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Registry of Toxic Effects of Chemical Substances (RTECS)

Propionaldehyde, 2-methyl-2-(methylthio)-, O-(methylcarbamoyl)oxime

RTECS #

UE2275000

CAS #

116-06-3

Updated

July 2012

Molecular Weight

190.29

Molecular Formula

C7H14N2O2S

Synonyms

2-Methyl-2-(methylthio)propanal, O-((methylamino)carbonyl)oxime
2-Methyl-2-(methylthio)propionaldehyde O-(methylcarbamoyl)oxime
2-Methyl-2-(methylthio)propionaldehyde O-methyl-carbamoyloxime
2-Methyl-2-methylthio-propionaldehyd-O-(N-methyl-carbamoyl)-oxim (German)
2-Metil-2-tiometil-propionaldeid-O-(N-metil-carbamoil)-ossima (Italian)
AI3-27093
Aldicarb
Aldicarbe (French)
Carbamic acid, methyl-, O-((2-methyl-2-(methylthio)propylidene)amino) deriv.
ENT 27,093
NCI-C08640
OMS-771
Propanal, 2-methyl-2-(methylthio)-, O-((methylamino)carbonyl)oxime
RCRA waste number P070
Temik
Temik 10 G
TEMIK G
Temik G10
UC-21149
Union carbide UC-21149

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human350 mg/LMUREAV 191,99,1987
Cytogenetic Analysisovary/hamster2.5 mg/L/2HFCTOD7 45,928,2007
DNA repair/Salmonella typhimurium1 mg/discJPFCD2 21,319,1986
morphological transformembryo/rat117 µg/plateJJATDK 1,190,1981
mutation in mammalian somatic cellslymphocyte/mouse839 mg/LEMMUEG 12(Suppl 13),37,1988
mutation in mammalian somatic cellslymphocyte/human2 gm/LMUREAV 196,61,1988
mutation in microorganismslymphocyte/mouse500 mg/L (+enzymatic activation step)EMMUEG 12(Suppl 13),103,1988
sister chromatid exchangelymphocyte/human10 mg/LMUREAV 138,175,1984
specific locus testoral/mouse21024 µmol/LMUREAV 608,29,2006

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/pigeon 7 mg/kg (7D prior to copulation)Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Other effects to embryo or fetus

Reproductive: Effects on newborn: Other neonatal measures or effects
TOXID9 -,14,2008

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 200 mg/m3/5H85JCAE -,999,1986
intraperitoneal/mammal (species unspecified) lowest published toxic dose: 1000 ppbBlood: Changes in cell count (unspecified)

Immunological Including Allergic: Decrease in cellular immune response
HBPTO* 1,776,2001
intraperitoneal/rat lethal dose (50 percent kill): 0.5 mg/kgPeripheral Nerve and Sensation: Fasciculations

Lung, Thorax, or Respiration: Dyspnea
TXCYAC 242,1,2007
intraperitoneal/rat lethal dose (50 percent kill): 280 µg/kgTSCAT* FYI-OTS-0885-0443
intravenous/rat lethal dose (50 percent kill): 470 µg/kgTSCAT* FYI-OTS-0885-0443
oral/chicken lethal dose (50 percent kill): 8 mg/kg85GYAV -,62,1971
oral/domestic animal lowest published lethal dose: 5 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Eye: Lacrimation
BVJOA9 146,358,1990
oral/duck lethal dose (50 percent kill): 3400 µg/kgTXAPA9 47,451,1979
oral/guinea pig lethal dose (50 percent kill): 1 mg/kgHBPTO* 2,1094,2001
oral/human lowest published toxic dose: 0.1 mg/kgHBPTO* 2,1097,2001
oral/human lowest published toxic dose: 0.1 mg/kgAutonomic Nervous System: Other (direct) parasympathomimeticHBPTO* 2,1097,2001
oral/human lowest published toxic dose: 0.01 mg/kgBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 1,55,2001
oral/man lowest published toxic dose: 0.075 mg/kgSkin and Appendages: Other: SweatingTOXID9 1,56,2001
oral/man lowest published toxic dose: 0.025 mg/kgBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 1,56,2001
oral/mouse lethal dose (50 percent kill): 300 µg/kgJAFCAU 18,793,1970
oral/pigeon lethal dose (50 percent kill): 3160 µg/kgASTTA8 (680),157,1979
oral/pigeon lowest published toxic dose: 0.25 mg/kgBehavioral: Alteration of classical conditioningTOXID9 -,270,2009
oral/pigeon lowest published toxic dose: 0.1 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTOXID9 -,270,2009
oral/quail lethal dose (50 percent kill): 2 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
EESADV 8,551,1984
oral/rabbit lethal dose (50 percent kill): 1.3 mg/kgHBPTO* 2,1094,2001
oral/rat lowest published toxic dose: 0.05 mg/kgBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 1,55,2001
oral/rat lowest published toxic dose: 1 gm/kgLiver: Other changesTXAPA9 197,256,2004
oral/rat lethal dose (50 percent kill): 0.46 mg/kgHBPTO* 2,1094,2001
oral/rat lowest published toxic dose: 0.5 mg/kg/45MBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 2,1111,2001
oral/wild bird lethal dose (50 percent kill): 750 µg/kgASTTA8 (680),157,1979
oral/woman lowest published toxic dose: 28 mg/kg/10D- intermittentCardiac: Pulse rate decreased with fall in BP

