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Registry of Toxic Effects of Chemical Substances (RTECS)

Propionanilide, 3',4'-dichloro-

RTECS #

UE4900000

CAS #

709-98-8; 11096-32-5

Updated

May 2009

Molecular Weight

218.09

Molecular Formula

C9H9Cl2NO

Synonyms

3,4-Dichloranilid kyseliny propionove (Czech)
3',4'-Dichlorophenylpropionanilide
3',4'-Dichloropropionanilide
3,4-Dichloropropionanilide
BAY 30130
Cekupropanil
Chem Rice
Crystal propanil-4
DCPA
Dichloropropionanilide
Dipram
DPA
Farmco propanil
FW 734
Grascide
Herbax technical
Montrose propanil
N-(3,4-Dichlorophenyl)propanamide
N-(3,4-Dichlorophenyl)propionamide
Propanamide, N-(3,4-dichlorophenyl)-
Propanex
Propanid
Propanide
Propanil
Propionic acid 3,4-dichloroanilide
Prop-Job
Riselect
Rogue
Rosanil
S 10165
Stam
Stam F 34
Stam LV 10
Stam M-4
Stam supernox
Stampede
Stampede 3E
Strel
Surcopur
Synpran N

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/mouse100 mg/kgCYGEDX 14(6),38,1980
DNA repair/Bacillus subtilis100 µg/discNTIS** PB80-133226
specific locus test/Drosophila melanogaster0.5 mmol/LEMMUEG 36,40,2000

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mammal (species unspecified) lowest published toxic dose: 50 mg/kgEndocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
HBPTO* 1,777,2001
intraperitoneal/mouse lowest published toxic dose: 50 mg/kgSpinal Cord: DemyelinationTOXID9 66,321,2002
oral/Dog lethal dose (50 percent kill): 1217 mg/kgBrain and Coverings: Recordings from specific areas of CNSTXAPA9 23,650,1972
oral/mammal (species unspecified) lethal dose (50 percent kill): 2527 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
NTIS** PB288-416
oral/mouse lethal dose (50 percent kill): 360 mg/kgGTPZAB 21(12),30,1977
oral/rat lethal dose (50 percent kill): 367 mg/kgKHZDAN 27,451,1984
skin/rabbit lethal dose (50 percent kill): 4830 mg/kg85JFAN A343,1983
skin/rat lethal dose (50 percent kill): >5 gm/kgFMCHA2 -,C251,1991
unreported route/mammal (species unspecified) lowest published toxic dose: 100 mg/kgImmunological Including Allergic: Decrease in cellular immune responseHBPTO* 1,777,2001
unreported route/rabbit lethal dose (50 percent kill): 500 mg/kg30ZDA9 -,124,1971
unreported route/rat lethal dose (50 percent kill): 1300 mg/kg30ZDA9 -,124,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/cat lowest published toxic concentration: 5600 µg/m3/4H/9W- intermittentLung, Thorax, or Respiration: Changes in lung weight

Endocrine: Changes in adrenal weight
GISAAA 35(8),31,1970
inhalation/rat lowest published toxic concentration: 5300 µg/m3/4H/21D- intermittentBlood: Changes in other cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GISAAA 35(8),31,1970
inhalation/rat lowest published toxic concentration: 5600 µg/m3/4H/9W- intermittentLung, Thorax, or Respiration: Changes in lung weight

Endocrine: Changes in adrenal weight

Blood: Changes in other cell count (unspecified)
GISAAA 35(8),31,1970
inhalation/rat lowest published toxic concentration: 7 µg/kg/24H/14W- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GISAAA 40(9),17,1975
oral/mammal (species unspecified) lowest published toxic dose: 86913 mg/kg/30D- continuousBehavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** PB288-416
oral/rat lowest published toxic dose: 6600 mg/kg/6W- intermittentBlood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
KHZDAN 27,451,1984
oral/rat lowest published toxic dose: 15015 mg/kg/13W- continuousLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Normocytic anemia
TXAPA9 23,650,1972
oral/rat lowest published toxic dose: 58240 mg/kg/2Y- continuousLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Pigmented or nucleated red blood cells
TXAPA9 23,650,1972

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFEREAC 71,56425,2006
TOXICOLOGY REVIEWFEREAC 72,28881,2007
TOXICOLOGY REVIEWHUTOX* -,551,1996

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,145,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, JUN2003

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Aspergillus-forward mutation; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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