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Propionaldehyde, 2 - methyl - 2 - (methylthio) - , O - (methylcarbamoyl) oxime

RTECS #: UE2275000

CAS #: 116-06-3


UPDATE: May 2009 MW: 190.29 MF: C7H14N2O2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Methyl - 2 - (methylthio) propanal, O - ( (methylamino) carbonyl) oxime
  2. 2 - Methyl - 2 - (methylthio) propionaldehyde O - (methylcarbamoyl) oxime
  3. 2 - Methyl - 2 - (methylthio) propionaldehyde O - methyl - carbamoyloxime
  4. 2 - Methyl - 2 - methylthio - propionaldehyd - O - (N - methyl - carbamoyl) - oxim (German)
  5. 2 - Metil - 2 - tiometil - propionaldeid - O - (N - metil - carbamoil) - ossima (Italian)
  6. AI3 - 27093
  7. Aldicarb
  8. Aldicarbe (French)
  9. Carbamic acid, methyl - , O - ( (2 - methyl - 2 - (methylthio) propylidene) amino) deriv.
  10. ENT 27,093
  1. NCI - C08640
  2. OMS - 771
  3. Propanal, 2 - methyl - 2 - (methylthio) - , O - ( (methylamino) carbonyl) oxime
  4. RCRA waste number P070
  5. TEMIK G
  6. Temik
  7. Temik 10 G
  8. Temik G10
  9. UC - 21149
  10. Union carbide UC - 21149


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 2.5 mg/L/2 hour FCTOD7 45,928,2007
cytogenetic analysis human lymphocyte 350 mg/L MUREAV 191,99,1987
DNA repair Salmonella typhimurium 1 mg/disc JPFCD2 21,319,1986
mutation in microorganisms mouse lymphocyte 500 mg/L (+enzymatic activation step) EMMUEG 12(Suppl 13),103,1988
mutation in mammalian somatic cells human lymphocyte 2 gm/L MUREAV 196,61,1988
mutation in mammalian somatic cells mouse lymphocyte 839 mg/L EMMUEG 12(Suppl 13),37,1988
morphological transform rat embryo 117 g/plate JJATDK 1,190,1981
sister chromatid exchange human lymphocyte 10 mg/L MUREAV 138,175,1984
specific locus test oral
mouse
21,024 mol/L MUREAV 608,29,2006


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
pigeon
lowest published toxic dose: 7 mg/kg (7 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Other effects to embryo or fetus

Reproductive: Effects on newborn: Other neonatal measures or effects
TOXID9 -,14,2008


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 200 mg/m3/5 hour N/R 85JCAE -,999,1986
intraperitoneal
mammal (species unspecified)
lowest published toxic dose: 1,000 ppb Blood: Changes in cell count (unspecified)

Immunological Including Allergic: Decrease in cellular immune response
HBPTO* 1,776,2001
intraperitoneal
rat
lethal dose (50 percent kill): 280 g/kg N/R TSCAT* FYI-OTS-0885-0443
intraperitoneal
rat
lethal dose (50 percent kill): 0.5 mg/kg Peripheral Nerve and Sensation: Fasciculations

Lung, Thorax, or Respiration: Dyspnea
TXCYAC 242,1,2007
intravenous
rat
lethal dose (50 percent kill): 470 g/kg N/R TSCAT* FYI-OTS-0885-0443
oral
wild bird
lethal dose (50 percent kill): 750 g/kg N/R ASTTA8 (680),157,1979
oral
chicken
lethal dose (50 percent kill): 8 mg/kg N/R 85GYAV -,62,1971
oral
duck
lethal dose (50 percent kill): 3,400 g/kg N/R TXAPA9 47,451,1979
oral
domestic animal
lowest published lethal dose: 5 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Eye: Lacrimation
BVJOA9 146,358,1990
oral
guinea pig
lethal dose (50 percent kill): 1 mg/kg N/R HBPTO* 2,1094,2001
oral
human
lowest published toxic dose: 0.1 mg/kg N/R HBPTO* 2,1097,2001
oral
human
lowest published toxic dose: 0.1 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic HBPTO* 2,1097,2001
oral
human
lowest published toxic dose: 0.1 mg/kg Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 1,55,2001
oral
man
lowest published toxic dose: 0.75 mg/kg Skin and Appendages: Other: Sweating TOXID9 1,56,2001
oral
man
lowest published toxic dose: 0.25 mg/kg Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 1,56,2001
oral
mouse
lethal dose (50 percent kill): 300 g/kg N/R JAFCAU 18,793,1970
oral
pigeon
lethal dose (50 percent kill): 3,160 g/kg N/R ASTTA8 (680),157,1979
oral
quail
lethal dose (50 percent kill): 2 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
EESADV 8,551,1984
oral
rat
lethal dose (50 percent kill): 0.46 mg/kg N/R HBPTO* 2,1094,2001
oral
rat
lowest published toxic dose: 0.5 mg/kg/45 minute Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 2,1111,2001
oral
rat
lowest published toxic dose: 1 gm/kg Liver: Other changes TXAPA9 197,256,2004
oral
rat
lowest published toxic dose: 0.5 mg/kg Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 1,55,2001
oral
rabbit
lethal dose (50 percent kill): 1.3 mg/kg N/R HBPTO* 2,1094,2001
oral
woman
lowest published toxic dose: 28 mg/kg/10 day- intermittent Cardiac: Pulse rate decreased with fall in BP