Gastrointestinal: Changes in structure or function of exocrine pancreas

Nutritional and Gross Metabolic: Body temperature decrease
ICMED9 20,49,1994
skin/guinea pig lethal dose (50 percent kill): 2400 mg/kg85DPAN -,-,1971/1976
skin/rabbit lethal dose (50 percent kill): 5 mg/kgUSXXAM #6193990
skin/rat lowest published toxic dose: 5 mg/kgBrain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 1,56,2001
skin/rat lethal dose (50 percent kill): 2500 µg/kgTXAPA9 14,515,1969
subcutaneous/mouse lethal dose (50 percent kill): 250 µg/kgTOIZAG 17,60,1970
subcutaneous/mouse lowest published lethal dose: 0.53 mg/kgARTODN 76,173,2002
subcutaneous/rat lethal dose (50 percent kill): 666 µg/kgTXAPA9 25,569,1973
unreported route/rat lethal dose (50 percent kill): 930 µg/kg30ZDA9 -,197,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 8400 µg/kg/21D- intermittentEye: Lacrimation

Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands
DDREDK 24,343,1991
oral/Dog lowest published toxic dose: 20.02 mg/kg/52W- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 2,1113,2001
oral/Dog lowest published toxic dose: 87.36 mg/kg/52W- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 2,1113,2001
oral/Dog lowest published toxic dose: 2.345 mg/kg/5W- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 2,1110,2001
oral/domestic animal lowest published toxic dose: 4 mg/kg/40D- intermittentLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
BVJOA9 146,358,1990
oral/mouse lowest published toxic dose: 4500 µg/kg/15D- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
BECTA6 63,575,1999
oral/rat lowest published toxic dose: 46.5 mg/kg/93D- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 2,1110,2001
oral/rat lowest published toxic dose: 1440 mg/kg/120D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterasePHTOEH 89,249,2001
oral/rat lowest published toxic dose: 14.4 gm/kg/120D- intermittentBehavioral: Change in motor activity (specific assay)

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
PHTOEH 89,249,2001
oral/rat lowest published toxic dose: 144 gm/kg/120D- intermittentBehavioral: Change in psychophysiological tests

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
PHTOEH 89,249,2001
oral/rat lowest published toxic dose: 365 mg/kg/2Y- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1113,2001
oral/rat lowest published toxic dose: 1.095 gm/kg/2Y- continuousEye: Other eye effectsHBPTO* 2,1113,2001
oral/rat lowest published toxic dose: 1.095 gm/kg/2Y- continuousEye: Other eye effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1113,2001
oral/rat lowest published toxic dose: 1.4 mg/kg/4W- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 2,1112,2001
oral/rat lowest published toxic dose: 5.6 mg/kg/4W- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 2,1112,2001
oral/rat lowest published toxic dose: 437 mg/kg/2Y- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldRCTOE4 104,21,1988

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 53,93,1991
International Agency for Research on Cancer (IARC)Cancer Review:Human No Available DataIMEMDT 53,93,1991
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 53,93,1991
TOXICOLOGY REVIEWMUREAV 557,109,2004
TOXICOLOGY REVIEWTOLED5 134,3,2002
TOXICOLOGY REVIEWMUREAV 562,77,2004
TOXICOLOGY REVIEWFSINDR 146S,S79,2004
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWAEMED3 45,609,2005
TOXICOLOGY REVIEWENTOX* -,64,2005
TOXICOLOGY REVIEWENTOX* -,588,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWFEREAC 73,31788,2008
TOXICOLOGY REVIEWMUREAV 672,10,2009
TOXICOLOGY REVIEWMUREAV 672,17,2009
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWFEREAC 73,54954,2008
TOXICOLOGY REVIEWHETOEA 26,321,2007
TOXICOLOGY REVIEWTOLED5 190,107,2009
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,82,1998

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,ratNCITR* NCI-TR-136,1979
On EPA IRIS database
OSHA ANALYTICAL METHOD #74
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