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Registry of Toxic Effects of Chemical Substances (RTECS)

Propionaldehyde, 3-(methylthio)-

RTECS #

UE2285000

CAS #

3268-49-3

Updated

August 2006

Molecular Weight

104.18

Molecular Formula

C4H8OS

Synonyms

3-(Methylmercapto)propionaldehyde
3-(Methylthio)propanal
3-(Methylthio)propionaldehyde
3-MTP
beta-(Methylmercapto)propionaldehyde
beta-(Methylthio)propionaldehyde
Methional
Methylmercaptopropionic aldehyde
Propanal, 3-(methylthio)- (9CI)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 0.01 mL moderateVHTODE 42,77,2000
skin /rabbit 500 µL/24H severeNTIS** OTS0546239
skin /rabbit 0.5 mL/4H moderateVHTODE 42,77,2000

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
micronucleus testinhalation/mouse37.4 ppm/1H/2DVHTODE 42,77,2000

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 5400 mg/m3/2HGISAAA 49(1),85,1984
inhalation/mouse lethal concentration (50 percent kill): 5400 mg/m3/2HBrain and Coverings: Other degenerative changes

Liver: Liver function tests impaired
VCVGK* -,372,1984
inhalation/rat lethal concentration (50 percent kill): 5820 mg/m3/4HBrain and Coverings: Other degenerative changes

Liver: Liver function tests impaired
VCVGK* -,372,1984
inhalation/rat lethal concentration (50 percent kill): 5820 mg/m3/4HGISAAA 49(1),85,1984
inhalation/rat lowest published toxic concentration: 246.2 ppmNutritional and Gross Metabolic: Weight loss or decreased weight gainVHTODE 42,330,2000
oral/mouse lethal dose (50 percent kill): 1620 mg/kgGISAAA 49(1),85,1984
oral/mouse lethal dose (50 percent kill): 1620 mg/kgBrain and Coverings: Other degenerative changes

Liver: Liver function tests impaired
VCVGK* -,372,1984
oral/rat lethal dose (50 percent kill): 4400 mg/kgBrain and Coverings: Other degenerative changes

Liver: Liver function tests impaired
VCVGK* -,372,1984
oral/rat lethal dose (50 percent kill): 1520 mg/kgEye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
VHTODE 42,77,2000
oral/rat lethal dose (50 percent kill): 1 mL/kgJAPTO* 25,212,2005
oral/rat lethal dose (50 percent kill): 700 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Gastrointestinal: Alteration in gastric secretion
NTIS** OTS0546239
skin/rabbit lethal dose (50 percent kill): 0.71 mL/kgJAPTO* 25,212,2005
skin/rabbit lethal dose (50 percent kill): 747 µg/kg/24HEye: Lacrimation

Behavioral: Rigidity (includes catalepsy)

Lung, Thorax, or Respiration: Other changes
VHTODE 42,77,2000
skin/rabbit lowest published lethal dose: 2500 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea
NTIS** OTS0534366

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 246.2 ppm/9D- continuousLung, Thorax, or Respiration: Other changes

Liver: Changes in liver weight
VHTODE 42,330,2000
inhalation/rat lowest published toxic concentration: 96.8 ppm/2D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainVHTODE 42,330,2000
inhalation/rat lowest published toxic concentration: 23.6 ppm/9D- continuousBlood: Changes in leukocyte (WBC) countVHTODE 42,330,2000
inhalation/rat lowest published toxic concentration: 23.6 ppm/9D- continuousBiochemical: Metabolism (intermediary): Plasma proteins not involving coagulationVHTODE 42,330,2000
inhalation/rat lowest published toxic concentration: 246.2 ppm/9D- continuousEndocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
VHTODE 42,330,2000
inhalation/rat lowest published toxic concentration: 246.2 ppm/9D- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
VHTODE 42,330,2000
inhalation/rat lowest published toxic concentration: 96.8 ppm/9D- continuousEndocrine: Changes in spleen weight

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
VHTODE 42,330,2000
inhalation/rat lowest published toxic concentration: 127.8 ppm/3D- intermittentEye: Lacrimation

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Changes in structure or function of salivary glands
JAPTO* 25,212,2005
inhalation/rat lowest published toxic concentration: 127.8 ppm/3D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJAPTO* 25,212,2005
inhalation/rat lowest published toxic concentration: 58.3 ppm/4D- intermittentBehavioral: Food intake (animal)JAPTO* 25,212,2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Hazard Survey 1974Hazard Code 83834; Number of Industries 1; Total Number of Facilities 21; Number of Occupations 3; Total Number of Employees Exposed 207

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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