregnant)Reproductive: Other effects on femaleHPV310 -,-,2003

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >3800 ppm/6HHPV310 -,-,2003
oral/rat lethal dose (50 percent kill): 11031 mg/kgEye: Lacrimation

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes
HPV310 -,-,2003
oral/rat lethal dose (50 percent kill): >5000 mg/kgHPV310 -,-,2003
skin/rabbit lethal dose (50 percent kill): >14008 mg/kgSkin: After topical application: Primary irritationHPV310 -,-,2003
skin/rabbit lethal dose (50 percent kill): >14 gm/kgATDAEI 1,192,1992
skin/rat lethal dose (50 percent kill): >2000 mg/kgHPV310 -,-,2003

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 3200 ppm/6H/11D- intermittentOlfaction: Change in olfactory nerve

Behavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Other changes in urine composition
NTIS** OTS0557952
inhalation/rat lowest published toxic concentration: 1500 ppm/13W- intermittentOlfaction: Change in sensation of smell

Olfaction: Other olfaction effects
TOPADD 27,618,1999
inhalation/rat lowest published toxic concentration: 800 ppm/2W- intermittentBehavioral: Food intake (animal)

Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTEHF8 61,79,2000
inhalation/rat lowest published toxic concentration: 1500 ppm/6H/1W- intermittentBehavioral: Food intake (animal)JTEHD6 61,79,2000
inhalation/rat lowest published toxic concentration: 750 ppm/6H/4W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)JTEHD6 61,79,2000
inhalation/rat lowest published toxic concentration: 750 ppm/6H/13W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Olfaction: Other olfaction effects
JTEHD6 61,79,2000
inhalation/rat lowest published toxic concentration: 750 ppm/6H/13W- intermittentOlfaction: Other olfaction effectsJTEHD6 61,79,2000
inhalation/rat lowest published toxic concentration: 1000 ppm/6H/10D- intermittentEye: Lacrimation

Ear: Tumors
JTEHD6 61,79,2000
inhalation/rat lowest published toxic concentration: 2000 ppm/6H/10D- intermittentMusculoskeletal: Other changesJTEHD6 61,79,2000
inhalation/rat lowest published toxic concentration: 500 ppm/6H/10D- intermittentBehavioral: Food intake (animal)JTEHD6 61,79,2000
inhalation/rat lowest published toxic concentration: 750 ppm/13W- continuousOlfaction: Other olfaction effects

Blood: Change in clotting factors
HPV310 -,,2003
inhalation/rat lowest published toxic concentration: 2500 ppm/2W- continuousOlfaction: Other olfaction effects

Behavioral: Food intake (animal)

Gastrointestinal: Changes in structure or function of salivary glands
HPV310 -,,2003
inhalation/rat lowest published toxic concentration: 800 ppm/11D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV310 -,,2003
inhalation/rat lowest published toxic concentration: 1600 ppm/11D- continuousOlfaction: Other olfaction effects

Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV310 -,,2003

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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