Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Propionaldehyde

RTECS #

UE0350000

CAS #

123-38-6

Updated

September 201

Molecular Weight

58.09

Molecular Formula

C3H6O

Synonyms

Aldehyde propionique (French)
Methylacetaldehyde
NCI-C61029
Propaldehyde
Propanal
Propionic aldehyde
Propyl aldehyde
Propylic aldehyde

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 41 mg severeUCDS** 4/25/1958
eye /rabbit 20 mg/24H moderate85JCAE -,268,1986
skin /rabbit 500 mg open irritation test mildUCDS** 4/25/1958

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagelymphocyte/mammal (species unspecified)100 mmol/LMUREAV 283,131,1992
mutation in mammalian somatic cellslung/hamster10 mmol/LMUTAEX 4,277,1989
Unscheduled DNA Synthesisliver/rat30 µmol/LMUREAV 323,121,1994

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 21800 mg/m3GTPZAB 12(7),16,1968
inhalation/mouse lethal concentration (50 percent kill): 21800 mg/m3/2HLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,370,1984
inhalation/mouse lowest published toxic concentration: 10000 mg/m3Eye: Conjunctiva irritation

Behavioral: General anesthetic

Lung, Thorax, or Respiration: Dyspnea
VCVGK* -,370,1984
inhalation/mouse lethal concentration (50 percent kill): 21800 mg/m3/2H85GMAT -,102,1982
inhalation/rat Lowest published lethal concentration: 8000 ppm/4HAMIHBC 4,119,1951
inhalation/rat lowest published toxic concentration: 600 mg/m3/10MEye: Conjunctiva irritation

Behavioral: General anesthetic

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,370,1984
inhalation/rat lowest published toxic concentration: 4 mg/m3/4HBlood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
VCVGK* -,371,1984
intraperitoneal/mouse lethal dose (50 percent kill): 200 mg/kgBehavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
NTIS** OTS0533450
intraperitoneal/rat lethal dose (50 percent kill): 200 mg/kgBehavioral: General anesthetic

Behavioral: Muscle weakness
NTIS** OTS0533450
oral/mammal (species unspecified) lethal dose (50 percent kill): 1400 mg/kgGTPZAB 32(10),25,1988
oral/mouse lowest published lethal dose: 800 mg/kgKODAK* 21MAY1971
oral/rat lethal dose (50 percent kill): 1410 mg/kgAMIHBC 4,119,1951
oral/rat lethal dose (50 percent kill): 1410 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,370,1984
skin/guinea pig lethal dose (50 percent kill): 10 mL/kgSkin: After systemic exposure: Dermatitis, otherNTIS** OTS0533450
skin/rabbit lethal dose (50 percent kill): 2460 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
NTIS** OTS0543436
subcutaneous/mouse lethal dose (50 percent kill): 680 mg/kgBehavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold
APTOA6 6,299,1950
subcutaneous/rat lethal dose (50 percent kill): 820 mg/kgBehavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold
APTOA6 6,299,1950
unreported route/mouse lethal dose (50 percent kill): 800 mg/kgHBPTO* 1,825,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 4 mg/m3/24H/75D- continuousBrain and Coverings: Recordings from specific areas of CNS

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 47(4),10,1982
inhalation/rat lowest published toxic concentration: 23 mg/m3/3W- intermittentLung, Thorax, or Respiration: Emphysema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,371,1994

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 20 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-BELGIUMtime-weighted average 20 ppm (48 mg/m3), MAR2002
Occupational Exposure Limit-FINLANDtime-weighted average 20 ppm (48 mg/m3), NOV2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84709; Number of Industries 2; Total Number of Facilities 25; Number of Occupations 16; Total Number of Employees Exposed 2086; Total Number of Female Employees Exposed 187
National Occupational Hazard Survey 1974Hazard Code 84709; Number of Industries 2; Total Number of Facilities 80; Number of Occupations 4; Total Number of Employees Exposed 1543

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Aldehydes, screening, 2539
NIOSH CURRENT INTELLIGENCE BULLETIN #55, September 1991
On EPA IRIS database
TOP