Gastrointestinal: Changes in structure or function of exocrine pancreas

Nutritional and Gross Metabolic: Body temperature decrease
ICMED9 20,49,1994
subcutaneous
mouse
lethal dose (50 percent kill): 250 g/kg N/R TOIZAG 17,60,1970
subcutaneous
mouse
lowest published lethal dose: 0.53 mg/kg N/R ARTODN 76,173,2002
subcutaneous
rat
lethal dose (50 percent kill): 666 g/kg N/R TXAPA9 25,569,1973
skin
guinea pig
lethal dose (50 percent kill): 2,400 mg/kg N/R 85DPAN -,-,1971/1976
skin
rat
lethal dose (50 percent kill): 2,500 g/kg N/R TXAPA9 14,515,1969
skin
rat
lowest published toxic dose: 5 mg/kg Brain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 1,56,2001
skin
rabbit
lethal dose (50 percent kill): 5 mg/kg N/R USXXAM #6193990
unreported route
rat
lethal dose (50 percent kill): 930 g/kg N/R 30ZDA9 -,197,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 8,400 g/kg/21 day- intermittent Eye: Lacrimation

Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands
DDREDK 24,343,1991
oral
dog
lowest published toxic dose: 20.02 mg/kg/52 week- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 2,1113,2001
oral
dog
lowest published toxic dose: 87.36 mg/kg/52 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 2,1113,2001
oral
dog
lowest published toxic dose: 2.345 mg/kg/5 week- continuous Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 2,1110,2001
oral
domestic animal
lowest published toxic dose: 4 mg/kg/40 day- intermittent Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
BVJOA9 146,358,1990
oral
mouse
lowest published toxic dose: 4,500 g/kg/15 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
BECTA6 63,575,1999
oral
rat
lowest published toxic dose: 437 mg/kg/2 year- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field RCTOE4 104,21,1988
oral
rat
lowest published toxic dose: 1,440 mg/kg/120 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase PHTOEH 89,249,2001
oral
rat
lowest published toxic dose: 14.4 gm/kg/120 day- intermittent Behavioral: Change in motor activity (specific assay)

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
PHTOEH 89,249,2001
oral
rat
lowest published toxic dose: 144 gm/kg/120 day- intermittent Behavioral: Change in psychophysiological tests

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
PHTOEH 89,249,2001
oral
rat
lowest published toxic dose: 365 mg/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1113,2001
oral
rat
lowest published toxic dose: 1.095 gm/kg/2 year- continuous Eye: Other eye effects HBPTO* 2,1113,2001
oral
rat
lowest published toxic dose: 1.095 gm/kg/2 year- continuous Eye: Other eye effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1113,2001
oral
rat
lowest published toxic dose: 46.5 mg/kg/93 day- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 2,1110,2001
oral
rat
lowest published toxic dose: 1.4 mg/kg/4 week- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 2,1112,2001
oral
rat
lowest published toxic dose: 5.6 mg/kg/4 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 2,1112,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 53,93,1991
International Agency for Research on Cancer (IARC) Cancer Review Human No Available Data IMEMDT 53,93,1991
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 53,93,1991
TOXICOLOGY REVIEW
MUREAV 557,109,2004
TOXICOLOGY REVIEW
TOLED5 134,3,2002
TOXICOLOGY REVIEW
MUREAV 562,77,2004
TOXICOLOGY REVIEW
FSINDR 146S,S79,2004
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
AEMED3 45,609,2005
TOXICOLOGY REVIEW
ENTOX* -,64,2005
TOXICOLOGY REVIEW
ENTOX* -,588,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
JTEHD6 7,1,2004
TOXICOLOGY REVIEW
FEREAC 73,31788,2008
TOXICOLOGY REVIEW
FEREAC 73,31788,2008
TOXICOLOGY REVIEW
MUREAV 672,10,2009
TOXICOLOGY REVIEW
MUREAV 672,17,2009
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,82,1998
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an agricultural chemical and pesticide
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-136,1979
OSHA ANALYTICAL METHOD #74


REFERENCES:

CODEN
REFERENCE

30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
85GYAV "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038)
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BVJOA9 British Veterinary Journal. (Bailliere Tindall, 33 The Avenue, Eastbourne BN21 3UN, UK) V.105- 1949-
DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981-
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FSINDR Forensic Science International. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.12- 1978-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HTOPA*
ICMED9 Intensive Care Medicine. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1977-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.B11- 1976-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RCTOE4 Reviews of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.98- 1987-
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)

Used as an agricultural chemical and pesticide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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