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Propionaldehyde, 3 - (methylthio) -

RTECS #: UE2285000

CAS #: 3268-49-3


UPDATE: August 2006 MW: 104.18 MF: C4H8OS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 3 - (Methylmercapto) propionaldehyde
  2. 3 - (Methylthio) propanal
  3. 3 - (Methylthio) propionaldehyde
  4. 3 - MTP
  5. Methional
  1. Methylmercaptopropionic aldehyde
  2. Propanal, 3 - (methylthio) - (9CI)
  3. beta - (Methylmercapto) propionaldehyde
  4. beta - (Methylthio) propionaldehyde


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
0.1 mL moderate VHTODE 42,77,2000
skin
rabbit
500 L/24 hour severe NTIS** OTS0546239
skin
rabbit
0.5 mL/4 hour moderate VHTODE 42,77,2000


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
micronucleus test inhalation
mouse
37.4 ppm/1 hour/2 day VHTODE 42,77,2000


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 5,400 mg/m3/2 hour N/R GISAAA 49(1),85,1984
inhalation
mouse
lethal concentration (50 percent kill): 5,400 mg/m3/2 hour Brain and Coverings: Other degenerative changes

Liver: Liver function tests impaired
VCVGK* -,372,1984
inhalation
rat
lethal concentration (50 percent kill): 5,820 mg/m3/4 hour N/R GISAAA 49(1),85,1984
inhalation
rat
lethal concentration (50 percent kill): 5,820 mg/m3/4 hour Brain and Coverings: Other degenerative changes

Liver: Liver function tests impaired
VCVGK* -,372,1984
inhalation
rat
lowest published toxic concentration: 246.2 ppm Nutritional and Gross Metabolic: Weight loss or decreased weight gain VHTODE 42,330,2000
oral
mouse
lethal dose (50 percent kill): 1,620 mg/kg N/R GISAAA 49(1),85,1984
oral
mouse
lethal dose (50 percent kill): 1,620 mg/kg Brain and Coverings: Other degenerative changes

Liver: Liver function tests impaired
VCVGK* -,372,1984
oral
rat
lethal dose (50 percent kill): 700 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Gastrointestinal: Alteration in gastric secretion
NTIS** OTS0546239
oral
rat
lethal dose (50 percent kill): 4,400 mg/kg Brain and Coverings: Other degenerative changes

Liver: Liver function tests impaired
VCVGK* -,372,1984
oral
rat
lethal dose (50 percent kill): 1,520 mg/kg Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
VHTODE 42,77,2000
oral
rat
lethal dose (50 percent kill): 1 mL/kg N/R JAPTO* 25,212,2005
skin
rabbit
lowest published lethal dose: 2,500 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea
NTIS** OTS0534366
skin
rabbit
lethal dose (50 percent kill): 747 g/kg/24 hour Eye: Lacrimation

Behavioral: Rigidity (includes catalepsy)

Lung, Thorax, or Respiration: Other changes
VHTODE 42,77,2000
skin
rabbit
lethal dose (50 percent kill): 0.71 mL/kg N/R JAPTO* 25,212,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 246.2 ppm/9 day- continuous Lung, Thorax, or Respiration: Other changes

Liver: Changes in liver weight
VHTODE 42,330,2000
inhalation
rat
lowest published toxic concentration: 96.8 ppm/2 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain VHTODE 42,330,2000
inhalation
rat
lowest published toxic concentration: 23.6 ppm/9 day- continuous Blood: Changes in leukocyte (WBC) count VHTODE 42,330,2000
inhalation
rat
lowest published toxic concentration: 23.6 ppm/9 day- continuous Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation VHTODE 42,330,2000
inhalation
rat
lowest published toxic concentration: 246.2 ppm/9 day- continuous Endocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
VHTODE 42,330,2000
inhalation
rat
lowest published toxic concentration: 246.2 ppm/9 day- continuous Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
VHTODE 42,330,2000
inhalation
rat
lowest published toxic concentration: 96.8 ppm/9 day- continuous Endocrine: Changes in spleen weight

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
VHTODE 42,330,2000
inhalation
rat
lowest published toxic concentration: 127.8 ppm/3 day- intermittent Eye: Lacrimation

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Changes in structure or function of salivary glands
JAPTO* 25,212,2005
inhalation
rat
lowest published toxic concentration: 127.8 ppm/3 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JAPTO* 25,212,2005
inhalation
rat
lowest published toxic concentration: 58.3 ppm/4 day- intermittent Behavioral: Food intake (animal) JAPTO* 25,212,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83834;
Number of Industries 1;
Total Number of Facilities 21;
Number of Occupations 3;
Total Number of Employees Exposed 207


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-

RTECS Compound Description:
   Mutagen
   Primary Irritant

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